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Leptin antibody (AA 8-37)

LEP Reactivity: Human FACS, IF, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031600
$578.58
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  • Target See all Leptin (LEP) Antibodies
    Leptin (LEP)
    Binding Specificity
    • 13
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 8-37
    Reactivity
    • 24
    • 13
    • 11
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 37
    • 4
    • 2
    Rabbit
    Clonality
    • 37
    • 5
    Polyclonal
    Conjugate
    • 26
    • 10
    • 5
    • 2
    This Leptin antibody is un-conjugated
    Application
    • 31
    • 19
    • 17
    • 7
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Cross-Reactivity (Details)
    Expected species reactivity: Mouse
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 8-37 from the human protein was used as the immunogen for this LEP antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the LEP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the LEP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    Leptin (LEP)
    Alternative Name
    Leptin (LEP Products)
    Synonyms
    ob antibody, obese antibody, LEPD antibody, OB antibody, OBS antibody, leptin antibody, Lep antibody, LEP antibody, lep antibody
    Background
    This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq].
    UniProt
    P41159
    Pathways
    JAK-STAT Signaling, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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