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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN2017902
Djalilian, Caicedo, Lessan, Grami, Le, Spellman, Pambuccian, Hall, Low, Ondrey: Efficacy of an osmotic pump delivered, GM-CSF-based tumor vaccine in the treatment of upper aerodigestive squamous cell carcinoma in rats. in Cancer immunology, immunotherapy : CII 2007
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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN803898
Carreño, Pacheco, Gutierrez, Jacobelli, Kalergis: Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells. in Immunology 2010
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Mouse (Murine) CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN803901
Bråve, Ljungberg, Boberg, Rollman, Isaguliants, Lundgren, Blomberg, Hinkula, Wahren: Multigene/multisubtype HIV-1 vaccine induces potent cellular and humoral immune responses by needle-free intradermal delivery. in Molecular therapy : the journal of the American Society of Gene Therapy 2005
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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN934919
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
Upregulation of GM-CSF and M-CSF (show CSF1 Proteins) production by endothelial cells, an effect that appears to be mediated by NF-kappaB (show NFKB1 Proteins) and to be independent of IL-1 (show IL1A Proteins), may be an additional mechanism through which IL-33 (show IL33 Proteins) contributes to inflammatory activation of the vessel wall.
Oral and periodontal innate immunity is affected by HIV viremia and ART. GCF (show GUCY2F Proteins) IL-8 (show IL8 Proteins), G-CSF (show CSF3 Proteins), as well as serum IL-8 (show IL8 Proteins), MCP-1 (show CCL2 Proteins) and GM-CSF may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use.
Data suggest that the intratumoral GM-CSF expression, as a potentially independent prognostic biomarker for recurrence, might improve conventional clinical and pathologic analysis to refine outcome prediction for clinically localized clear-cell renal cell carcinoma (show MOK Proteins) (ccRCC) patients after surgery.
High GM-CSF expression is associated with breast Cancer.
In gastric cancer (GC), tumour-derived GM-CSF activated neutrophils and induced neutrophil PD-L1 (show CD274 Proteins) expression via Janus kinase (JAK (show JAK3 Proteins))-signal transducer and activator of transcription 3 (STAT3 (show STAT3 Proteins)) signalling pathway. The activated PD-L1 (show CD274 Proteins)(+) neutrophils effectively suppressed normal T-cell immunity in vitro and contributed to the growth and progression of human GC in vivo.
The IL-3 (show IL-3 Proteins)/ GM-CSF effected on the myofibroblastic differentiation of human adipose derive stromal cells (hASCs) as well as it did on human dermal fibroblasts (HDFs).
Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 (show IL5 Proteins) and GM-CSF.
Data suggest that the methylotrophic yeast Pichia pastoris is an effective recombinant host for heterologous granulocyte-macrophage colony-stimulating factor (rhGM-CSF) production.
Letter: Knockdown of either filaggrin (show FLG Proteins) or loricrin (show LOR Proteins) increases the productions of interleukin (IL)-1alpha, IL-8 (show IL8 Proteins), IL-18 (show IL18 Proteins) and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes.
Impaired RASGRF1 (show RASGRF1 Proteins)/ERK (show EPHB2 Proteins)-mediated GM-CSF response characterizes CARD9 (show CARD9 Proteins) deficiency in French-Canadians.
TRAF6 (show TRAF6 Proteins) is also required for GM-CSF-induced ubiquitination and activation of Akt (show AKT1 Proteins).
CSF2 stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (show MAPK1 Proteins)-dependent MTOR (show FRAP1 Proteins) signal transduction cascades.
this study demonstrates that epithelial-derived GM-CSF is a critical early signal during allergic sensitization to cockroach allergen
These impaired macrophage functions in leukemic mice were significantly corrected by IL-3 (show IL-3 Proteins) and GM-CSF treatment indicating the therapeutic benefit of these two cytokines in leukemia.
Both IL-6 (show IL6 Proteins) protein production and transcript levels were downregulated by RA in respiratory tract epithelial cells (LETs) , but upregulated in macrophages (MACs). RA also increased transcript levels of MCP-1 (show CPT1B Proteins), GMCSF, and IL-10 (show IL10 Proteins) in MACs, but not in LETs. Conversely, when LETs, but not MACs, were exposed to RA
T-GM-CSF and -IL-3 (show IL-3 Proteins) significantly, and reciprocally, blunted receptor binding and myeloid progenitor cell proliferation activity of both FL-GM-CSF and -IL-3 (show IL-3 Proteins) in vitro and in vivo
Results indicate GM-CSF as both a key contributor to the pathogenesis of MI and a potential therapeutic target.
GM-CSF is required for the normal balance of leukocyte subsets, including granulocytes, B cells, and naive vs. effector T cells. There was an approximately 3-fold increase in the percentages of granulocytes in Csf2-/- PBMCs. The presence of maximal experimental autoimmune encephalomyelitis in the complete absence of GM-CSF revealed that GM-CSF is not an obligate effector molecule in all forms of EAE.
chemerin (show RARRES2 Proteins) inhibited nuclear factor-kappaB activation and the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (show IL2 Proteins) (IL-6 (show IL6 Proteins)) by tumor cells and tumor-associated endothelial cell, respectively, via its receptors, and consequently, MDSC induction was impaired, leading to restoration of antitumor T-cell response and decreased tumor angiogenesis.
These findings describe a novel role for GM-CSF as an essential initiating cytokine in cardiac inflammation.
Data reviewed establish that any damage to brain tissue tends to cause an increase in G-CSF (show CSF3 Proteins) and/or GM-CSF (G(M)-CSF (show CSF1R Proteins)) synthesized by the brain. Glioblastoma cells themselves also synthesize G(M)-CSF (show CSF1R Proteins). G(M)-CSF (show CSF1R Proteins) synthesized by brain due to damage by a growing tumor and by the tumor itself stimulates bone marrow to shift hematopoiesis toward granulocytic lineages away from lymphocytic lineages.
These results demonstrated that bovine colonic cells seem capable to respond to E. bovis merozoite I infection by the upregulation of CXCL10 (show CXCL10 Proteins) and GM-CSF gene transcription.
Data suggest exposure to maternal CSF2 from D5-D7 of development is fundamentally different for female/male blastocysts with respect to embryo elongation, characteristics of transcriptome/methylome, and endometrial interferon tau secretion at D15 (show MRPL16 Proteins).
The increase in calving rate caused by CSF2 treatment involves, in part, more extensive development of extraembryonic membranes and capacity of the conceptus to secrete IFNT2 at day 15 of pregnancy.
immunolocalization studies confirmed the presence of granulocyte-macrophage colony stimulating factor(GM-CSF) in the germ cell line in bovine and human testes and addition of GM-CSF enhances several parameters of sperm motility
the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 (show PTGS2 Proteins) and GM-CSF during the peri (show PLIN1 Proteins)-attachment period in the cow.
CSF2 affect embryonic development and enhance embryo competence for posttransfer survival.
Data indicate that differentially expressed IL-17 (show IL17A Proteins), IL-22 (show IL22 Proteins), and IL-23 (show IL23A Proteins) levels are associated with K-ras (show HRAS Proteins) in a stage-specific fashion along colorectal cancer progression and an association was established between mutant K-ras (show HRAS Proteins) and GM-CSF and IFN-gamma (show IFNG Proteins).
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.
, granulocyte-macrophage colony-stimulating factor
, colony stimulating factor 2 (granulocyte-macrophage)
, colony-stimulating factor
, granulocyte-macrophage colony stimulating factor 2
, put. GM-CSF
, granulate-macrophage stimulating factor
, granulocyte-macrophage stimulation factor