Thymic Stromal Lymphopoietin ELISA Kit
Quick Overview for Thymic Stromal Lymphopoietin ELISA Kit (ABIN4987141)
Target
See all Thymic Stromal Lymphopoietin (TSLP) ELISA KitsReactivity
Detection Method
Method Type
Detection Range
Application
Sample Type
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Minimum Detection Limit
- 3.9 pg/mL
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Analytical Method
- Quantitative
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Specificity
- Natural and recombinant Human TSLP Ligand
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Sensitivity
- 2 pg/mL
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Material not included
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- Microplate reader.
- Pipettes and pipette tips.
- EP tube Deionized or distilled water.
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Application Notes
- Detection Wavelength: 450 nm
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Sample Volume
- 20 μL
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Assay Time
- 3 h
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Plate
- Pre-coated
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Restrictions
- For Research Use only
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Storage
- 4 °C
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- Thymic Stromal Lymphopoietin (TSLP)
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Alternative Name
- TSLP
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Background
- Thymic Stromal Lymphopoietin (TSLP) is a 23 kDa member of the IL-7 family of a-helical cytokines (1-3). It is a monomeric glycoprotein that is synthesized as a 159 amino acid (aa) precursor (4, 5). TSLP appears to have species-specific functions. In mouse, TSLP was initially reported to act on NK cells, mast cells, and B cells, but this does not appear to occur in humans. In humans, TSLP is produced by a number of divergent cell types, all of which appear to target T cells, monocytes, and/or dendritic cells (2). On TCR-activated T cells, TSLP directly induces T cell proliferation (6). The significance of this direct action is unclear. On monocytes, TSLP is reported to induce the release of multiple chemokines that target CCR4, a receptor associated with the Th2 subset (5). TSLP is best known for its direct action on subsets of dendritic cells. In thymic medulla, Hassell
Target See all Thymic Stromal Lymphopoietin (TSLP) ELISA Kits
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