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The DEGs (show DEGS1 Proteins), such as AGTR1, CYP3A4 (show CYP3A4 Proteins) and CYP4A11 may play critical roles in the development of HTN likely via the regulation by hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-26b-5p and taking part in some pathways.
Low shear stress induces the generation of endothelial reactive oxygen species via AT1R/eNOS (show NOS3 Proteins)/NO signaling pathway.
Low AGTR1 expression is associated with chemoresistance of osteosarcoma.
No relationship was found between the studied polymorphisms (14094 ACE (show ACE Proteins) gene, rs1800469 gene TGFbeta1 (show TGFB1 Proteins), GNB3 (show GNB3 Proteins) gene rs5443, rs5186 AGTR1 gene) and the occurrence of primary vesicoureteral reflux.
Angiotensin II type 1 receptors promote ADAM17 (show ADAM17 Proteins)-mediated ACE2 (show ACE2 Proteins) shedding in the brain of hypertensive patients.
Data suggest that allosteric communication between heterodimeric AT1R and PTGFR is mediated through GNAQ and may also involve proximal phospholipase C but not distal protein kinase C signaling partners; PTGFR activation has negligible effects on AT1R-based conformational biosensors. (AT1R = angiotensin II receptor, type 1; PTGFR = prostaglandin F2alpha receptor; GNAQ = GTP-binding protein G[q] subunit alpha)
our results show the pivotal mechanisms of AT1R-induced harmful phenotype of Plasmodium-specific CD8 (show CD8A Proteins)(+) T cells during blood-stage malaria.
Ouabain stimulates NKA (show TAC1 Proteins) in renal proximal tubule cells through an angiotensin/AT1R-dependent mechanism and that this pathway contributes to cardiac glycoside associated hypertension.
Mutations within transmembrane domains IV, V, VI, and VII (show TH Proteins) had no effect on angiotensin-mediated beta-arrestin1 (show ARRB1 Proteins) recruitment; however, they exhibited differential effects on the assembly of AT1R into oligomeric complexes.
Our findings provide evidence that induction of APP (show APP Proteins) shedding via Ang II (show AGT Proteins)/AT1 receptor (show AGTRAP Proteins) stimulation is effected by G protein activation with Gbg (show CFB Proteins) subunits playing important roles.
This study aimed to define whether sex chromosome complement (SCC (show CYP11A1 Proteins)) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2 (show AGTR2 Proteins), and Mas1 (show MAS1 Proteins) receptors at fore/hindbrain nuclei and at medulla/cortical kidney.
The formation of liver metastasis, in a mouse model of colorectal cancer, correlated with collagen deposition in the metastatic area, which was dependent on AT1a signaling.
Perivascular Adipose Tissue Angiotensin II Type 1a Receptor Promotes Vascular Inflammation and Aneurysm formation in apolipoprotein E (show APOE Proteins)-deficient (ApoE (show APOE Proteins)(-/-)) mice.
The findings suggested that ox-LDL could induce cardiac hypertrophy through the direct association of AT1-R and LOX-1 (show OLR1 Proteins).
Mice lacking the AT1A receptor specifically in LEPR-expressing cells failed to show an increase in resting metabolic rate in response to a high-fat diet and deoxycorticosterone acetate-salt (DOCA-salt) treatments, but blood pressure control remained intact.
In wild-type, total (tNCC (show TNNC1 Proteins)) and phosphorylated (pNCC) NCC (show SLC12A3 Proteins) protein expressions were 1.8- and 4.6-fold higher in females compared with males, consistent with the larger response to HCTZ. In AT1a receptor knockout mice, tNCC (show TNNC1 Proteins) and pNCC increased significantly in males to levels not different from those in females.
This study showed that activation of the AT1a receptor may contribute to maintenance of the glomerular structure against hypertensive renal damage.
Altered expression of AT1 and AT2 receptors with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration.
Results provide evidence that blockade of the AT1a receptor could have some effects on browning of WAT, with inhibitory effects on adipose tissue-derived stem cells differentiation into adipocytes.
Results suggest the involvement of angiotensin II (Ang II), through its angiotensin type-1 receptor (AT1R (show AGTRAP Proteins)) in the inflammation induced by Aah (show ASPH Proteins) venom, in the heart and the aorta.
Data suggest that AGTR2 (show AGTR2 Proteins) (and angiotensin-converting enzyme (show ACE Proteins)) mRNA levels are transiently up-regulated in ovarian theca cells during preovulatory period.
These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II (show AGT Proteins) receptor activation is transduced to depolarization-dependent Ca(2 (show CA2 Proteins)+) entry and aldosterone secretion.
Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.
data suggest that G alpha(i3), Shc (show SHC1 Proteins), Grb2 (show GRB2 Proteins), Ras, and Raf-1 (show RAF1 Proteins) link Src (show SRC Proteins) to activation of MAPK (show MAPK1 Proteins) and to the AT(2)-dependent increase in eNOS (show NOS3 Proteins) expression in PAECs
Abundance of AGTR2 (show AGTR2 Proteins) mRNA in granulosa cells was higher in healthy compared with atretic follicles, whereas in theca cells, it did not change
transcripts for the ANGII receptor type 1 (ATR1) were detected in lungs of Xenopus laevis
Ang II (show AGT Proteins) increase HTFs proliferation, migration, and phenotype transition, suggesting that Ang II (show AGT Proteins) may play a role in wound healing after trabeculectomy.
Renal AT1R expression was increased by approximately 67% and AT2R (show AGTR2 Proteins) expression was decreased by approximately 87% in rabbits with heart failure; however, kidneys from denervated rabbits with heart failure showed a near normalization in the expression of these receptors.
Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia (show RNF111 Proteins)-mediated downregulation of Smad7 (show SMAD7 Proteins).
Following inflammation in the femoral artery angiotensin AT1 receptors are activated along with thromboxane receptors.
Corneal cells express ACE (show ACE Proteins), AT(1) and AT(2)receptors. ACE (show ACE Proteins) inhibitor enalapril decreased corneal angiogenesis in VEGF (show VEGFA Proteins)-induced corneal neovascularization. ACE (show ACE Proteins) inhibitors may be novel therapy to treat corneal angiogenesis.
investigated whether oxidant stress plays a role in Ang II-induced AT1R upregulation and its relationship to the transcription factor activator protein 1 (AP1) in CHF rabbits and in the CATHa neuronal cell line
Luminal ANG II is internalized as a complex with AT1R/AT2R heterodimers to target endoplasmic reticulum in LLC-PK1 cells, where it might trigger intracellular calcium responses.
AT1 and AT2 (show AGTR2 Proteins) receptors heterodimerize and are involved in the angiotensin II effect on SERCA (show ATP2A3 Proteins) in proximal kidney tubules.
A critical role for lipid raft microdomains in AGTR1-mediated signal transduction in neonatal glomerular mesengial cells.
AT1 receptors are positively coupled to the proliferative response of vascular smooth muscle cells to angiotensin II.
Glomerular eNOS (show NOS3 Proteins) gene expression was studied during postnatal maturation and AT1 receptor (show AGTRAP Proteins) inhibition.
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed\; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
type-1 angiotensin II receptor
, type-1B angiotensin II receptor
, angiotensin II type-1A receptor
, angiotensin receptor 1
, angiotensin receptor 1a
, type-1A angiotensin II receptor
, Angiotensin II receptor, type 1 (AT1B)
, angiotensin II receptor, type-1
, angiotensin II type-1 receptor
, angiotensin II type-1B receptor
, angiotensin receptor 1b
, angiotensin II receptor 1
, angiotensin 2 receptor, type 1, gene 2
, angiotensin 2 receptor, type 1-B
, angiotensin II receptor, type 1
, angiotensin II receptor, type 1-B
, angiotensin II type-1 receptor 2
, angiotensin type 1 receptor
, type-1 angiotensin II receptor B
, type-1-like angiotensin II receptor 2
, angiotensin II type 1 receptor
, AT1 ANG II receptor
, AT1 angiotensin II receptor
, Type-1 angiotensin II receptor
, angiotensin receptor
, angiotensin II receptor type 2
, angiotensin II type 2 receptor
, angiotensin receptor 2
, angiotensin II receptor, type 2
, type-2 angiotensin II receptor
, angiotensin type II receptor
, type-2 angiotensin II receptor-like
, Type-2 angiotensin II receptor
, angiotensin II subtype 2 receptor, AT2
, Angiotensin II type-1 receptor
, Angiotensin 2 receptor, type 1-A
, Angiotensin II receptor, type 1-A
, Type-1-like angiotensin II receptor 1
, angiotensin 2 receptor, type 1 L homeolog
, angiotensin 2 receptor, type 1-A
, angiotensin II receptor, type 1-A
, angiotensin II type-1 receptor 1
, angiotensin type 1
, type-1 angiotensin II receptor A