Browse our anti-Serotonin Receptor 4 (HTR4) Antibodies

Mouse (Murine) Serotonin Receptor 4 (HTR4) interaction partners

1. Impeding serotonergic signaling preferentially gates spike-timing-dependent long-term depression (t-LTD) at thalamostriatal synapses. This t-LTD requires dampened activity of the 5-HT4 receptor subtype.

2. Gut microbiota-produced Tryptamine activates epithelial 5-HT4R serotonin receptor to increase cAMP level and drive colonic fluid secretion.

3. Prefrontal cortex 5-HT4Rs mediate hypophagia following stress.

4. Knock down serotonin receptors 5-HTR3 and 5-HTR4 in neonatal cardiomyocytes resulted in significant increase of cell damage in response to hypoxia, and also led to alternation in heart beating.

5. Study shows that in the murine gastrointestinal tract, activation of 5-HT4 receptors with prucalopride enhances cholinergic contractions, illustrating facilitation of myenteric cholinergic neurotransmission.

6. These data suggest that correlated expression of Slc6a4 and Htr4 likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut.

7. altered 5-HT4R expression may affect the development of cortical glutamatergic control of the dorsal raphe nucleus.

8. Results demonstrate that the absence of 5-HT4 receptors triggers adaptive changes that could maintain emotional states, and that the behavioural and molecular effects of fluoxetine under pathological depression appear to be critically dependent on 5-HT4 receptors.

9. HTR4's role in pulmonary function likely relates to neural innervation and control of breathing.

10. 5-HT4 receptor regulating insulin secretion and acting as a potential drug target in diabetes treatment

11. Its activation facilitates neurogenesis of injured enteric neurons.(review)

12. The findings of altered lung function and increased AHR in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies.

13. Our in vivo data using pharmacologic and genetic approaches suggest that 5-HT(4) receptors are not involved in the bronchial hyperresponsiveness to 5-HT in cigarette smoke-exposed mice

14. 5-HT system in the small intestine may play a critical role in regulating circadian rhythms through 5-HT3/5-HT4-receptor activation.

15. A highly conserved motif in the ligand-binding pocket of serotonin receptors is an important participant in ligand binding.

16. These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis.

17. Endogenous 5-HT exerts a dual role in the pathogenesis of indomethacin-induced intestinal lesions: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors.

18. This review presented that the 5HT4 RECEPTOR knockout mice show a correlation between 5-HT firing rate and depressive/resilience phenotypes.

19. These results show that prenatal stress and reduced 5-HT levels can alter 5-HT(4)R expression in the developing forebrain and that some 5-HT(4)R splice variants.

20. This study demonistrated that alternatively spliced multiple transcripts of 5-hydroxytryptamine receptor expression in heart.

Guinea Pig Serotonin Receptor 4 (HTR4) interaction partners

1. The 5-HT4 receptor seem to be particularly involved in antigen-induced airway hyperresponsiveness(AI-AHR) to ACh in guinea-pigs.

Cow (Bovine) Serotonin Receptor 4 (HTR4) interaction partners

1. Overexpression of G-protein-coupled receptor HTR4 in rod cells affects the glycosylation pattern of coexisting native rhodopsin.

2. analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR

Human Serotonin Receptor 4 (HTR4) interaction partners

1. found that testosterone, but not estradiol, correlated negatively with global 5-HT4R levels suggesting that men with high levels of testosterone have higher cerebral serotonergic tonus.

2. l-Lysine significantly reduced the surge of plasma aldosterone induced by metoclopramide indicating that l-Lysine is able to efficiently antagonize the adrenal 5-HT4 receptors in vivo.

3. Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis.Esophageal infusion with capsaicin-containing red pepper sauce suspension does create greater mechanosensitivity as measured by secondary peristalsis than 5-HT4 receptor agonist mosapride

4. Findings replicate our previous observation of a negative association between 5-HT 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT 4R binding, as a biomarker for synaptic 5-HT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans

5. Results of this study indicated that HTR4 signaling upregulated ERbeta expression in hormone-naive prostate cancer and could impact on biological processes in hormone-naive prostate cancer.

6. Data suggest that the 5-HT4 receptor is involved in the neurobiological mechanism underlying familial risk for depression, and that lower striatal 5-HT4 receptor binding is associated with increased risk for developing major depression disorder

7. PDE3A1 and PDE4D3 are integrated into complexes that contain the 5-HT4(b) receptor and may thereby regulate 5-HT4(b) receptor-mediated signaling.

8. The findings of altered lung function and increased AHR in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies.

9. This study demonistrated that 5-hydroxytryptamine (serotonin) receptor 4 regulate memory.

10. ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function.

11. This is the first transgenic model to study human 5-HTreceptor in the atrium ex vivo or in vivo.

12. Stimulation of central 5-HT4 receptors is potentially disease-modifying in a transgenic mouse model of Alzheimer's disease.

13. Taken together, these data suggest a role for HTR4 in lung development, which may at least in part explain the genetic association with lung function.

14. Our results suggest that HTR4 polymorphisms may not play a major role in the susceptibility for suicidal behavior in subjects with schizophrenia.

15. These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis.

16. Results suggest an important role for the CHRNA5/3 region as a genetic risk factor for airflow obstruction independent of smoking and implicate the HTR4 gene in the etiology of airflow obstruction.

17. Our findings are consistent with a model wherein the 5-HTTLPR S allele is associated with relatively increased serotonin levels.

18. These findings suggest that the 5-HT(4)R is critically involved in reward circuits that regulate people's food intake

19. Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists.

20. staining pattern of serotonin receptors in ovary indicates functional role in ovarian physiology. In ovarian tumours, expression is in harmony with a tumour suppressor role in ovarian carcinogenesis, which is supported by observations in the literature

Pig (Porcine) Serotonin Receptor 4 (HTR4) interaction partners

1. neurogenic excitatory and inhibitory motor responses and role of 5-HT(4) receptors in circular smooth muscle

2. The identification of nine novel COOH-terminal splice variants of the porcine 5-HT(4) receptor, is reported.