We are preparing the requested document. Please wait, this may take a while...!
There was a problem generating the requested document, please try again.
JAK3 Antigen Profile
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Alternative names and synonyms associated with JAK3