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Human Monoclonal KAT5 Primary Antibody for IHC, ELISA - ABIN1724672
Jin, Cai, Li, Conaway, Workman, Conaway, Kusch: In and out: histone variant exchange in chromatin. in Trends in biochemical sciences 2005
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Human Polyclonal KAT5 Primary Antibody for IHC (p), SimWes - ABIN4359854
Krukenberg, Jiang, Steen, Mitchison: Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines. in Cell reports 2014
Human Polyclonal KAT5 Primary Antibody for ICC, IF - ABIN4359851
Laurberg, Brems-Eskildsen, Nordentoft, Fristrup, Schepeler, Ulhøi, Agerbaek, Hartmann, Bertz, Wittlinger, Fietkau, Rödel, Borre, Jensen, Orntoft, Dyrskjøt: Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic recombination 11 homolog) predict treatment-specific outcome of localised invasive bladder cancer. in BJU international 2013
Human Polyclonal KAT5 Primary Antibody for WB - ABIN387933
Cai, Jin, Florens, Swanson, Kusch, Li, Workman, Washburn, Conaway, Conaway: The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. in The Journal of biological chemistry 2005
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most HIF1A (show HIF1A Antibodies) targets require either TIP60, the CDK8 (show CDK8 Antibodies)-Mediator complex, or both as coactivators for full expression in hypoxia.
Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder.
compromising Tip60 histone acetyltransferase (show HAT Antibodies) activity in the CySC (show CST3 Antibodies) lineage recapitulates loss-of-function phenotypes of E(Pc), suggesting that Tip60 and E(Pc) act together, consistent with published biochemical data.
Heat Shock Factor recruits the dTip60 complex to the hsp70 loci in cells treated with salicylate, which triggers chromatin remodeling at these loci without transcription activation.
Excess Tip60 exerts a neuroprotective role in axonal transport and functional locomotion defects in an animal model of Alzheimer's disease.
a novel mechanism for Tip60 mediated sleep-wake regulation via control of axonal growth and PDF levels within the small ventrolateral neurons-encompassing neural network
a functional interaction between Tip60 and APP (show APP Antibodies) in mediating nervous system development and apoptotic neuronal cell death
The role of Tip60 HAT (show HAT Antibodies) activity in transcriptional control during multicellular development in vivo, was investigated.
Ubiquitous dTip60 knock-down in flies was lethal, whereas knock-down in the wing imaginal disk led to developmental defects.
demonstrated that the dTip60 chromatin-remodeling complex acetylates nucleosomal phospho-H2Av (show H2AFV Antibodies) and exchanges it with an unmodified H2Av (show H2AFV Antibodies); both the histone acetyltransferase (show HAT Antibodies) dTip60 and the atpase (show DNAH8 Antibodies) Domino/p400 (show EP400 Antibodies) catalyze the exchange of phospho-H2Av (show H2AFV Antibodies)
Irreversible inhibition of USP7 (show USP7 Antibodies) results in durable downstream biological responses in cells, including down-regulation of Tip60 and consequent impairment of Treg suppressive function
NOTCH1 (show NOTCH1 Antibodies) inhibits activation of ATM (show ATM Antibodies) by impairing the formation of an ATM (show ATM Antibodies)-FOXO3a (show FOXO3 Antibodies)-KAT5 complex.
Collectively, the data establish a hitherto unknown liaison among MDR1 (show TBC1D9 Antibodies), BMI1 (show BMI1 Antibodies) and TIP60 and provide mechanistic insights into cisplatin-induced MDR1 (show TBC1D9 Antibodies) expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.
TIP60-mediated growth suppression of HPV-induced cervical cancer is mediated in part due to TERT (show TERT Antibodies) repression through Sp1 (show PSG1 Antibodies) acetylation. In summary, our study has identified a novel substrate for TIP60 catalytic activity and a unique repressive mechanism acting at the TERT (show TERT Antibodies) promoter in virus-induced malignancies.
These findings reveal that Endoplasmic reticulum stress engages the GSK3beta (show GSK3b Antibodies)-TIP60-ULK1 (show ULK1 Antibodies) pathway to increase autophagy.
Methylation of RUVBL1 (show RUVBL1 Antibodies) by the arginine methyltransferase PRMT5 (show PRMT5 Antibodies) is required for homologous recombination-mediated double-strand break repair by promoting TIP60-mediated histone H4K16 acetylation.
TIP60 complex regulates bivalent chromatin recognition/modification by 53BP1 (show TP53BP1 Antibodies) through direct H4K20me binding and H2AK15 acetylation.
Studies suggest that lysine (K) acetyltransferase inhibitors (KATi (show CCBL1 Antibodies)) are important for providing personalized therapies.
Thus Tip60 interacts with RNR (show NR2E3 Antibodies) and NME3 (show NME3 Antibodies) to provide site-specific synthesis of dNTP for facilitating DNA repair in serum-deprived cells which contain low levels of dNTPs.
Tip60 controls homologous recombination (HR)-directed DNA repair, and that Tip60 levels correlate inversely with a gene expression signature associated with defective HR-directed DNA repair.
Results report that EPC1 (show EPC1 Antibodies) and TIP60 are co-expressed in male germ cells. Genetic ablation of either Epc1 (show EPC1 Antibodies) or Tip60 disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant spermatid development.
these results identify a new compaction pathway of mammalian pericentric heterochromatin relying on Tip60 that might be dependent on BRD2 (show BRD2 Antibodies) recruitment by H4K12 acetylation.
The expression of putative SOX4 target genes during myoblast differentiation is specifically regulated by the molecular switching of the co-activator KAT5 and the co-repressor HDAC1 on SOX4 transcriptional activation.
TIP60 K327 acetylation allows TIP60 to switch binding partners. conditional knockout in Treg cells results in autoimmune disease.
Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo.
Tip60 hyperacetylates histone H4 in Ras-transformed cells.Tip60 coordinates histone acetylation at both local and global levels to facilitate Ras-induced transformation.
RGS6 (show RGS6 Antibodies) suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 (show DNMT1 Antibodies) degradation and promoting apoptosis
Early adipogenesis is regulated through USP7 (show USP7 Antibodies)-mediated deubiquitination of the histone acetyltransferase TIP60.
SLX2 interacts with synaptonemal complex central element protein 2 (SYCE2 (show SYCE2 Antibodies)) and histone acetyltransferase TIP60.
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.
K(lysine) acetyltransferase 5
, Tat-interactive protein
, histone acetyltransferase Tip60
, HIV-1 tat interactive protein
, 60 kDa Tat-interactive protein
, HIV-1 Tat interactive protein, 60kDa
, K-acetyltransferase 5
, Tat interacting protein, 60kDa
, cPLA(2)-interacting protein
, cPLA2 interacting protein
, histone acetyltransferase HTATIP
, histone acetyltransferase KAT5
, HIV-1 tat interactive protein 1, 60 kDa homolog
, HIV-1 tat interactive protein 1, homolog
, Tat-interactive protein-60
, lysine acetyltransferase 5
, HIV-1 Tat interacting protein, 60kDa
, HIV-1 Tat interactive protein 60 kD
, HIV-1 Tat interactive protein, 60 kD
, HIV-1 tat interactive protein, homolog
, Histone acetyltransferase HTATIP