Browse our anti-FYN (FYN) Antibodies

Zebrafish FYN Oncogene Related To SRC, FGR, YES (FYN) interaction partners

1. We also show that activation and reduction of Fyn kinase in oligodendrocytes increases and decreases sheath number per cell, respectively.

2. Yes kinase plays an important role in epiboly and indicate that Yes kinase participates in signaling by focal adhesion kinase during early development.

3. Fyn kinase plays an important role in epiboly during zebrafish development, possibly through its effects in calcium signaling.

4. Fyn, and possibly other Src (show SRC Antibodies) family members are activated by dephosphorylation of the C-terminal tyrosine at fertilization

5. investigated signaling pathways in early development by comparison of the phosphoproteome of wild type embryos with Fyn/Yes knockdown embryos that display specific convergence and extension cell movement defects

Human FYN Oncogene Related To SRC, FGR, YES (FYN) interaction partners

1. Fyn and Lyn (show LYN Antibodies) as important factors that promote Plasmacytoid dendritic cell responses.

2. Data suggest that Fyn tyrosine kinase (show TXK Antibodies) (Fyn)-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1 (show PLXNA1 Antibodies)) and plexin A2 (PlxnA2 (show Plxna2 Antibodies)) signal transduction.

3. Nav1.7 (show SCN9A Antibodies) is a substrate for Fyn kinase.

4. Fyn binds to mGluR1a (show GRM1 Antibodies) at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a (show GRM1 Antibodies) in vitro. Active Fyn phosphorylates mGluR1a (show GRM1 Antibodies) at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a (show GRM1 Antibodies) is constitutively active and facilitates surface expression of mGluR1a (show GRM1 Antibodies) and potentiates mGluR1a (show GRM1 Antibodies) postreceptor signaling.

5. High FYN expression is associated with pancreatic cancer metastasis.

6. Study was the first to demonstrate critical positive regulation of thyroid tumorigenesis by FYN, which could be a potential target gene for thyroid carcinoma treatment.

7. Fyn-dependent phosphorylation of SHP-1 serine 591 inactivates the phosphatase, enabling activatory immunoreceptor signaling.

8. upregulated in fibrotic kidneys

9. Study identified the binding site between tau and fyn-SH3 may facilitate the development of compounds that can inhibit tau-fyn interactions, which presents an alternative therapeutic strategy for Alzheimer's disease; and provide evidence that a physiological correlation between phosphorylated tau at S202, S262, and S396/404 and fyn is not present in Alzheimer's disease brain.

10. FYN expression is regulated according to AD status and regulatory region haplotype, and genetic variants may be instrumental in the development of neurofibrillary tangles in AD and other tauopathies.

Pig (Porcine) FYN Oncogene Related To SRC, FGR, YES (FYN) interaction partners

1. We conclude that the hypoxia-induced activation of caspase-9 (show CASP9 Antibodies) is mediated by Src kinase (show CSK Antibodies).

2. Fyn oncogene (show RAB1A Antibodies) alternative spliced forms have been isolated from brain and spleen.

Cow (Bovine) FYN Oncogene Related To SRC, FGR, YES (FYN) interaction partners

1. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.

2. PECAM-1 (show PECAM1 Antibodies) and Fyn are essential components of a PECAM-1 (show PECAM1 Antibodies)-based mechanosensory complex in endothelial cells.

Mouse (Murine) FYN Oncogene Related To SRC, FGR, YES (FYN) interaction partners

1. Fyn and Lyn (show LYN Antibodies) as important factors that promote Plasmacytoid dendritic cell responses.

2. these results suggest that Nrf2 (show NFE2L2 Antibodies) plays a central role in the prevention of Ang II (show AGT Antibodies)-induced cardiomyopathy, and SFN (show SFN Antibodies) prevents Ang II (show AGT Antibodies)-induced cardiomyopathy partially via the Akt (show AKT1 Antibodies)/GSK-3beta/Fyn-mediated Nrf2 (show NFE2L2 Antibodies) activation.

3. This study reported that suppression of Fyn expression in mouse cerebral cortex led to migration defects of both early-born and late-born neurons.

4. ATF3 (show ATF3 Antibodies) inhibit the expression and release of TNF-alpha (show TNF Antibodies), IL-1beta (show IL1B Antibodies), IL-6 (show IL6 Antibodies), and IL-18 (show IL18 Antibodies) induced by Mycoplasma pneumonia in vitro and in vivo, which is associated with its negative regulation of Egr-1 (show EGR1 Antibodies)/Fyn signaling pathway.

5. The results of this study suggested the existence of a potential DEP-1 (show PTPRJ Antibodies)-Fyn axis in the regulation of microglial functions.

6. These results suggested that Fyn has a regulatory role in iNOS (show NOS2 Antibodies) expression in astrocytes during neuroinflammatory responses.

7. Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.

8. loss of Fyn in the kidney prevents unilateral ureteral obstruction-induced tubulointerstitial fibrosis, mediated by a reduction in STAT3 (show STAT3 Antibodies) phosphorylation

9. results show that Fyn kinase is an important positive effector of TGF-beta (show TGFB1 Antibodies)-induced chemotaxis through the control of phosphatase PP2A (show PPP2R2B Antibodies) activity and this is relevant to pathological processes that are related to TGF-beta (show TGFB1 Antibodies)-dependent mast cell migration

10. In summary,MAGI-2 (show MAGI2 Antibodies) and Fyn protect dendrin from Nedd4-2 (show NEDD4L Antibodies)-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes.