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anti-Rat (Rattus) CSF2RB Antibodies:
anti-Human CSF2RB Antibodies:
anti-Mouse (Murine) CSF2RB Antibodies:
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Human Monoclonal CSF2RB Primary Antibody for FACS, IP - ABIN967466
Woodcock, Zacharakis, Plaetinck, Bagley, Qiyu, Hercus, Tavernier, Lopez: Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. in The EMBO journal 1994
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Human Monoclonal CSF2RB Primary Antibody for FACS - ABIN2688952
Zola, Swart, Banham, Barry, Beare, Bensussan, Boumsell, D Buckley, Bühring, Clark, Engel, Fox, Jin, Macardle, Malavasi, Mason, Stockinger, Yang: CD molecules 2006--human cell differentiation molecules. in Journal of immunological methods 2007
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Human Polyclonal CSF2RB Primary Antibody for CyTOF, FACS - ABIN4899754
Lei, Mazumdar, Martinez-Moczygemba: Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling. in The Journal of biological chemistry 2011
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Human Polyclonal CSF2RB Primary Antibody for FACS - ABIN4896606
van Nieuwenhuijze, Coghill, Gray, Prato, Metcalf, Alexander, Wicks: Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis. in The American journal of pathology 2013
SYK (show SYK Antibodies) mediates the actions of EPO (show EPO Antibodies) and GM-CSF (show CSF2 Antibodies) and coordinates with TGF-beta (show TGFB1 Antibodies) in erythropoiesis.
Exome sequencing identified candidate variants, including a missense mutation in DUOX2 (show DUOX2 Antibodies) that impaired its function and a frameshift mutation in CSF2RB that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals.
In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor (show CSF2 Antibodies), providing an additional mechanism for alterations to the innate immune response in individuals with Crohn's Disease.
VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF (show CSF2 Antibodies) and MED14 (show MED14 Antibodies)
These data suggest that expression of GM-CSF (show CSF2 Antibodies) and its receptor subunits by colon tumors may be a useful marker for prognosis
This study reveals a novel functional role of clathrin-coated structure in GMR (show CSF2RA Antibodies) signaling and the oncogenesis of JAK2V617F.
JAK (show JAK3 Antibodies) kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling.
Granulocyte/macrophage colony-stimulating factor (show CSF2 Antibodies) causes a paradoxical increase in the BH3-only (show BBC3 Antibodies) pro-apoptotic protein Bim (show BCL2L11 Antibodies) in human neutrophils
The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population.
Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report]
IL-3 (show IL-3 Antibodies) signaling does not contribute to Jak2 (show JAK2 Antibodies) V617F myeloproliferative neoplasm pathogenesis.
blockage of betaCR abrogated the EPO (show EPO Antibodies)-conferred anti-inflammatory action on oxLDL-induced production of macrophage inflammatory protein-2 (show CXCL2 Antibodies)
Deletion of the Csf2rb gene slows the progression of chronic myelomonocytic leukemia in mice.
Increased levels of Csf2rb on hematopoietic stem cells lead to expansion of these populations in ApoE (show APOE Antibodies)(-/-) BM-transplanted Ldlr (show LDLR Antibodies)(-/-) mice, contributing to monocytosis and increased lesional macrophage content.
Erythropoietin (show EPO Antibodies) attenuates the impaired systolic contractility associated with sepsis by activation of the beta-common receptor.
Findings indicate that SLP-76 (show LCP2 Antibodies) is an essential signaling component for basophil activation downstream of both FcepsilonRI (show FCER1A Antibodies) and the IL-3 (show IL-3 Antibodies) receptor.
Csf-2 (show CSF2 Antibodies) receptor acts in the steady state to promote the survival & homeostasis of nonlymphoid tissue-resident CD103 (show ITGAE Antibodies)(+) & CD11b (show ITGAM Antibodies)(+) DCs. It is dispensable for the differentiation & innate function of inflammatory DCs during acute injuries.
GM-CSF (show CSF2 Antibodies) can regulate beta-catenin (show CTNNB1 Antibodies) stability, most likely via GSK3b (show GSK3b Antibodies).
Suggest that beta common receptor may play an integrative role in the erythropoietin (show EPO Antibodies) signaling-mediated activation of eNOS (show NOS3 Antibodies) in endothelial cells.
NF-kappaB (show NFKB1 Antibodies) activation by beta(c) is dependent on TNFR (show TNFRSF1A Antibodies)-associated factor (TRAF)6 (show TRAF6 Antibodies); association of TRAF6 (show TRAF6 Antibodies) with beta(c) requires a consensus-binding motif found in other molecules known to interact with TRAF6 (show TRAF6 Antibodies).
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP).
cytokine receptor common subunit beta
, interleukin 3 common beta chain
, colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)
, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
, interleukin 3 receptor beta common
, cytokine receptor common subunit beta-like
, GM-CSF/IL-3/IL-5 receptor common beta subunit
, GM-CSF/IL-3/IL-5 receptor common beta-chain
, colony-stimulating factor-2 receptor, beta, low-affinity
, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
, CD131 antigen
, beta c
, common beta chain
, interleukin-5 receptor beta chain