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the soluble IL-7R represents the dominant transcript in the lung tissue after M. tuberculosis infection.
We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.
The CD4+CD25+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.
Combined mutations in IL-7Ralpha and NRas appear sufficient to drive T cell acute lymphoblastic leukemia formation.
Memory formation and long-term maintenance of memory type I innate lymphoid cells via a lymph node-liver axis is mediated via IL-7Ralpha expression.
IL-7 receptor (IL-7R) is not strictly required for the development of any innate lymphoid cells subset.
the results indicate that endogenous IL-7R signals promote Th1 and Tc1 responses and IFN-gamma- and TNF-alpha production to sustain the persistence of SS-like sialadenitis in NOD mice. These findings suggest that IL-7 and Th1 cytokines could serve as promising therapeutic targets for this prevalent autoimmune disease.
this study demonstrates a key role for IL-7R in the generation of microenvironments required for thymic dendritic cells
show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Ralpha and the induction of transcription factor Sall3
results demonstrated that forced expression of IL-7R not only improved the functionality of tolerized CD8 T cells, it also acted in synergy with PDL-1 deficiency to further promote CD8 T cell cytotoxicity to self antigens
IL-7/IL-7R signaling pathway plays a possible role in recurrent pregnancy loss by upregulating Th17 immunity while downregulating Treg immunity.
this study shows that short-term blockade of IL-7Ralpha induces detectable changes in co-inhibitory receptor expression and Treg frequencies in peripheral blood of NOD mice
results indicate that the induction of IL-7Ralpha expression on dendritic cells (DCs) is critical for thymic stromal lymphopoietin responsiveness and that IL-4 can upregulate IL-7Ralpha on DCs.
IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver
These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP can replace IL-7 in providing these signals.
Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a axis.
results suggest that LNK suppresses IL-7R/JAK/STAT signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations.
The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin resistance in mice.
IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice.
This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs.
Data show the contribution of IL-23/IL-23 receptor and IL-7/IL-7 receptor signaling in Th17 and Th1 cell dynamics during experimental autoimmune encephalomyelitis (EAE).
Inhibition of the IL-7 receptor inhibits tumor growth in murine models of melanoma.
The combined loss of Gads and CD127 reveals a novel function of Gads prior to T cell receptor beta expression
High IL7R expression is associated with pediatric B-cell precursor acute lymphoblastic leukemia.
our results demonstrate that the IL7Ralpha gene variants, rs6897932 and rs201084372, are functionally relevant to susceptibility or protection for multiple sclerosis.
High IL7R expression is associated with lung cancer.
children with type 1 diabetes carrying the protective rs6897932T or risk haplotype rs1494555G had lower serum sIL-7R concentrations as compared to the reference haplotype
Data suggest interleukin 2 receptor subunit alpha (CD25(+))interleukin-7 receptor subunit alpha (CD127(hi)) cells are a highly active subset of memory T cells that might play a role in controlling inflammation via anti-inflammatory Th2-type deviation.
Up-regulation of inflammation-related long noncoding RNA-IL7R predicts poor clinical outcome in patients with cervical cancer.
This study suggests an impact of sIL-7Ralpha levels and rs6897932 donor genotype on alloreactivity and outcome after HSCT. Donor carriage of the rs6897932 T allele was associated with reduced sIL-7Ralpha levels and increased risk of grades II-IV aGVHD.
The IL-7Ralpha rs6897932 genotype of the donor is predictive of acute GVHD and chronic GVHD, CMV infection, and mortality following hematopoietic stem cell transplantation .
IL7R promoter polymorphisms are significantly associated with the age of onset of multiple sclerosis in Turkish population.
Alterations of the IL-7/IL-7R axis and in the levels of inflammatory cytokines were linked to impaired T. cruzi-specific IFN-gamma production.
These data indicate that IL-7Ralpha is involved in breast cancer (BC), and that IL7RA polymorphism may play distinct roles in breast carcinogenesis according to BC subtype, pointing this genetic variant as an interesting marker for breast carcinogenesis to be validated by further mechanistic and prospective studies with larger samples.
Antagonistic interleukin 7 receptor alpha chain (anti-IL-7Ralpha mAbs) induces a long-term control of skin inflammation despite repeated antigen challenges in presensitized monkeys. Long-term in vivo hyporesponsiveness is associated with a decrease of antigen-specific T cells producing IFN-gamma upon antigen restimulation ex vivo.
No significant association between the IL7RA C/T (rs6897932) and IL12B A1188C (rs3212227) gene polymorphisms and multiple sclerosis susceptibility was observed
Increased signal transduction and proliferation in response to IL-7 was found in 'TT' compared to 'CC' IL7RA homozygous HIV-infected individuals providing a mechanistic explanation of the effect of rs6897932 T-allele on CD4+ T cell recovery in HIV infection.
EZH2 mutations coexisted with mutations of NOTCH1, IL7R, and PHF6 in the two Adult T-cell Acute Lymphoblastic Leukemia patients, and they responded poorly to chemotherapy and experienced difficult clinical histories and inferior outcomes
apicidin induced the acetylation of Forkhead box-containing protein, O subfamily 1, which acts as a repressor at the IL7R promoter, accompanied with depleted active histone modifications based on chromatin immunoprecipitation assay. Taken together, these results demonstrated that targeting oncogenic IL7R in ESCC by HDAC inhibitors may be a valuable therapeutic approach.
In all, IL7RA locus polymorphisms could play an important role in the predisposition to multiple sclerosis, which could contribute to a better understanding the pathogenesis of multiple sclerosis.
The results confirm the association between IL7RA exon 6 sequence polymorphisms and increased susceptibility to multiple sclerosis.
The IL7RA rs6897932 polymorphism seems to be related to increased risk of liver fibrosis progression in HCV-infected patients. Thus, the rs6897932 polymorphism could be related to the physiopathology of chronic hepatitis C(CHC) and might be used to successfully stratify the risk of CHC progression.
indicate that IL7RhighSH2B3low expression distinguishes a novel subset of high-risk B-acute lymphoblastic leukemia associated with Ikaros dysfunction
Data show a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden.
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
interleukin 7 receptor
, interleukin-7 receptor subunit alpha-like
, IL-7 receptor alpha chain
, IL-7 receptor subunit alpha
, IL-7R subunit alpha
, interleukin 7 receptor alpha chain
, interleukin-7 receptor subunit alpha
, CD127 antigen
, interleukin 7 receptor isoform H5-6
, Interleukin-7 receptor subunit alpha-like protein
, Interleukin-7 receptor subunit alpha