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Browse our anti-SOCS6 (SOCS6) Antibodies

Full name:: anti-Suppressor of Cytokine Signaling 6 Antibodies (SOCS6)

On www.antibodies-online.com are 59 Suppressor of Cytokine Signaling 6 (SOCS6) Antibodies from 18 different suppliers available. Additionally we are shipping SOCS6 Proteins (3) and SOCS6 Kits (1) and many more products for this protein. A total of 68 SOCS6 products are currently listed.

Synonyms:: 1500012M23Rik, 5830401B18Rik, AI447482, CIS-4, Cis4, Cish4, HSPC060, MGC81477, SOCS-4, SOCS-6, Socs4, SOCS6, socs6l, SSI4, STAI4, STATI4, wu:fb77f06, zgc:64107

list all antibodies	Gene Name	GeneID	UniProt
	SOCS6	9306	O14544
	SOCS6	307200
	SOCS6	54607	Q9JLY0
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Human Suppressor of Cytokine Signaling 6 (SOCS6) interaction partners

Low SOCS6 expression is associated with Prostate Cancer.
Together, our data provide important evidence for miR-19 mediated SOCS6 in OS growth and revealed miR-19/SOCS6/JAK2/STAT3 pathway as a potential therapeutic strategy for OS patients.
Results indicate that similar to PTEN pseudogene (PTENP1), suppressor of cytokine signaling 6 protein (SOCS6) expression was also significantly lower in esophageal squamous cell carcinoma (ESCC) samples.
our results describe for the first time the role of miR-494-3p during normal hematopoietic stem/progenitor cells differentiation and suggest that its increased expression, and the subsequent downregulation of its target SOCS6, might contribute to the megakaryocyte hyperplasia commonly observed in primary myelofibrosis patients.
miR-142-3p regulates NPC development by down-regulating SOCS6 expression and suggest that modulation of miR-142-3p expression could be a therapeutic strategy for NPC
Stage-independent downregulation of SOCS2 and SOCS6 correlate with disease-free survival in colorectal cancer.
Studied both the function of upregulated miR-424-5p in pancreatic cancer and how downstream suppressor of cytokine-induced signaling 6 (SOCS6) is negatively regulated by miR-424-5p.
miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer
SOCS2 and SOCS6 expression are remarkably reduced in hepatocellular carcinoma and correlate with aggressive tumor progression and poor prognosis
Results show that SOCS6 forms complex with DRP1 and the mitochondrial phosphatase PGAM5, attenuates DRP1 phosphorylation, and promotes DRP1 mitochondrial translocation.
SOCS6 negatively regulates Flt3 activation, the downstream Erk signaling pathway, and cell proliferation.
Reduced copy number and mRNA expression of SOCS6 are associated with disease recurrence in primary lung squamous cell carcinoma and may be useful prognostic biomarkers.
The results may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.
SOCS6 has ubiquitin ligase activity toward c-KIT
These results establish that SOCS-6 acts as a negative regulator of T cell activation by promoting ubiquitin-dependent proteolysis of p56(lck).
Data support the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis.
HOIL-1 expression stabilizes SOCS6 and induces the ubiquitination and degradation of proteins associated with SOCS6
These observations suggest that Erk activation may be correlated in the cells with high expression of SOCS6.
These observations suggest that SOCS6 is composed of at least two functional domains required for its biological role in localizing and degrading Stat3 in the nucleus.
Study demonstrated that hypermethylation of the SOCS6 promoter is one of the mechanisms for the epigenetic regulation of SOCS6 expression.

Rainbow Trout (Oncorhynchus mykiss) Suppressor of Cytokine Signaling 6 (SOCS6) interaction partners

Four new members of the SOCS family of molecules in rainbow trout (Oncorhynchus mykiss), CISH and SOCS6, 7 and 9, are described for the first time in this species

Mouse (Murine) Suppressor of Cytokine Signaling 6 (SOCS6) interaction partners

Results suggest: 1) SOCS6 and SOCS7 bind tyrosine-phosphorylated DAB1 and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 by SOCS6 and SOCS7 terminates reelin signaling and allows a new cycle of reelin signaling to commence. 3) Repeated cycles of reelin signaling "ON" and "OFF" drive the fundamentally cyclic process of cell migration in the cortex.
Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)
SOCS4 expression, in contrast, does not appear to be EPO inducible.SOCS4 is ineffective at counteracting EPO-mediated events.
SOCS6 has a role as a negative regulator of receptor tyrosine kinases
SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase
TH1-specific chromatin structure is created by early recruitment of Swi-SNF complexes and nucleosome remodeling dependent on Stat4.

SOCS6 Antigen Profile

Antigen Summary

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

Alternative names and synonyms associated with SOCS6

suppressor of cytokine signaling 6 (SOCS6) antibody
suppressor of cytokine signaling 6 (Socs6) antibody
suppressor of cytokine signaling 6 L homeolog (socs6.L) antibody
suppressor of cytokine signaling (socs6) antibody
suppressor of cytokine signaling 6 (socs6) antibody
suppressor of cytokine signaling 6b (socs6b) antibody

1500012M23Rik antibody
5830401B18Rik antibody
AI447482 antibody
CIS-4 antibody
Cis4 antibody
Cish4 antibody
HSPC060 antibody
MGC81477 antibody
SOCS-4 antibody
SOCS-6 antibody
Socs4 antibody
SOCS6 antibody
socs6l antibody
SSI4 antibody
STAI4 antibody
STATI4 antibody
wu:fb77f06 antibody
zgc:64107 antibody

Protein level used designations for SOCS6

STAT induced STAT inhibitor-4 , cytokine-inducible SH2 protein 4 , suppressor of cytokine signaling 4 , suppressor of cytokine signaling 6 , suppressor of cytokine signaling , hypothetical protein LOC100124796 , SOCS-6 , CIS-4 , SH2 domain containing SOCS box protein SOCS6 , cytokine inducible SH2-containing protein 4 , cytokine inducible SH2-containing protein CIS4 , suppressor of cytokine signaling 6 protein , suppressor of cytokine signaling 6, like

GENE ID	SPECIES
9306	Homo sapiens
307200	Rattus norvegicus
421020	Gallus gallus
446567	Xenopus laevis
455521	Pan troglodytes
476171	Canis lupus familiaris
615146	Bos taurus
704108	Macaca mulatta
778986	Ciona intestinalis
100015445	Monodelphis domestica
100052089	Equus caballus
100124796	Xenopus (Silurana) tropicalis
100144310	Takifugu rubripes
100144377	Oryzias latipes
100155619	Sus scrofa
100172146	Pongo abelii
100344911	Oryctolagus cuniculus
100474949	Ailuropoda melanoleuca
100499596	Oncorhynchus mykiss
54607	Mus musculus
322950	Danio rerio
100526650	Bombyx mori

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