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Intracrine action of angiotensin II in mesangial cells: subcellular distribution of angiotensin II receptor subtypes AT1 and AT2.
Meta-analysis suggests that AGTR1 A1166C polymorphism may increase the susceptibility to diabetic nephropathy.
Results may indicate that the choice of diet can undermine the potential genetic risk of the AT1R 1166A>C polymorphism for MetS (show ETV3 Proteins), and persons who are variant carriers may spontaneously choose the Mediterranean diet.
The research reveals that among patients with essential hypertension treated with hypotensive drugs there are certain relationships between the rs5182 and rs5186 polymorphisms of the AGTR1 gene, as well as between the rs1799998 polymorphism of the CYP11B2 (show CYP11B2 Proteins) gene and the volume of the carotid bodies.
The protective effects of short-term hypoxia (STH) are associated with the upregulation of MasR to inhibit AT1 R signaling. STH could be a potential therapeutic strategy for cardiac diseases in hypertensive patients.
A high level of ART1 (show ART1 Proteins) antibodies was a risk factor for allograft function in kidney transplant recipients.
we found an interaction between ACE2 and AGTR1 in structuralatrial fibrillation patients in a Chinese Han population
AGTR1 DNA hypomethylation is a risk factor for the development of hypertension. Furthermore, there is a correlation between smoking, diet, and AGTR1 DNA methylation (show HELLS Proteins) levels.
Chinese Han persons with C allele of rs9817428 in PPARG (show PPARG Proteins) gene were related to the increased risk of hypertension.
Results showed no association between genotypes and preeclampsia for polymorphisms rs5186, rs4606 in 3'UTR of genes ACVR2A (show ACVR2A Proteins), AGTR1 and RGS2 (show RGS2 Proteins) in women with preeclampsia
GPCR (show GPBAR1 Proteins)-arrestin (show SAG Proteins) complex initiates non-desensitized signalling at the plasma membrane by coupling with ion channels.
the expression of AT2 (show AGTR2 Proteins) receptors was significantly increased compared to that of AT1 (show SLC33A1 Proteins) receptors upon ischemic induction.
Transforming growth factor-beta1 induces cerebrovascular dysfunction and astrogliosis through angiotensin II type 1 receptor-mediated signaling pathways
High AT1R (show AGTRAP Proteins) expression is associated with acute lung injury.
QLQX may improve diabetic cardiac function by regulating AGTR1/ TRPV1-mediated autophagy in STZ-induced diabetic mice.
Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms.
AT1R (show AGTRAP Proteins) in antigen-specific CD8 (show CD8A Proteins)(+) T cells regulates expansion, differentiation, and function during effector and memory phases of the response against Plasmodium, which could apply to different infectious agents.
Nrf2 (show NFE2L2 Proteins)-mediated stimulation of intrarenal Renin (show REN Proteins)-angiotensin system gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes.
This study aimed to define whether sex chromosome complement (SCC (show CYP11A1 Proteins)) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2 (show AGTR2 Proteins), and Mas1 (show MAS1 Proteins) receptors at fore/hindbrain nuclei and at medulla/cortical kidney.
The formation of liver metastasis, in a mouse model of colorectal cancer, correlated with collagen deposition in the metastatic area, which was dependent on AT1a signaling.
These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II (show AGT Proteins) receptor activation is transduced to depolarization-dependent Ca(2 (show CA2 Proteins)+) entry and aldosterone secretion.
Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.
transcripts for the ANGII receptor type 1 (ATR1) were detected in lungs of Xenopus laevis
Ang II (show AGT Proteins) increase HTFs proliferation, migration, and phenotype transition, suggesting that Ang II (show AGT Proteins) may play a role in wound healing after trabeculectomy.
Renal AT1R expression was increased by approximately 67% and AT2R (show AGTR2 Proteins) expression was decreased by approximately 87% in rabbits with heart failure; however, kidneys from denervated rabbits with heart failure showed a near normalization in the expression of these receptors.
Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia (show RNF111 Proteins)-mediated downregulation of Smad7 (show SMAD7 Proteins).
Following inflammation in the femoral artery angiotensin AT1 receptors are activated along with thromboxane receptors.
Corneal cells express ACE (show ACE Proteins), AT(1) and AT(2)receptors. ACE (show ACE Proteins) inhibitor enalapril decreased corneal angiogenesis in VEGF (show VEGFA Proteins)-induced corneal neovascularization. ACE (show ACE Proteins) inhibitors may be novel therapy to treat corneal angiogenesis.
investigated whether oxidant stress plays a role in Ang II-induced AT1R upregulation and its relationship to the transcription factor activator protein 1 (AP1) in CHF rabbits and in the CATHa neuronal cell line
Luminal ANG II is internalized as a complex with AT1R/AT2R heterodimers to target endoplasmic reticulum in LLC-PK1 cells, where it might trigger intracellular calcium responses.
AT1 and AT2 (show AGTR2 Proteins) receptors heterodimerize and are involved in the angiotensin II effect on SERCA (show ATP2A3 Proteins) in proximal kidney tubules.
A critical role for lipid raft microdomains in AGTR1-mediated signal transduction in neonatal glomerular mesengial cells.
AT1 receptors are positively coupled to the proliferative response of vascular smooth muscle cells to angiotensin II.
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed\; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
type-1 angiotensin II receptor
, type-1B angiotensin II receptor
, angiotensin II type-1A receptor
, angiotensin receptor 1
, angiotensin receptor 1a
, type-1A angiotensin II receptor
, angiotensin II receptor 1
, angiotensin II type-1 receptor
, angiotensin 2 receptor, type 1, gene 2
, angiotensin 2 receptor, type 1-B
, angiotensin II receptor, type 1
, angiotensin II receptor, type 1-B
, angiotensin II type-1 receptor 2
, angiotensin type 1 receptor
, type-1 angiotensin II receptor B
, type-1-like angiotensin II receptor 2
, angiotensin II type 1 receptor
, AT1 ANG II receptor
, AT1 angiotensin II receptor
, Type-1 angiotensin II receptor
, angiotensin receptor
, Angiotensin II type-1 receptor
, Angiotensin 2 receptor, type 1-A
, Angiotensin II receptor, type 1-A
, Type-1-like angiotensin II receptor 1
, angiotensin 2 receptor, type 1 L homeolog
, angiotensin 2 receptor, type 1-A
, angiotensin II receptor, type 1-A
, angiotensin II type-1 receptor 1
, angiotensin type 1
, type-1 angiotensin II receptor A