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Down-regulation of gamma(c) during early HIV/SIV infection may inhibit T-cell function, particularly of CD8(+) T cells, and, may be linked with immune failure and loss of viral containment.
This study identifies one novel mutation in the IL2RG gene and another, previously described mutation in the CYBB genes. It is the first report establishing a diagnosis of X-SCID and X-CGD using WES in Chinese patients.
New insights of common gamma chain in hematological malignancies.
this study shows that downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines
Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2- and IL-15-activated T-cells has been reported.
systematic scoping review highlights the many potential uses of soluble interleukin-2 receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
analysis of the contribution of IL2Rgamma to the dynamic formation of IL2-IL2R complexes
A deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency with an atypical phenotype
novel missense mutation in Japanese patient results in atypical X-linked severe combined immunodeficiency with the presence of T cells and NK cells and revertant somatic mosaicism
reversion of mutation in common lymphoid progenitor results in mild phenotype of SCID
High IL2RG expression is associated with Sezary syndrome.
Identification of a gammaC splice isoform revealed expression of soluble gammaC proteins (sgammaC). sgammaC directly interacted with surface IL-2Rbeta to suppress IL-2 signaling and to promote pro-inflammatory Th17 cell differentiation. [review]
Study show the detection of IL2RG mutations in 2 families with X-SCID and identified 2 novel mutations, confirming the X-SCID pedigrees.
Interleukin 2 receptor subunit gamma mutation is associated with X-linked severe combined immunodeficiency.
Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.
Results demonstrate that IL2Rgamma has an onogenic role in JAK3-mutation-positive leukemias.
findings suggest that over-expression of the IL2RG gene may be implicated in altered immune response in schizophrenia and contribute to the pathomechanisms of this disorder
this is the first report on a de novo mutation in the IL2RG gene in a patient born after IVF
In a patient with a novel IL2RG mutation, gene-reverted CD8+ T cells accumulate over time.
in humans, signaling through the gammac pathway is not required for prethymic lymphoid commitment or for DNA rearrangement.
we presented here a novel IL-2Rgammac mutation in a carrier and SCID patient presenting NK cells in the peripheral blood
Suggest that soluble common gamma chain may be one of the target molecules for the control of immunopathogenic progresses in COPD.
Results indicate that conjugated-interleukin-2 (IL2) protein derived from NKTR-214 occupy interleukin-2 (IL2) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 protein.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2-beta receptor response, to date classically described only in immune cells.
degree to which immune rejection contributes to these disappointing outcomes using an immunodeficient IL2 receptor gamma (IL2rgamma)-null mouse model, was examined.
We have confirmed the activation of human peripheral blood lymphocytes after being xenografted in immunodeficient Rag2-/-IL2Rgnull mice.
findings demonstrate that NOD SCID IL2R common gamma chain -/- mice are capable of engraftment of canine PBLs yet develop graft versus host disease similar to Hu-PBL-SCID mice
Human colon cancer xenografts propagated in NSG and NRG mice maintain structural fidelity while replacing human stromal cells with murine stromal cells.
The potential for dysregulated T cell and dendritic cell (DC) activation in the gamma(c)-deficient environment leading to allergic lung inflammation.
Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor.
gammac expression was required to signal the differentiation of MHC class I-specific thymocytes into CD8+ cytotoxic lineage T cells and into invariant natural killer T cells.
critical for intestinal T-cell reconstitution in humanized mice
analysis of multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor
Results indicated that the extracellular and transmembrane domains of gammaC and IL-13Ralpha1 controlled the magnitude of the intracellular signaling response to IL-4 and IL-13.
physiologic impact of CB hematopoietic progenitor cell hypofucosylation was investigated in vivo in NOD-SCID interleukin (IL)-2Rgamma(null) (NSG) mice
Letter: Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rgammanull Ins2Akita mice.
CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rgamma-/- (NSG) mice
IL-2 receptor complex has an essential protective role in immunity to blood-stage malaria. Protection is achieved by gammac cytokine family members signalling through the IL-2Rgammac.
Hematopoietic stem cells -infused HLA-DR4.NOD.Rag1knockout (KO) .IL-2RgammacKO mice developed a very high reconstitution rate (>90%) with long-lived and functional human T and B cells.
Results reflect the suppression of the leaky phenomenon in NOG mice through the inactivation of the IL-2Rgamma gene, which is commonly expressed in T and B cell growth factor receptors to IL-2, IL-4 and IL-7.
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
cytokine receptor common subunit gamma
, interleukin 2 receptor gamma
, interleukin 2 receptor, gamma (severe combined immunodeficiency)
, membrane receptor Il2rg
, interleukin 2 receptor, gamma
, CD132 antigen
, IL-2 receptor subunit gamma
, IL-2R subunit gamma
, common cytokine receptor gamma chain
, IL-2R gamma chain
, cytokine receptor common gamma chain
, interleukin-2 receptor gamma chain
, interleukin-2 receptor subunit gamma
, interleukin 2 receptor gamma chain
, common gamma chain
, gamma C receptor