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Human IL4 Receptor Protein expressed in Human Cells - ABIN2002785
Grabstein, Eisenman, Mochizuki, Shanebeck, Conlon, Hopp, March, Gillis: Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines. in The Journal of experimental medicine 1986
Show all 6 Pubmed References
IL-4 (show IL4 Proteins) may play a role in coordinating the adrenal response to inflammatory stress.
IL-4R plays an important role in regulating hepatocellular carcinoma (HCC (show FAM126A Proteins))cell survival and metastasis, and regulates the activity of the JAK1 (show JAK1 Proteins)/STAT6 (show STAT6 Proteins) and JNK (show MAPK8 Proteins)/ERK1/2 signaling pathways. We therefore suggest that IL-4 (show IL4 Proteins)/IL-4R may be a new therapeutic target for HCC (show FAM126A Proteins)
IL4RA and ADAM33 (show ADAM33 Proteins) variants may be risk markers of asthma exacerbations in type-2 inflammatory endotype. Precise endotyping may facilitate the identification of genetic risk markers of asthma exacerbations.
Here in this review, we discuss the structural details of IL-4 (show IL4 Proteins) and IL-4Ralpha subunit and the structural similarities between IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins). We also describe detailed chemistry of type-I and type-II receptor complexes and their signaling pathways. Furthermore, we elaborate the strength of type-II hetero dimer signals in response to IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins).
Naive CD4+ Tconv cells from subjects with asthma bearing the IL4RR576 mutation show defective induction of iTreg cells and their skewing toward a TH17-like phenotype.
Result showed that exposure of Peripheral Blood-Mesenchymal Stem Cells (PB-MSCs) to Noggin was associated with changes in pattern of CD29/CD184 expression. The expression profile of CD29(+/-)/CD184(-) can be suggested as a robust signature for tracing differentiation of PB-MSCs into neuronal cells.
The promoter methylation levels of GATA3 (show GATA3 Proteins), IL-4 (show IL4 Proteins), and TGF-beta (show TGFB1 Proteins) were significantly higher in active VKH patients than in healthy individuals
results suggest that certain polymorphisms of IL4 (show IL4 Proteins) and IL4R may affect susceptibility to gastrointestinal cancer [meta-analysis]
Study indicates that endogenously expressed IL-4 (show IL4 Proteins) and IL-4Ralpha contribute to the malignant phenotype of pancreatic cancer cells by activating diverse pro-oncogenic signaling pathways.
Polymorphisms in promoter region of IL-4 (show IL4 Proteins) but not IL-4RA genes confer susceptibility to juvenile idiopathic arthritis and may predispose individuals to adaptive immune responses.
The aim of this study was to evaluate the impact of the polymorphisms within interleukin 4 (show IL4 Proteins) (rs2243250, rs2227284), interleukin 4 receptor alpha chain (rs1805010, rs1805011) and interleukin 13 (show IL13 Proteins) (rs20541) genes on the incidence of allergic phenotype in Polish pediatric population.
IL4R plays a role in some cases of recurrent airway obstruction.
IL-4Delta2 did not compete with IL-4 (show IL4 Proteins) for IL-4Ralpha binding and did not interfere with the downstream STAT-6 (show STAT6 Proteins) phosphorylation in T cells.
IL-4Ralpha deficiency inhibited the activation of STAT6 (show STAT6 Proteins) in the mouse kidneys in two experimental models of renal fibrosis. . In vitro, IL-4 (show IL4 Proteins) activated STAT6 (show STAT6 Proteins) and stimulated expression of alpha-smooth muscle actin (show ACTG2 Proteins) and fibronectin (show FN1 Proteins) in mouse bone marrow monocytes.
IL-13 (show IL13 Proteins) is able to signal independent of the IL-4Ra chain in AD(atopic dermatitis), which may lead to the identification of molecular pathways downstream of IL-13 (show IL13 Proteins) signaling that could be targeted in future therapies for AD.
the IL-4 (show IL4 Proteins)/IL-13 (show IL13 Proteins) Heteroreceptor and its cytokines IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins) play a role in Th17 to Th1 (show HAND1 Proteins) conversion as well as the differential sensitivity of the effectors to Treg suppression, leading to control of experimental allergic encephalomyelitis
Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 (show GAB2 Proteins) is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 (show GAB2 Proteins) are recruited to Il4r, synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 (show GAB2 Proteins) = growth factor receptor bound protein 2-associated protein 2 (show GAB2 Proteins); Il4r = interleukin-4 receptor)
increased expression of IL-4Ralpha on neonatal CD11b (show ITGAM Proteins)(+) mDCs was responsible for Th2 - biased RSV immunopathophysiology
a severe asthma-associated polymorphism in the gene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conversion of induced Treg (iTreg) cells toward a T helper 17 (TH17) cell fate. This skewing is mediated by the recruitment by IL-4Ralpha(R576) of the growth-factor-receptor-bound protein 2 (GRB2 (show GRB2 Proteins)) adaptor protein, which drives IL-17 (show IL17A Proteins) expression by activating a pathway that involves ERK (show EPHB2 Proteins), IL-6 (show IL6 Proteins) an...
using mice deficient for IL-4Ralpha, findings show after repeated schistosome infection, levels of regulatory IL-10 (show IL10 Proteins) in the skin were reduced, accompanied by increased numbers of MHC-IIhigh cells and CD4 (show CD4 Proteins)+ T cells in the skin; study highlights a mechanism through which IL-4Ralpha may regulate the immune system through the induction of IL-10 (show IL10 Proteins) and regulation of Fas (show FAS Proteins)/FasL (show FASL Proteins) mediated cell death
IL-4Ralpha expression on CD4 (show CD4 Proteins)+ T cells plays a major role in the pathogenesis of chronic asthma and the regulation of allergen-specific TH17 responses, whereas acute asthmatic pathology and TH2 responses developed in the absence of IL-4Ralpha-responsive CD4 (show CD4 Proteins)+ T cells and IL-4 (show IL4 Proteins).
Genome-wide expression of isolated Kupffer cells following pressure-controlled hemorrhage revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5, which might represent new biomarkers for early diagnosis of post-traumatic complications.
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
interleukin 4 receptor alpha chain
, interleukin-4 receptor alpha chain
, interleukin-4 receptor subunit alpha
, interleukin 4 receptor
, IL-4RA-like protein 1
, interleukin 4 receptor alpha
, soluble IL-4 receptor alpha
, interleukin-4 receptor subunit alpha-like
, IL-4 receptor subunit alpha
, IL4R nirs variant 1
, IL-4R subunit alpha
, interleukin 4 receptor, alpha
, interleukin 4 tv3
, interleukin 4 tv5
, interleukin-4 receptor alpha-chain
, IL-4 receptor alpha chain