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anti-Mouse (Murine) Leptin Antibodies:
anti-Human Leptin Antibodies:
anti-Rat (Rattus) Leptin Antibodies:
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Mouse (Murine) Polyclonal Leptin Primary Antibody for ELISA, WB - ABIN3043294
Cheng, Dai, Dai: Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cvarepsilon and is attenuated by an endothelin receptor antagonist CPU0213. in Reproductive toxicology (Elmsford, N.Y.) 2010
Show all 3 Pubmed References
Cow (Bovine) Polyclonal Leptin Primary Antibody for IF (p), IHC (p) - ABIN668243
Chu, Zhao, Feng, Zhang, Liu, Cheng, Li, Shen, Cao, Li, Min: MicroRNA-126 participates in lipid metabolism in mammary epithelial cells. in Molecular and cellular endocrinology 2017
Show all 2 Pubmed References
Human Monoclonal Leptin Primary Antibody for ELISA, IF - ABIN1996123
Sun, Park, Gupta, Holland, Auerbach, Zhang, Goncalves Marangoni, Nicoloro, Czech, Varga, Ploug, An, Scherer: Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. in Nature communications 2014
Human Polyclonal Leptin Primary Antibody for IHC (p), ELISA - ABIN2475317
Paracchini, Pedotti, Taioli: Genetics of leptin and obesity: a HuGE review. in American journal of epidemiology 2005
Cow (Bovine) Polyclonal Leptin Primary Antibody for IHC, WB - ABIN2776943
Müller, Kowalewski, Reichler, Kollár, Balogh: Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs. in Reproduction in domestic animals = Zuchthygiene 2017
Taken together, these results suggest that leptin, in concert with other stimuli in the micro milieu, may contribute to the development of psoriasis.
Thus, Mc4r (show MC4R Antibodies) in the PVH appears to be required for early-life programming of hypertension arising from either maternal obesity or neonatal hyperleptinemia. Early-life exposure of the PVH to maternal obesity through postnatal elevation of leptin may have long-term consequences for cardiovascular health.
t the cellular level, leptin promoted effector T-cell responses and facilitated the presentation of self-antigens to T cells, whereas it inhibited the activity of regulatory CD4 (show CD4 Antibodies) T cells. The understanding of the role of leptin in modulating autoimmune responses in SLE can open possibilities of leptin-targeted therapeutic intervention in the disease.
plasma adiponectin and leptin were also decreased in IL 10tm.These findings suggest that frailty observed in this mouse model of chronic inflammation may in part be driven by alterations in fat mass, hormone secretion and energy metabolism
in congenitally leptin deficient animals, leptin is not required for compensatory reduction in energy expenditure accompanying weight loss, but suggest that the hyperphagia of the weight-reduced state is leptin-dependent.
Our data provide evidence that the interplay of these two hormones could help improve the understanding of the pathogenesis of atherosclerosis and NAFLD (show TSC2 Antibodies).
Data suggest that Htr2c (show HTR2C Antibodies) and leptin in hypothalamic nuclei may be involved in the effects of corticosterone on food intake/appetite regulation. (Htr2c (show HTR2C Antibodies) = 5-hydroxytryptamine type 2C receptor)
Further experiments indicated that miR (show MLXIP Antibodies)-122 inhibited leptin-induced liver fibrosis in leptin-deficient mouse model.
Endoplasmic reticulum stress-induced CHOP (show DDIT3 Antibodies) activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin and IGF1 (show IGF1 Antibodies).
neuronal Rap1 (show TERF2IP Antibodies) critically regulates leptin sensitivity
alterations in leptin and SCD-1 (show SCD Antibodies) in HCU patients
leptin may have a role in androgenetic alopecia in men
study is the first to describe the mechanism of leptin-promoted lymphangiogenesis by upregulating VEGF-C (show VEGFC Antibodies) expression in chondrosarcomas.
The study suggested that leptin accelerated the epithelial mesenchymal transition of A549cells through inhibiting autophagy via PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway.
Studied adiponectin (ADIPOQ), leptin (LEP), leptin receptor (LEPR (show LEPR Antibodies)), and resistin (RETN (show RETN Antibodies)) single nucleotide polymorphisms and their association in obesity. Results showed that ADIPOQ 4522CLEP 2548GRETN (show RETN Antibodies) 420C
Mendelian randomization study estimating the causal effect of leptin on Alzheimer disease (AD) did not find an effect of genetically predicted circulating leptin and sOB-R levels on AD. As such, this study suggests that leptin is unlikely to be a major contributor to AD, although the wide confidence intervals preclude a definitive assessment.
Leptin levels were not altered in dementia.
Leptin, and leptin receptor (show LEPR Antibodies) polymorphisms and breast cancer risk in a Chinese cohort of women.
Obesity was associated with higher expression of NILCO molecules (Notch (show NOTCH1 Antibodies)-IL1 (show IL1A Antibodies)-leptin) in type II endometrial cancer.
SLL (show SLC35B2 Antibodies) might be beneficial as a useful biomarker in preclinical setting of NSCLC to guide detecting the lung cancer subtypes as well as monitoring the patients
study has allowed a transcriptional characterization of LEP and LEPR (show LEPR Antibodies) isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.
A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.
The presence of leptin and ObR (show LEPR Antibodies)-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
Studied 3'UTR (show UTS2R Antibodies) leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR (show LEPR Antibodies) in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR (show LEPR Antibodies) complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb (show LEPR Antibodies) mRNA in porcine endometrium was mainly negative-regulated by leptin
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance
Leptin and leptin receptor (show LEPR Antibodies) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.
Consistent with this, leptin enhanced GnRH (show GNRH1 Antibodies)-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2 (show CA2 Antibodies)+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.
The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.
A leptin SNP (LEPg.978) was significantly associated with a weight at one year.
The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.
Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (show NPY Antibodies) and insulin (show INS Antibodies) signaling pathways.
Leptin R25C genotype impacted most traits associated with fatness.
The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (show NPY Antibodies)) release.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR (show LEPR Antibodies)/T945M affected significantly calving interval (P<0.01) only
polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production
study suggests that increased CSF (show CSF2 Antibodies) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (show IGF1 Antibodies) after traumatic brain injury, leads to accelerated fracture healing
We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (show GHRL Antibodies).
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (show PPARG Antibodies) and CD36 (show CD36 Antibodies) mRNA expression in hypercholesterolemic rabbits.
Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.
Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.
Plasma levels of leptin (as well as glucose, insulin, and growth hormone) are highly correlated with the duration of winter anovulatory phase.
GHRL (show GHRL Antibodies), LEP, ADIP (show SSX2IP Antibodies), INS (show INS Antibodies) and CORT (show CORT Antibodies) concentrations were measured using radioimmunoassay
positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares
The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin (show RETN Antibodies) in a set of four chair-restraint habituated intact adult male rhesus monkeys.
results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
, leptin (murine obesity homolog)
, leptin (obesity homolog, mouse)
, obese protein
, obese, mouse, homolog of