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anti-Human FYN Antibodies:
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Human Monoclonal FYN Primary Antibody for ICC, IF - ABIN269149
Taniguchi, Xia, Goldberg, Lee, Shah, Stavar, Masson, Momen, Shikatani, John, Husain, Fantus: Inhibition of Src kinase blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells and prevents diabetic nephropathy in mice. in Diabetes 2013
Show all 4 Pubmed References
Human Monoclonal FYN Primary Antibody for ICC, FACS - ABIN969159
Brignatz, Paronetto, Opi, Cappellari, Audebert, Feuillet, Bismuth, Roche, Arold, Sette, Collette: Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn. in Molecular and cellular biology 2009
Show all 3 Pubmed References
Human Monoclonal FYN Primary Antibody for ELISA, WB - ABIN969160
Kitkumthorn, Yanatatsanajit, Kiatpongsan, Phokaew, Triratanachat, Trivijitsilp, Termrungruanglert, Tresukosol, Niruthisard, Mutirangura: Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer. in BMC cancer 2006
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Human Monoclonal FYN Primary Antibody for IHC (fro), IP - ABIN2473714
Borok, Farina, Leider: Radiotherapy for Kaposi's sarcoma. in The Journal of dermatologic surgery and oncology 1979
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Human Monoclonal FYN Primary Antibody for WB - ABIN1944798
Kawakami, Pennington, Robbins: Isolation and oncogenic potential of a novel human src-like gene. in Molecular and cellular biology 1987
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Human Monoclonal FYN Primary Antibody for ICC, IHC (p) - ABIN94311
Queval, Nicolas, Beau: Role of Src kinases in mobilization of glycosylphosphatidylinositol-anchored decay-accelerating factor by Dr fimbria-positive adhering bacteria. in Infection and immunity 2011
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Human Polyclonal FYN Primary Antibody for PLA, WB - ABIN515873
Liu, Chen, Chau, Jan, Chen, Hsu, Lin, Juang, Lu, Cheng, Chen, Chang, Ting, Kao, Hsiao, Huang: Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma. in Molecular & cellular proteomics : MCP 2013
Human Monoclonal FYN Primary Antibody for FACS, IF - ABIN966166
Lu, Zhu, Cvrljevic, Huang, Sarkaria, Ahkavan, Dang, Dinca, Plaisier, Oderberg, Lee, Chen, Caldwell, Xie, Loo, Seligson, Chakravari, Lee, Weinmann, Cloughesy, Nelson, Bergers, Graeber, Furnari, James, Cavenee, Johns, Mischel: Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. in Cancer research 2009
Show all 2 Pubmed References
Human Polyclonal FYN Primary Antibody for IHC, IHC (p) - ABIN4312914
Miyamoto, Torii, Takada, Ohno, Saitoh, Nakamura, Ito, Ogata, Terada, Tanoue, Yamauchi: Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination. in Molecular biology of the cell 2015
We also show that activation and reduction of Fyn kinase in oligodendrocytes increases and decreases sheath number per cell, respectively.
Yes kinase plays an important role in epiboly and indicate that Yes kinase participates in signaling by focal adhesion kinase during early development.
Fyn kinase plays an important role in epiboly during zebrafish development, possibly through its effects in calcium signaling.
Fyn, and possibly other Src (show SRC Antibodies) family members are activated by dephosphorylation of the C-terminal tyrosine at fertilization
investigated signaling pathways in early development by comparison of the phosphoproteome of wild type embryos with Fyn/Yes knockdown embryos that display specific convergence and extension cell movement defects
Fyn binds to mGluR1a (show GRM1 Antibodies) at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a (show GRM1 Antibodies) in vitro. Active Fyn phosphorylates mGluR1a (show GRM1 Antibodies) at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a (show GRM1 Antibodies) is constitutively active and facilitates surface expression of mGluR1a (show GRM1 Antibodies) and potentiates mGluR1a (show GRM1 Antibodies) postreceptor signaling.
High FYN expression is associated with pancreatic cancer metastasis.
Study was the first to demonstrate critical positive regulation of thyroid tumorigenesis by FYN, which could be a potential target gene for thyroid carcinoma treatment.
Fyn-dependent phosphorylation of SHP-1 serine 591 inactivates the phosphatase, enabling activatory immunoreceptor signaling.
upregulated in fibrotic kidneys
Study identified the binding site between tau and fyn-SH3 may facilitate the development of compounds that can inhibit tau-fyn interactions, which presents an alternative therapeutic strategy for Alzheimer's disease; and provide evidence that a physiological correlation between phosphorylated tau at S202, S262, and S396/404 and fyn is not present in Alzheimer's disease brain.
FYN expression is regulated according to AD status and regulatory region haplotype, and genetic variants may be instrumental in the development of neurofibrillary tangles in AD and other tauopathies.
a substantial fraction of unligated CD36 (show CD36 Antibodies) exists in nanoclusters, which not only promote TSP-1 (show THBS1 Antibodies) binding but are also enriched with the downstream effector Fyn.
Upon SMAD4 (show SMAD4 Antibodies) deletion, we detected high expression levels of FYN in vessel endothelial cells, suggesting the mechanism of the ovarian tumor cells cross the endothelial barrier and transform to an invasive phenotype
Study reveal that binding the phosphorylated tail of Fyn perturbs a residue cluster near the linker connecting the SH2 and SH3 domains of Fyn, which is known to be relevant in the regulation of the activity of Fyn.
We conclude that the hypoxia-induced activation of caspase-9 (show CASP9 Antibodies) is mediated by Src kinase (show CSK Antibodies).
Fyn oncogene (show RAB1A Antibodies) alternative spliced forms have been isolated from brain and spleen.
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.
PECAM-1 (show PECAM1 Antibodies) and Fyn are essential components of a PECAM-1 (show PECAM1 Antibodies)-based mechanosensory complex in endothelial cells.
This study reported that suppression of Fyn expression in mouse cerebral cortex led to migration defects of both early-born and late-born neurons.
ATF3 (show ATF3 Antibodies) inhibit the expression and release of TNF-alpha (show TNF Antibodies), IL-1beta (show IL1B Antibodies), IL-6 (show IL6 Antibodies), and IL-18 (show IL18 Antibodies) induced by Mycoplasma pneumonia in vitro and in vivo, which is associated with its negative regulation of Egr-1 (show EGR1 Antibodies)/Fyn signaling pathway.
The results of this study suggested the existence of a potential DEP-1 (show PTPRJ Antibodies)-Fyn axis in the regulation of microglial functions.
These results suggested that Fyn has a regulatory role in iNOS (show NOS2 Antibodies) expression in astrocytes during neuroinflammatory responses.
Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.
loss of Fyn in the kidney prevents unilateral ureteral obstruction-induced tubulointerstitial fibrosis, mediated by a reduction in STAT3 (show STAT3 Antibodies) phosphorylation
results show that Fyn kinase is an important positive effector of TGF-beta (show TGFB1 Antibodies)-induced chemotaxis through the control of phosphatase PP2A (show PPP2R2B Antibodies) activity and this is relevant to pathological processes that are related to TGF-beta (show TGFB1 Antibodies)-dependent mast cell migration
In summary,MAGI-2 (show MAGI2 Antibodies) and Fyn protect dendrin from Nedd4-2 (show NEDD4L Antibodies)-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes.
FYN is activated by oxidative stress and serves as a negative feedback regulator of NOX4 (show NOX4 Antibodies) in cardiomyocytes during cardiac remodeling
The results of this study suggested that Fyn-mediated NR2B (show GRIN2B Antibodies) signaling plays a critical role in regulation of prediabetic neuropathy and that the increased expression/function of NR2B (show GRIN2B Antibodies) subunit-containing NMDARs may contribute to the progression of neuropathy in type 2 diabetes
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
protein-tyrosine kinase fyn
, proto-oncogene tyrosine-protein kinase fyn
, Fyn non-receptor tyrosine kinase
, proto-oncogene c-Fynb
, tyrosine-protein kinase fynb
, FYN oncogene related to SRC, FGR, YES
, proto-oncogene tyrosine-protein kinase fyn-like
, tyrosine-protein kinase Fyn-like
, proto-oncogene c-Fyn
, proto-oncogene tyrosine-protein kinase Fyn
, tyrosine-protein kinase Fyn
, OKT3-induced calcium influx regulator
, c-syn protooncogene
, proto-oncogene Syn
, src-like kinase
, src/yes-related novel
, tyrosine kinase p59fyn(T)
, fyn proto-oncogene
, c-fyn, fyn proto-oncogene
, protein-tyrosine kinase
, proto-oncogene c-Fyna
, tyrosine-protein kinase fyna
, Src Kinase p59