IL7R Protein (Fc Tag)
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- Target See all IL7R Proteins
- IL7R (Interleukin 7 Receptor (IL7R))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL7R protein is labelled with Fc Tag.
- Sequence
- Glu21-Gly236
- Purity
- > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human IL-7 at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Human IL-7R alpha, hFc Tag with the EC50 of 0.21μg/ml determined by ELISA. See testing image for detail.
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Interleukin 7 Receptor (IL7R) (AA 21-239) protein (Fc Tag)
IL7R Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 7 Receptor (IL7R) protein (His tag)IL7R Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Interleukin 7 Receptor (IL7R) (AA 21-236) (Active) protein (Fc Tag)IL7R Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 7 Receptor (IL7R) (Active) protein (Fc Tag)IL7R Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 7 Receptor (IL7R) (AA 1-459) protein (GST tag)IL7R Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 7 Receptor (IL7R) (Active) protein (Fc Tag)IL7R Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 7 Receptor (IL7R) protein (His tag)IL7R Origin: Mouse Host: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE
Interleukin 7 Receptor (IL7R) (AA 21-239) protein (His tag)Crystallography grade IL7R Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interleukin 7 Receptor (IL7R) (AA 265-459) protein (His tag)Crystallography grade IL7R Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interleukin 7 Receptor (IL7R) (AA 21-239) protein (His tag)Crystallography grade IL7R Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- IL7R (Interleukin 7 Receptor (IL7R))
- Alternative Name
- IL-7R alpha (IL7R Products)
- Synonyms
- IL7R Protein, CD127 Protein, IL-7Ralpha Protein, CDW127 Protein, IL-7R-alpha Protein, IL7RA Protein, ILRA Protein, IL-7RA Protein, interleukin 7 receptor Protein, IL7R Protein, Il7r Protein
- Background
- IL-17R alpha, IL7Ra, CD127, CDW127, ILRA,Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth.
- Molecular Weight
- 51.6 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.
- Pathways
- JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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