FYN antibody (FYN Oncogene Related To SRC, FGR, YES) (AA 7-176)

Details for Product anti-FYN Antibody No. ABIN94311, Supplier: Log in to see
Antigen
  • im:6908851
  • si:dkey-119m7.5
  • zgc:109996
  • c-fyn
  • cfyn-a
  • SLK
  • SYN
  • p59-FYN
  • PKC
  • fyn
  • zgc:86720
  • AI448320
  • AW552119
  • FYN proto-oncogene, Src family tyrosine kinase
  • FYN proto-oncogene, Src family tyrosine kinase S homeolog
  • FYN proto-oncogene, Src family tyrosine kinase b
  • FYN proto-oncogene, Src family tyrosine kinase L homeolog
  • FYN proto-oncogene, Src family tyrosine kinase a
  • Fyn proto-oncogene
  • FYN
  • fyn.S
  • fynb
  • fyn.L
  • Fyn
  • fyna
Alternatives
anti-Human FYN antibody for Immunocytochemistry
Epitope
AA 7-176
38
37
23
12
11
11
10
7
6
5
5
5
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
263
169
63
10
8
7
5
5
5
5
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3
2
1
Host
Mouse
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110
19
Clonality (Clone)
Monoclonal ()
Conjugate
This FYN antibody is un-conjugated
10
10
9
9
9
7
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
268
141
88
53
34
32
29
25
7
4
4
2
2
2
2
Options
Supplier
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Supplier Product No.
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Immunogen Bacterially expressed recombinant fragment of human Fyn (aa 7-176).
Clone FYN-01
Isotype IgG2b
Specificity The antibody FYN-01 reacts with Fyn, a 59 kDa non-receptor Src-family protein tyrosine kinase.
Purification Purified from hybridoma culture supernatant by protein A-affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others FYN products on genomics-online (e.g. as negative or positive controls)
Antigen FYN Oncogene Related To SRC, FGR, YES (FYN)
Alternative Name FYN (FYN Antibody Abstract)
Background Fyn is a ubiquitously expressed Src-family protein tyrosine kinase with important roles e.g. in immune and nervous system. It regulates N-methyl-D-aspartate (NMDA) receptor functions, thus affecting various brain functions, and even many of its other substrates are important for neural migration, synaptic plasticity, oligodendrocyte differentiation, and axon growth and guidance. In immune system Fyn namely regulates the commitment of T cells to activation, is important in T cell anergy induction, promotes mast cell chemotaxis and reorganization of cytoskeleton and participates in mast cell activation. Fyn is also involved in embryonic stem cell growth and differentiation, associates with tubulin and may play roles in mitotic spindle formation.
Pathways JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Supplier Images
Immunoprecipitation (IP) image for anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 7-176) antibody (ABIN94311) Immunoprecipitation of Fyn from the lysate of T cells isolated from fresh buffy coats...
Immunofluorescence (IF) image for anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 7-176) antibody (ABIN94311) Immunofluorescence staining of Fyn in human primary fibroblasts using anti-Fyn (; gre...
Immunofluorescence (IF) image for anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 7-176) antibody (ABIN94311) Immunofluorescence staining of Fyn in human HeLa cell line using anti-Fyn
Immunofluorescence (IF) image for anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 7-176) antibody (ABIN94311) Immunofluorescence staining of Fyn in murine transformed fibroblasts using anti-Fyn (...
Product cited in: Queval, Nicolas, Beau: "Role of Src kinases in mobilization of glycosylphosphatidylinositol-anchored decay-accelerating factor by Dr fimbria-positive adhering bacteria." in: Infection and immunity, Vol. 79, Issue 7, pp. 2519-34, 2011 (PubMed).

Meraner, Horejsí, Wolpl, Fischer, Stingl, Maurer: "Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 4, pp. 2262-71, 2007 (PubMed).

Background publications Rivera, Olivera: "A current understanding of Fc epsilon RI-dependent mast cell activation." in: Current allergy and asthma reports, Vol. 8, Issue 1, pp. 14-20, 2008 (PubMed).

Makinodan, Manabe, Makinodan, Yamauchi, Matsuyoshi, Sakumura, Tatsumi, Wanaka: "A novel role for Fyn: change in sphere formation ability in murine embryonic stem cells." in: Neuroscience, Vol. 147, Issue 1, pp. 1-4, 2007 (PubMed).

Samayawardhena, Kapur, Craig: "Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells." in: Blood, Vol. 109, Issue 9, pp. 3679-86, 2007 (PubMed).

Filby, Seddon, Kleczkowska, Salmond, Tomlinson, Smida, Lindquist, Schraven, Zamoyska: "Fyn regulates the duration of TCR engagement needed for commitment to effector function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 7, pp. 4635-44, 2007 (PubMed).

Wu, Hsu, Gleichman, Baconguis, Coulter, Lynch: "Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems." in: The Journal of biological chemistry, Vol. 282, Issue 28, pp. 20075-87, 2007 (PubMed).

Hattori, Uchino, Isosaka, Maekawa, Iyo, Sato, Kohsaka, Yagi, Yuasa: "Fyn is required for haloperidol-induced catalepsy in mice." in: The Journal of biological chemistry, Vol. 281, Issue 11, pp. 7129-35, 2006 (PubMed).

Talmor-Cohen, Tomashov-Matar, Tsai, Kinsey, Shalgi: "Fyn kinase-tubulin interaction during meiosis of rat eggs." in: Reproduction (Cambridge, England), Vol. 128, Issue 4, pp. 387-93, 2004 (PubMed).

Utting, Priatel, Teh, Teh: "p59fyn (Fyn) promotes the survival of anergic CD4-CD8- alpha beta TCR+ cells but negatively regulates their proliferative response to antigen stimulation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 3, pp. 1540-6, 2001 (PubMed).

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