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Human IL4 Receptor Protein expressed in Human Cells - ABIN2002785
Grabstein, Eisenman, Mochizuki, Shanebeck, Conlon, Hopp, March, Gillis: Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines. in The Journal of experimental medicine 1986
Show all 6 Pubmed References
IL-4 may play a role in coordinating the adrenal response to inflammatory stress.
Zebrafish IL-4Ralpha shares overall conserved structural features of the IL-4Ralpha family; IL-4Ralpha is distributed on B cells.
dimerization governed by two-dimensional ligand-receptor interactions with a critical role of the transmembrane domain
Interleukin-4 receptor subunit alpha (IL-4Ralpha) haplotypes for Val75Ile, Ser503Pro, and Arg576Gln are associated with measles Immunoglobulin G production in Mozambican children but not Australian children. IL-4Ralpha 503Pro is more prevalent in Mozambique vaccine failure cases compared with controls.
We consider that although no association was found among diverse SNPs from human IL-10 and IL-4 promoter regions and gastric cancer event, the present research provides insight into two possible biomarkers of immunological nature (increased level of serum IL-4) and genetic nature (presence of the IL-10, -G1082A SNP) related to this neoplasm in our population.
IL-4R plays an important role in regulating hepatocellular carcinoma (HCC)cell survival and metastasis, and regulates the activity of the JAK1/STAT6 and JNK/ERK1/2 signaling pathways. We therefore suggest that IL-4/IL-4R may be a new therapeutic target for HCC
IL4RA and ADAM33 variants may be risk markers of asthma exacerbations in type-2 inflammatory endotype. Precise endotyping may facilitate the identification of genetic risk markers of asthma exacerbations.
this study shows that the IL-4Ralpha polymorphism is associated with susceptibility to chronic immune thrombocytopenia
Here in this review, we discuss the structural details of IL-4 and IL-4Ralpha subunit and the structural similarities between IL-4 and IL-13. We also describe detailed chemistry of type-I and type-II receptor complexes and their signaling pathways. Furthermore, we elaborate the strength of type-II hetero dimer signals in response to IL-4 and IL-13.
Naive CD4+ Tconv cells from subjects with asthma bearing the IL4RR576 mutation show defective induction of iTreg cells and their skewing toward a TH17-like phenotype.
Result showed that exposure of Peripheral Blood-Mesenchymal Stem Cells (PB-MSCs) to Noggin was associated with changes in pattern of CD29/CD184 expression. The expression profile of CD29(+/-)/CD184(-) can be suggested as a robust signature for tracing differentiation of PB-MSCs into neuronal cells.
The promoter methylation levels of GATA3, IL-4, and TGF-beta were significantly higher in active VKH patients than in healthy individuals
results suggest that certain polymorphisms of IL4 and IL4R may affect susceptibility to gastrointestinal cancer [meta-analysis]
A positive association exists between the IL-4R Q551R polymorphism and occurrence of chronic periodontitis.
Single nucleotide polymorphism of IL-4Ralpha 175 V was linked to greater Atopic dermatitis risk at 2 to 3 years of age.
Study indicates that endogenously expressed IL-4 and IL-4Ralpha contribute to the malignant phenotype of pancreatic cancer cells by activating diverse pro-oncogenic signaling pathways.
Polymorphisms in promoter region of IL-4 but not IL-4RA genes confer susceptibility to juvenile idiopathic arthritis and may predispose individuals to adaptive immune responses.
IL-4Ralpha gene (I50V) polymorphism may play a role in development of eczema among Saudi children
The aim of this study was to evaluate the impact of the polymorphisms within interleukin 4 (rs2243250, rs2227284), interleukin 4 receptor alpha chain (rs1805010, rs1805011) and interleukin 13 (rs20541) genes on the incidence of allergic phenotype in Polish pediatric population.
IL-4 -590 and IL-4R Q551R gene polymorphisms are not associated with the susceptibility and the clinical pattern of alopecia areata in Saudi patients.
One IL-4R gene polymorphism (rs1801275) was associated with acute rejection. In addition, a separate IL-4R SNP (rs2107356) was statistically associated with graft dysfunction after kidney transplantation.
investigated five SNPs (C-589T and C-33T of IL4, G+2044A of IL13, A+1902G of IL4Ralpha, and A+896G of TLR4) in patients with adult onset asthma to evaluate their role in manifestation and severity of asthma
IL4R plays a role in some cases of recurrent airway obstruction.
The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling.
IL-4Ralpha signaling on dendritic cells promotes allergen-induced Th2 responses and eosinophil infiltration into the lung.
blockade of IL-4Ralpha signaling has an anti-inflammatory and anti-fibrotic effect during toxin-induced liver fibrosis progression and retards - but does not prevent - fibrosis resolution.
IL-4Delta2 did not compete with IL-4 for IL-4Ralpha binding and did not interfere with the downstream STAT-6 phosphorylation in T cells.
IL-4Ralpha deficiency inhibited the activation of STAT6 in the mouse kidneys in two experimental models of renal fibrosis. . In vitro, IL-4 activated STAT6 and stimulated expression of alpha-smooth muscle actin and fibronectin in mouse bone marrow monocytes.
IL-13 is able to signal independent of the IL-4Ra chain in AD(atopic dermatitis), which may lead to the identification of molecular pathways downstream of IL-13 signaling that could be targeted in future therapies for AD.
the IL-4/IL-13 Heteroreceptor and its cytokines IL-4 and IL-13 play a role in Th17 to Th1 conversion as well as the differential sensitivity of the effectors to Treg suppression, leading to control of experimental allergic encephalomyelitis
findings indicate that NOD mice lacking the IL-4Ralpha/IL-13Ralpha1 heteroreceptor (HR) display resistance to Type 1 Diabetes as the rise in blood glucose level and islet inflammation were significantly delayed in these HR-deficient relative to HR-sufficient mice
Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r, synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r = interleukin-4 receptor)
increased expression of IL-4Ralpha on neonatal CD11b(+) mDCs was responsible for Th2 - biased RSV immunopathophysiology
these data demonstrate that type 2 IL-4R signaling can directly impair neutrophil recruitment during infection and inflammation
IL-4Ralpha mediated signaling has two opposing functions during experimental schistosomiasis depending on the stage of advancement of the disease; interrupting IL-4Ralpha mediated signaling might be a viable therapeutic strategy to ameliorate liver fibroproliferative pathology in diseases like chronic schistosomiasis
a severe asthma-associated polymorphism in the gene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conversion of induced Treg (iTreg) cells toward a T helper 17 (TH17) cell fate. This skewing is mediated by the recruitment by IL-4Ralpha(R576) of the growth-factor-receptor-bound protein 2 (GRB2) adaptor protein, which drives IL-17 expression by activating a pathway that involves ERK, IL-6 an...
using mice deficient for IL-4Ralpha, findings show after repeated schistosome infection, levels of regulatory IL-10 in the skin were reduced, accompanied by increased numbers of MHC-IIhigh cells and CD4+ T cells in the skin; study highlights a mechanism through which IL-4Ralpha may regulate the immune system through the induction of IL-10 and regulation of Fas/FasL mediated cell death
Together, this study demonstrates that sustained IL-4Ralpha mediated signaling is required for the maintenance of anti-nematode type 2 immune responses, describing a novel function for IL-4Ralpha that is distinct from its role in immune polarization.
this study shows that IL-33R and IL-4Ralpha promote macrophage proliferation independently of each other, but both are essential for induction of alternative activation
IL-4Ralpha expression on CD4+ T cells plays a major role in the pathogenesis of chronic asthma and the regulation of allergen-specific TH17 responses, whereas acute asthmatic pathology and TH2 responses developed in the absence of IL-4Ralpha-responsive CD4+ T cells and IL-4.
Genome-wide expression of isolated Kupffer cells following pressure-controlled hemorrhage revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5, which might represent new biomarkers for early diagnosis of post-traumatic complications.
Il4ra mRNA expression was significantly increased after stroke.
functional synergy between Flt3 and IL-4R signaling is critical for Stat-mediated regulation of sterile gamma1 germ-line transcripts and CSR to IgG1
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
interleukin 4 receptor alpha chain
, interleukin-4 receptor alpha chain
, interleukin-4 receptor subunit alpha
, interleukin 4 receptor
, IL-4RA-like protein 1
, interleukin 4 receptor alpha
, soluble IL-4 receptor alpha
, interleukin-4 receptor subunit alpha-like
, IL-4 receptor subunit alpha
, IL4R nirs variant 1
, IL-4R subunit alpha
, interleukin 4 receptor, alpha
, interleukin 4 tv3
, interleukin 4 tv5
, interleukin-4 receptor alpha-chain
, IL-4 receptor alpha chain