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among the 10 SNPs negatively associated with Nonalcoholic Fatty Liver Disease, the four-locus model (rs13431696 and rs3856806 in PPARgamma, and rs5182, rs1492100 in ATGR1) and the five-locus model (rs9817428, rs1175543, rs13433696, and rs2920502 in PPARgamma, and rs1492100 in ATGR1) were closely related with Nonalcoholic Fatty Liver Disease susceptibility (p = 0.019 and p = 0.048, respectively).
presence in the genotype of patients with 1-2degree arterial hypertension of AGTR1 1166capital ES, Cyrillic allele may be considered a risk factor of early development of chronic kidney disease
These findings imply that overexpression of AT1R on the mesangial cells of IgAN patients is associated with mesangial cell proliferation, glomerular segmental sclerosis, and crescent formation.
autoantibodies against angiotensin II receptor type 1 may play a role in the pathophysiology of preeclampsia.
We conclude that PM2.5 exposure induces MAPK/AP-1 cascade activation, which contributes to AT1R upregulation and vascular endothelial dysfunction.
In a Chinese population, the CC genotype individuals with rs5182 in ATGR1 exhibited an increased hypertriglyceridemia risk.
The H19-let-7b-AT1R axis contributed to the pathogenesis of PAH by stimulating pulmonary arterial smooth muscle cells proliferation.The overexpression of H19 and AT1R could facilitate PASMCs proliferation in vitro.
AT1-agonistic autoantibody induced podocyte damage in a dose-dependent manner.
Intracrine action of angiotensin II in mesangial cells: subcellular distribution of angiotensin II receptor subtypes AT1 and AT2.
Meta-analysis suggests that AGTR1 A1166C polymorphism may increase the susceptibility to diabetic nephropathy.
Results may indicate that the choice of diet can undermine the potential genetic risk of the AT1R 1166A>C polymorphism for MetS, and persons who are variant carriers may spontaneously choose the Mediterranean diet.
The research reveals that among patients with essential hypertension treated with hypotensive drugs there are certain relationships between the rs5182 and rs5186 polymorphisms of the AGTR1 gene, as well as between the rs1799998 polymorphism of the CYP11B2 gene and the volume of the carotid bodies.
The protective effects of short-term hypoxia (STH) are associated with the upregulation of MasR to inhibit AT1 R signaling. STH could be a potential therapeutic strategy for cardiac diseases in hypertensive patients.
A high level of ART1 antibodies was a risk factor for allograft function in kidney transplant recipients.
we found an interaction between ACE2 and AGTR1 in structuralatrial fibrillation patients in a Chinese Han population
AGTR1 DNA hypomethylation is a risk factor for the development of hypertension. Furthermore, there is a correlation between smoking, diet, and AGTR1 DNA methylation levels.
Chinese Han persons with C allele of rs9817428 in PPARG gene were related to the increased risk of hypertension.
Results showed no association between genotypes and preeclampsia for polymorphisms rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2 in women with preeclampsia
Association of AGTR1 single nucleotide polymorphism rs275645 and pre-eclampsia in Chinese population.
although the present study did not find any association between AGTR1 A1166C polymorphism and the risk of systemic lupus erythematosus, the presence of this polymorphism was associated with higher levels of malondialdehyde and higher concentration of neopterin
Study demonstrates a modulatory role of Angiotensin II (Ang II)-Ang II type 1 receptor (AT1-R) in methamphetamine (METH)-induced behavioral effect. The expression of AT1-R is specifically upregulated in the striatum of METH-treated mice. Pharmacological antagonism or genetic deletion of AT1-R attenuates METH-induced behavioral sensitization.
Physiological At1ar signaling in the intimal and medial layers is associated with distinct regulatory processes of aorta homeostasis and function; improper At1ar activity in the vascular endothelium is a significant determinant of thoracic aortic aneurysm development in Marfan syndrome mice.
these data support the expression of AT1A in AVP-producing cells of the supraoptic nucleus but not the paraventricular nucleus
Results provide support of a direct role of BM-derived cells AT1R in Ang II-induced atherosclerosis burden and plaque vulnerability. AT1R activation promotes hepatic mRNA expression of cholesterol-metabolism-related genes and vascular mRNA expression of pro-inflammatory cytokines.
High AT1 receptor expression is associated with myocardial infarction.
GPCR-arrestin complex initiates non-desensitized signalling at the plasma membrane by coupling with ion channels.
the expression of AT2 receptors was significantly increased compared to that of AT1 receptors upon ischemic induction.
Transforming growth factor-beta1 induces cerebrovascular dysfunction and astrogliosis through angiotensin II type 1 receptor-mediated signaling pathways
High AT1R expression is associated with acute lung injury.
QLQX may improve diabetic cardiac function by regulating AGTR1/ TRPV1-mediated autophagy in STZ-induced diabetic mice.
Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms.
AT1R in antigen-specific CD8(+) T cells regulates expansion, differentiation, and function during effector and memory phases of the response against Plasmodium, which could apply to different infectious agents.
Homocysteine displaces angiotensin II, exaggerating injury in abdominal aortic aneurysm.
Nrf2-mediated stimulation of intrarenal Renin-angiotensin system gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes.
This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney.
The formation of liver metastasis, in a mouse model of colorectal cancer, correlated with collagen deposition in the metastatic area, which was dependent on AT1a signaling.
Perivascular Adipose Tissue Angiotensin II Type 1a Receptor Promotes Vascular Inflammation and Aneurysm formation in apolipoprotein E-deficient (ApoE(-/-)) mice.
Mice lacking the AT1A receptor specifically in LEPR-expressing cells failed to show an increase in resting metabolic rate in response to a high-fat diet and deoxycorticosterone acetate-salt (DOCA-salt) treatments, but blood pressure control remained intact.
In wild-type, total (tNCC) and phosphorylated (pNCC) NCC protein expressions were 1.8- and 4.6-fold higher in females compared with males, consistent with the larger response to HCTZ. In AT1a receptor knockout mice, tNCC and pNCC increased significantly in males to levels not different from those in females.
This study showed that activation of the AT1a receptor may contribute to maintenance of the glomerular structure against hypertensive renal damage.
These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II receptor activation is transduced to depolarization-dependent Ca(2+) entry and aldosterone secretion.
Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.
transcripts for the ANGII receptor type 1 (ATR1) were detected in lungs of Xenopus laevis
Ang II increase HTFs proliferation, migration, and phenotype transition, suggesting that Ang II may play a role in wound healing after trabeculectomy.
Renal AT1R expression was increased by approximately 67% and AT2R expression was decreased by approximately 87% in rabbits with heart failure; however, kidneys from denervated rabbits with heart failure showed a near normalization in the expression of these receptors.
Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia-mediated downregulation of Smad7.
Following inflammation in the femoral artery angiotensin AT1 receptors are activated along with thromboxane receptors.
Corneal cells express ACE, AT(1) and AT(2)receptors. ACE inhibitor enalapril decreased corneal angiogenesis in VEGF-induced corneal neovascularization. ACE inhibitors may be novel therapy to treat corneal angiogenesis.
Ascorbic acid decreases the binding affinity of the AT(1) receptor.
investigated whether oxidant stress plays a role in Ang II-induced AT1R upregulation and its relationship to the transcription factor activator protein 1 (AP1) in CHF rabbits and in the CATHa neuronal cell line
Results implicate AT(1) receptor and tyrosine kinases in the hyposmotic modulation of atrial I (Ks) and suggest acute antiarrhythmic properties of AT(1) antagonists in the settings of stretch-related atrial tachyarrhythmias.
Luminal ANG II is internalized as a complex with AT1R/AT2R heterodimers to target endoplasmic reticulum in LLC-PK1 cells, where it might trigger intracellular calcium responses.
These studies provide insight into kidney biology as the first in vivo/in vitro experimental evidence about AT(1)R regulation in response to reduced perfusion of the kidney.
AT1 and AT2 receptors heterodimerize and are involved in the angiotensin II effect on SERCA in proximal kidney tubules.
A critical role for lipid raft microdomains in AGTR1-mediated signal transduction in neonatal glomerular mesengial cells.
AT1 receptors are positively coupled to the proliferative response of vascular smooth muscle cells to angiotensin II.
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed\; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
type-1 angiotensin II receptor
, type-1B angiotensin II receptor
, angiotensin II type-1A receptor
, angiotensin receptor 1
, angiotensin receptor 1a
, type-1A angiotensin II receptor
, angiotensin II receptor 1
, angiotensin II type-1 receptor
, angiotensin 2 receptor, type 1, gene 2
, angiotensin 2 receptor, type 1-B
, angiotensin II receptor, type 1
, angiotensin II receptor, type 1-B
, angiotensin II type-1 receptor 2
, angiotensin type 1 receptor
, type-1 angiotensin II receptor B
, type-1-like angiotensin II receptor 2
, angiotensin II type 1 receptor
, AT1 ANG II receptor
, AT1 angiotensin II receptor
, Type-1 angiotensin II receptor
, angiotensin receptor
, Angiotensin II type-1 receptor
, Angiotensin 2 receptor, type 1-A
, Angiotensin II receptor, type 1-A
, Type-1-like angiotensin II receptor 1
, angiotensin 2 receptor, type 1 L homeolog
, angiotensin 2 receptor, type 1-A
, angiotensin II receptor, type 1-A
, angiotensin II type-1 receptor 1
, angiotensin type 1
, type-1 angiotensin II receptor A