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found that testosterone, but not estradiol, correlated negatively with global 5-HT4R levels suggesting that men with high levels of testosterone have higher cerebral serotonergic tonus.
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l-Lysine significantly reduced the surge of plasma aldosterone induced by metoclopramide indicating that l-Lysine is able to efficiently antagonize the adrenal 5-HT4 receptors in vivo.
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Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis.Esophageal infusion with capsaicin-containing red pepper sauce suspension does create greater mechanosensitivity as measured by secondary peristalsis than 5-HT4 receptor agonist mosapride
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Findings replicate our previous observation of a negative association between 5-HT 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT 4R binding, as a biomarker for synaptic 5-HT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans
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Results of this study indicated that HTR4 signaling upregulated ERbeta expression in hormone-naive prostate cancer and could impact on biological processes in hormone-naive prostate cancer.
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Data suggest that the 5-HT4 receptor is involved in the neurobiological mechanism underlying familial risk for depression, and that lower striatal 5-HT4 receptor binding is associated with increased risk for developing major depression disorder
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PDE3A1 and PDE4D3 are integrated into complexes that contain the 5-HT4(b) receptor and may thereby regulate 5-HT4(b) receptor-mediated signaling.
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The findings of altered lung function and increased AHR in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies.
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This study demonistrated that 5-hydroxytryptamine (serotonin) receptor 4 regulate memory.
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ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function.
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This is the first transgenic model to study human 5-HTreceptor in the atrium ex vivo or in vivo.
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Stimulation of central 5-HT4 receptors is potentially disease-modifying in a transgenic mouse model of Alzheimer's disease.
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Taken together, these data suggest a role for HTR4 in lung development, which may at least in part explain the genetic association with lung function.
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Our results suggest that HTR4 polymorphisms may not play a major role in the susceptibility for suicidal behavior in subjects with schizophrenia.
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These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis.
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Results suggest an important role for the CHRNA5/3 region as a genetic risk factor for airflow obstruction independent of smoking and implicate the HTR4 gene in the etiology of airflow obstruction.
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Our findings are consistent with a model wherein the 5-HTTLPR S allele is associated with relatively increased serotonin levels.
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These findings suggest that the 5-HT(4)R is critically involved in reward circuits that regulate people's food intake
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Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists.
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staining pattern of serotonin receptors in ovary indicates functional role in ovarian physiology. In ovarian tumours, expression is in harmony with a tumour suppressor role in ovarian carcinogenesis, which is supported by observations in the literature
