SOCS6 antibody (AA 1-210)

Catalog No. ABIN7171008

Product Details anti-SOCS6 Antibody

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Binding Specificity: AA 1-210

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 6 protein (1-210AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SOCS6

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Alternative Name: SOCS6 (SOCS6 Products)

Synonyms: CIS-4 antibody, CIS4 antibody, HSPC060 antibody, SOCS-4 antibody, SOCS-6 antibody, SOCS4 antibody, SSI4 antibody, STAI4 antibody, STATI4 antibody, socs6 antibody, MGC81477 antibody, SOCS6 antibody, 1500012M23Rik antibody, 5830401B18Rik antibody, AI447482 antibody, Cis4 antibody, Cish4 antibody, Socs4 antibody, socs6l antibody, zgc:64107 antibody, wu:fb77f06 antibody, suppressor of cytokine signaling 6 antibody, suppressor of cytokine signaling 6 L homeolog antibody, suppressor of cytokine signaling antibody, suppressor of cytokine signaling 6b antibody, SOCS6 antibody, Socs6 antibody, socs6.L antibody, socs6 antibody, socs6b antibody

Background:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Aliases: CIS-4 antibody, CIS4 antibody, Cish4 antibody, Cytokine inducible SH2 protein 4 antibody, Cytokine-inducible SH2 protein 4 antibody, HSPC060 antibody, SOCS-4 antibody, SOCS-6 antibody, SOCS4 antibody, Socs6 antibody, SOCS6_HUMAN antibody, SSI4 antibody, STAI4 antibody, STAT induced STAT inhibitor 4 antibody, STAT4 antibody, STATI4 antibody, Suppressor of cytokine signaling 4 antibody, Suppressor of cytokine signaling 6 antibody

UniProt: O14544

Pathways: JAK-STAT Signaling, Carbohydrate Homeostasis