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We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.
The CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.
IL-7 (show IL7 Proteins) receptor (IL-7R) is not strictly required for the development of any innate lymphoid cells subset.
the results indicate that endogenous IL-7R signals promote Th1 (show HAND1 Proteins) and Tc1 (show C8orf4 Proteins) responses and IFN-gamma (show IFNG Proteins)- and TNF-alpha (show TNF Proteins) production to sustain the persistence of SS-like sialadenitis in NOD mice. These findings suggest that IL-7 (show IL7 Proteins) and Th1 (show HAND1 Proteins) cytokines could serve as promising therapeutic targets for this prevalent autoimmune disease.
show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Ralpha and the induction of transcription factor Sall3
results demonstrated that forced expression of IL-7R not only improved the functionality of tolerized CD8 (show CD8A Proteins) T cells, it also acted in synergy with PDL-1 (show CD274 Proteins) deficiency to further promote CD8 (show CD8A Proteins) T cell cytotoxicity to self antigens
IL-7 (show IL7 Proteins)/IL-7R signaling pathway plays a possible role in recurrent pregnancy loss by upregulating Th17 immunity while downregulating Treg immunity.
this study shows that short-term blockade of IL-7Ralpha induces detectable changes in co-inhibitory receptor expression and Treg frequencies in peripheral blood of NOD mice
results indicate that the induction of IL-7Ralpha expression on dendritic cells (DCs) is critical for thymic stromal lymphopoietin (show TSLP Proteins) responsiveness and that IL-4 (show IL4 Proteins) can upregulate IL-7Ralpha on DCs.
IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver
These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (show TSLP Proteins) can replace IL-7 (show IL7 Proteins) in providing these signals.
Bcl6 (show BCL6 Proteins) promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (show STAT5A Proteins) axis.
Increased signal transduction and proliferation in response to IL-7 (show IL7 Proteins) was found in 'TT' compared to 'CC' IL7RA homozygous HIV-infected individuals providing a mechanistic explanation of the effect of rs6897932 T-allele on CD4 (show CD4 Proteins)+ T cell recovery in HIV infection.
EZH2 (show EZH2 Proteins) mutations coexisted with mutations of NOTCH1 (show NOTCH1 Proteins), IL7R, and PHF6 (show PHF6 Proteins) in the two Adult T-cell Acute Lymphoblastic Leukemia patients, and they responded poorly to chemotherapy and experienced difficult clinical histories and inferior outcomes
apicidin induced the acetylation of Forkhead box-containing protein, O subfamily 1, which acts as a repressor at the IL7R promoter, accompanied with depleted active histone modifications based on chromatin immunoprecipitation assay. Taken together, these results demonstrated that targeting oncogenic IL7R in ESCC by HDAC (show HDAC3 Proteins) inhibitors may be a valuable therapeutic approach.
In all, IL7RA locus polymorphisms could play an important role in the predisposition to multiple sclerosis, which could contribute to a better understanding the pathogenesis of multiple sclerosis.
The results confirm the association between IL7RA exon 6 sequence polymorphisms and increased susceptibility to multiple sclerosis.
The IL7RA rs6897932 polymorphism seems to be related to increased risk of liver fibrosis progression in HCV-infected patients. Thus, the rs6897932 polymorphism could be related to the physiopathology of chronic hepatitis C(CHC) and might be used to successfully stratify the risk of CHC progression.
indicate that IL7RhighSH2B3low expression distinguishes a novel subset of high-risk B-acute lymphoblastic leukemia associated with Ikaros (show IKZF1 Proteins) dysfunction
CD127 is a useful surface marker to isolate donor-antigen-specific-Tregs in operational tolerance after liver transplantation
Data demonstrate that IL-7R expression is regulated by HBX via NF-kappaB (show NFKB1 Proteins) and Notch1 (show NOTCH1 Proteins) pathways to facilitate the activation of intracellular pathways and expression of associated molecules, and contribute to proliferation and migration of hepatoma cells.
We show that heterozygous IL7R exon deletions are common in T-B+NK+ SCID (show PRKDC Proteins) and are detectable by WES. They should be considered if Sanger sequencing fails to detect homozygous or compound heterozygous IL7R SNVs or INDELs.
Data show a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden.
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
interleukin 7 receptor
, interleukin-7 receptor subunit alpha-like
, IL-7 receptor alpha chain
, IL-7 receptor subunit alpha
, IL-7R subunit alpha
, interleukin 7 receptor alpha chain
, interleukin-7 receptor subunit alpha
, CD127 antigen
, interleukin 7 receptor isoform H5-6
, Interleukin-7 receptor subunit alpha-like protein
, Interleukin-7 receptor subunit alpha