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anti-Mouse (Murine) Serotonin Receptor 4 Antibodies:
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Bat Polyclonal Serotonin Receptor 4 Primary Antibody for IHC (p) - ABIN271228
Fang, Liu, Wang, Gao, Hu, Wang, Cook, Needleman, Mikami, Xia, Fei, Hicks, Wood: Neurogastroenterology of tegaserod (HTF 919) in the submucosal division of the guinea-pig and human enteric nervous system. in Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2008
Show all 3 Pubmed References
Study shows that in the murine gastrointestinal tract, activation of 5-HT4 receptors with prucalopride enhances cholinergic contractions, illustrating facilitation of myenteric cholinergic neurotransmission.
These data suggest that correlated expression of Slc6a4 (show SLC6A4 Antibodies) and Htr4 likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (show GUSB Antibodies).
altered 5-HT4R expression may affect the development of cortical glutamatergic control of the dorsal raphe nucleus.
Results demonstrate that the absence of 5-HT4 receptors triggers adaptive changes that could maintain emotional states, and that the behavioural and molecular effects of fluoxetine under pathological depression appear to be critically dependent on 5-HT4 receptors.
HTR4's role in pulmonary function likely relates to neural innervation and control of breathing.
5-HT4 receptor regulating insulin (show INS Antibodies) secretion and acting as a potential drug target in diabetes treatment
The findings of altered lung function and increased AHR (show AHR Antibodies) in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies.
Our in vivo data using pharmacologic and genetic approaches suggest that 5-HT(4) receptors are not involved in the bronchial hyperresponsiveness to 5-HT (show DDC Antibodies) in cigarette smoke-exposed mice
5-HT (show DDC Antibodies) system in the small intestine may play a critical role in regulating circadian rhythms through 5-HT3 (show HTR3A Antibodies)/5-HT4-receptor activation.
These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis.
The 5-HT4 receptor seem to be particularly involved in antigen-induced airway hyperresponsiveness(AI-AHR (show AHR Antibodies)) to ACh (show FGFR3 Antibodies) in guinea-pigs.
Overexpression of G-protein-coupled receptor (show GPBAR1 Antibodies) HTR4 in rod cells affects the glycosylation pattern of coexisting native rhodopsin (show RHO Antibodies).
analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
found that testosterone, but not estradiol, correlated negatively with global 5-HT4R levels suggesting that men with high levels of testosterone have higher cerebral serotonergic tonus.
l-Lysine significantly reduced the surge of plasma aldosterone induced by metoclopramide indicating that l-Lysine is able to efficiently antagonize the adrenal 5-HT4 receptors in vivo.
Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1 (show TRPV1 Antibodies)) agonist capsaicin promotes secondary peristalsis.Esophageal infusion with capsaicin-containing red pepper sauce suspension does create greater mechanosensitivity as measured by secondary peristalsis than 5-HT4 receptor agonist mosapride
Findings replicate our previous observation of a negative association between 5-HT (show DDC Antibodies) 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT (show DDC Antibodies) 4R binding, as a biomarker for synaptic 5-HT (show DDC Antibodies) levels, to the mnestic processing of positive and neutral word stimuli in healthy humans
Results of this study indicated that HTR4 signaling upregulated ERbeta (show ESR2 Antibodies) expression in hormone-naive prostate cancer and could impact on biological processes in hormone-naive prostate cancer.
Data suggest that the 5-HT4 receptor is involved in the neurobiological mechanism underlying familial risk for depression, and that lower striatal 5-HT4 receptor binding is associated with increased risk for developing major depression disorder
PDE3A1 and PDE4D3 are integrated into complexes that contain the 5-HT4(b) receptor and may thereby regulate 5-HT4(b) receptor-mediated signaling.
This study demonistrated that 5-hydroxytryptamine (serotonin) receptor 4 regulate memory.
ADAM19 (show Adam19 Antibodies) rs1422795 and HTR4 rs11168048 are associated with pulmonary function.
neurogenic excitatory and inhibitory motor responses and role of 5-HT(4) receptors in circular smooth muscle
The identification of nine novel COOH-terminal splice variants of the porcine 5-HT(4) receptor, is reported.
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
, 5-hydroxytryptamine receptor 4
, serotonin receptor 4
, serotonin 5-HT4 receptor
, cardiac 5-HT4 receptor
, 5 hydroxytryptamine ( serotonin) receptor 4
, 5-HT4 receptor (two splicing variants L and S)
, serotonin 4A receptor (5-HT4A)