Browse our anti-SOCS6 (SOCS6) Antibodies

Full name:: anti-Suppressor of Cytokine Signaling 6 Antibodies (SOCS6)

On www.antibodies-online.com are 54 Suppressor of Cytokine Signaling 6 (SOCS6) Antibodies from 0 different suppliers available. A total of 66 SOCS6 products are currently listed.

Synonyms:: 1500012M23Rik, 5830401B18Rik, AI447482, CIS-4, Cis4, Cish4, HSPC060, MGC81477, SOCS-4, SOCS-6, Socs4, SOCS6, SSI4, STAI4, STATI4

list all antibodies	Gene Name	GeneID	UniProt
Anti-Rat SOCS6	SOCS6	307200
Anti-Human SOCS6	SOCS6	9306	O14544
Anti-Mouse SOCS6	SOCS6	54607	Q9JLY0
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Relevant Pathways for anti-SOCS6 Antibodies

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More Antibodies against SOCS6 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Suppressor of Cytokine Signaling 6 (SOCS6) interaction partners

Four new members of the SOCS (show CISH Antibodies) family of molecules in rainbow trout (Oncorhynchus mykiss), CISH (show CISH Antibodies) and SOCS6, 7 and 9, are described for the first time in this species

Human Suppressor of Cytokine Signaling 6 (SOCS6) interaction partners

Together, our data provide important evidence for miR (show MLXIP Antibodies)-19 mediated SOCS6 in OS growth and revealed miR (show MLXIP Antibodies)-19/SOCS6/JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) pathway as a potential therapeutic strategy for OS patients.
Results indicate that similar to PTEN pseudogene (PTENP1), suppressor of cytokine signaling 6 protein (SOCS6) expression was also significantly lower in esophageal squamous cell carcinoma (ESCC) samples.
our results describe for the first time the role of miR (show MLXIP Antibodies)-494-3p during normal hematopoietic stem/progenitor cells differentiation and suggest that its increased expression, and the subsequent downregulation of its target SOCS6, might contribute to the megakaryocyte hyperplasia commonly observed in primary myelofibrosis patients.
miR (show MLXIP Antibodies)-142-3p regulates NPC (show NPC1 Antibodies) development by down-regulating SOCS6 expression and suggest that modulation of miR (show MLXIP Antibodies)-142-3p expression could be a therapeutic strategy for NPC (show NPC1 Antibodies)
Stage-independent downregulation of SOCS2 (show SOCS2 Antibodies) and SOCS6 correlate with disease-free survival in colorectal cancer.
Studied both the function of upregulated miR (show MLXIP Antibodies)-424-5p in pancreatic cancer and how downstream suppressor of cytokine-induced signaling 6 (SOCS6) is negatively regulated by miR (show MLXIP Antibodies)-424-5p.
miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer
SOCS2 (show SOCS2 Antibodies) and SOCS6 expression are remarkably reduced in hepatocellular carcinoma and correlate with aggressive tumor progression and poor prognosis
Results show that SOCS6 forms complex with DRP1 (show CRMP1 Antibodies) and the mitochondrial phosphatase PGAM5 (show PGAM5 Antibodies), attenuates DRP1 (show CRMP1 Antibodies) phosphorylation, and promotes DRP1 (show CRMP1 Antibodies) mitochondrial translocation.
SOCS6 negatively regulates Flt3 (show FLT3 Antibodies) activation, the downstream Erk (show EPHB2 Antibodies) signaling pathway, and cell proliferation.

Mouse (Murine) Suppressor of Cytokine Signaling 6 (SOCS6) interaction partners

Results suggest: 1) SOCS6 and SOCS7 (show SOCS7 Antibodies) bind tyrosine-phosphorylated DAB1 (show DAB1 Antibodies) and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 (show DAB1 Antibodies) by SOCS6 and SOCS7 (show SOCS7 Antibodies) terminates reelin (show RELN Antibodies) signaling and allows a new cycle of reelin (show RELN Antibodies) signaling to commence. 3) Repeated cycles of reelin (show RELN Antibodies) signaling "ON" and "OFF" drive the fundamentally cyclic process of cell migration in the cortex.
Our results show that endogenous Cul5 (show CUL5 Antibodies) suppresses epithelial cell transformation by several pathways, including inhibition of Src (show SRC Antibodies)-Cas (show CTNND1 Antibodies)-induced ruffling through SOCS6
SOCS-6 binds to insulin receptor substrate 4 (show IRS4 Antibodies), and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)
SOCS4 expression, in contrast, does not appear to be EPO (show EPO Antibodies) inducible.SOCS4 is ineffective at counteracting EPO (show EPO Antibodies)-mediated events.
SOCS6 has a role as a negative regulator of receptor tyrosine kinases
SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase
TH1 (show HAND1 Antibodies)-specific chromatin structure is created by early recruitment of Swi (show SMARCA1 Antibodies)-SNF (show SNRPA Antibodies) complexes and nucleosome remodeling dependent on Stat4 (show STAT4 Antibodies).

SOCS6 Antigen Profile

Antigen Summary

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

Alternative names and synonyms associated with SOCS6

suppressor of cytokine signaling 6 (Socs6) antibody
suppressor of cytokine signaling 6 (SOCS6) antibody
suppressor of cytokine signaling 6 L homeolog (socs6.L) antibody
suppressor of cytokine signaling (socs6) antibody
suppressor of cytokine signaling 6 (socs6) antibody

1500012M23Rik antibody
5830401B18Rik antibody
AI447482 antibody
CIS-4 antibody
Cis4 antibody
Cish4 antibody
HSPC060 antibody
MGC81477 antibody
SOCS-4 antibody
SOCS-6 antibody
Socs4 antibody
SOCS6 antibody
SSI4 antibody
STAI4 antibody
STATI4 antibody

Protein level used designations for SOCS6

suppressor of cytokine signaling 6 , suppressor of cytokine signaling , hypothetical protein LOC100124796 , STAT induced STAT inhibitor-4 , cytokine-inducible SH2 protein 4 , suppressor of cytokine signaling 4 , CIS-4 , SH2 domain containing SOCS box protein SOCS6 , cytokine inducible SH2-containing protein 4 , cytokine inducible SH2-containing protein CIS4 , SOCS-6

GENE ID	SPECIES
307200	Rattus norvegicus
421020	Gallus gallus
446567	Xenopus laevis
455521	Pan troglodytes
476171	Canis lupus familiaris
615146	Bos taurus
704108	Macaca mulatta
778986	Ciona intestinalis
100015445	Monodelphis domestica
100052089	Equus caballus
100124796	Xenopus (Silurana) tropicalis
100144310	Takifugu rubripes
100144377	Oryzias latipes
100155619	Sus scrofa
100344911	Oryctolagus cuniculus
100474949	Ailuropoda melanoleuca
100499596	Oncorhynchus mykiss
100526650	Bombyx mori
9306	Homo sapiens
54607	Mus musculus
100172146	Pongo abelii

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