Protein Summary

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Alternative names and synonyms associated with JAK1

• Janus kinase 1 (JAK1) antibody
• Janus kinase 1 (Jak1) antibody
• Janus kinase 1 (jak1) antibody
• tyrosine-protein kinase JAK1 (LOC100286690) antibody

• AA960307 antibody
• C130039L05Rik antibody
• jak1 antibody
• JAK1A antibody
• JAK1B antibody
• Show all synonym aliases
• JTK3 antibody
• wu:fb93e10 antibody

Protein level used designations for Janus Kinase 1 Proteins (JAK1)

tyrosine-protein kinase JAK1 , JAK-1 , etID309794.6 , fb93e10 , jak-1 , jak1 kinase , Janus protein tyrosine kinase 1 , Janus kinase 1 (a protein tyrosine kinase) , tyrosine kinase JAK1 , protein tyrosine kinase , Janus kinase 1 , Tyrosine-protein kinase Jak1 , tyrosine-protein kinase JAK1-like