Protein Summary

The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997

Alternative names and synonyms associated with NCOA2

• nuclear receptor coactivator 2 (NCOA2) antibody
• nuclear receptor coactivator 2 (Ncoa2) antibody
• nuclear receptor coactivator 2 (ncoa2) antibody
• nuclear receptor coactivator 2 (LOC100089041) antibody
• nuclear receptor coactivator 2 S homeolog (ncoa2.S) antibody

• 9530095N19 antibody
• bhlhe75 antibody
• D1Ertd433e antibody
• GRIP-1 antibody
• grip1 antibody
• Show all synonym aliases
• kat13c antibody
• NCoA-2 antibody
• NCOA2 antibody
• ncoa2-A antibody
• SRC-2 antibody
• src2 antibody
• TIF-2 antibody
• Tif2 antibody
• wu:fc41a10 antibody
• wu:fe26a11 antibody
• XTIF2 antibody

Protein level used designations for NCOA2

class E basic helix-loop-helix protein 75 , glucocorticoid receptor-interacting protein-1 , hTIF2 , transcriptional intermediary factor 2 , NCoA-2 , TIF2/GRIP-1 , glucocorticoid receptor interacting protein 1 , glucocorticoid receptor-interacting protein 1 , grip1 , src2 , steroid receptor coactivator 2 , nuclear receptor coactivator 2 , transcriptional intermediary factor-2 , Transcriptional intermediary factor 2 , nuclear receptor coactivator 2-like