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Human SOCS2 Protein expressed in Wheat germ - ABIN1320927
Sen, Peng, Woods, Wistuba, Bell, El-Naggar, Lai, Johnson: STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
The upregulation of SOCS-1 (show SOCS1 Proteins) and SOCS-2 by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.
Overexpression of miR (show MLXIP Proteins)-196b suppresses SOCS2 in human laryngeal squamous cell carcinoma resulting in tumor progression and poor prognosis.
Methyltransferase-like 3 (show METTL3 Proteins) represses SOCS2 expression in hepatocellular carcinoma through an m6A (show GPM6A Proteins)-YTHDF2 (show YTHDF2 Proteins)-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis
Study in lung cancer BEAS-2B cells shows that SOCS2 binding to the growth hormone receptor (GHR (show GHR Proteins)) is impaired by a GHR (show GHR Proteins) threonine substitution at Pro 495. This results in decreased internalisation and degradation of the receptor.
SOCS-1 (show SOCS1 Proteins), SOCS-2, and SOCS-3 (show SOCS3 Proteins) proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer
Despite of the key role of SOCS2 in the regulation of GH receptor (show GHR Proteins) signaling, study did not find any significant association between SOCS2 polymorphisms and acromegaly.
The induction of a tolerogenic phenotype in DCs by NPs (show NPS Proteins) was mediated by the AhR (show AHR Proteins)-dependent induction of Socs2, which resulted in inhibition of nuclear factor kappaB activation and proinflammatory cytokine production (properties of tolerogenic DCs).
Long-term palmitate treatment up-regulates SOCS2 and reduces PI3K (show PIK3CA Proteins) activity, thereby impairing glucose stimulated insulin (show INS Proteins) secretion.
Targeting of SOCS2 by miR (show MLXIP Proteins)-194 resulted in derepression of the oncogenic kinases FLT3 (show FLT3 Proteins) and JAK2 (show JAK2 Proteins), leading to enhanced ERK (show EPHB2 Proteins) and STAT3 (show STAT3 Proteins) signaling.
Single-cell RNA sequencing reveals enrichment of homeostatic modules in monocytes and dendritic cells from human metastatic melanoma. Suppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFNgamma.
this study shows that IL-7 (show IL7 Proteins) induces the expression of SOCS2 through the JAK (show JAK3 Proteins)/STAT-5 (show STAT5A Proteins) pathway and that SOCS2 interacts with CD127 (show IL7R Proteins) in early endosomes and direct the receptor complex to the proteasome for degradation
the absence of SOCS2 is protective against bone loss typical of inflammatory bowel disease.
SOCS2 deletion had no effect on total dendrite length, number of dendritic segments, number of branch points or total dendritic spine density but increased the number of mature "mushroom" spines.
Upon deletion of the STAT5 (show STAT5A Proteins) response elements from the Socs2 promoter in mice, cytokine induction was abrogated, while basal activity remained intact. Our data suggest that promoter-bound STAT5 (show STAT5A Proteins) modulates cytokine responses and enhancer-bound STAT5 (show STAT5A Proteins) is mandatory for gene activation.
In a knockout mouse model, deficiency of SOCS2 was associated with decreased neuroinflammation and increased survival following HSV-1 infection, without significant effect on viral load. This result indicates that SOCS2 plays a major role in driving neuroinflammation and subsequent brain damage during HSV-1 encephalitis.
Our data show that absence of SOCS2 turns cardiomyocytes unresponsive to LIF (show LIF Proteins)-induced [Ca(2 (show CA2 Proteins)+)] raise, indicating that endogenous levels of SOCS2 are crucial for full activation of LIF (show LIF Proteins) signaling in the heart.
Knockdown of SOCS2 makes mice less sensitive to multiple low dose streptozotocin.
Study provides an insight into the role of SOCS2 in modulating the immune response to Bovine herpesvirus 5 [BoHV-5]infection.
Data (including data from studies in knockout mice) suggest Socs2 regulates liver regeneration rate after partial hepatectomy, Ghr (growth hormone receptor (show GHR Proteins)) level via ubiquitination/proteolysis, and serum Igf1 (insulin-like growth factor-1 (show IGF1 Proteins)) level.
GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1 (show IGF1 Proteins).
hepatic growth hormone receptor (show GHR Proteins) and suppressor of cytokine signaling (SOCS (show CISH Proteins))2 messenger RNA expression appeared to be promptly and sensitively regulated by increased estradiol levels before ovulation of dairy heifers
relative amount of suppressors of cytokine signaling-2 (SOCS-2)messenger RNA increased after parturition
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
suppressor of cytokine signaling-2
, suppressor of cytokine signaling 2
, suppressor of cytokine signaling 2 variant 1
, STAT induced STAT inhibitor-2
, STAT-induced STAT inhibitor 2
, STAT-induced STAT inhibitor-2
, cytokine-inducible SH2 protein 2
, cytokine inducible SH2-containing protein 2
, suppressor of cytokine signalling 2