EDIL3 ELISA Kit

Catalog No. ABIN5510665

This Colorimetric ELISA kit is designed for the quantitative measurement of Human EDIL3.

Quick Overview for EDIL3 ELISA Kit (ABIN5510665)

Target: EDIL3 (DEL1) (EGF like repeats and discoidin domains 3 (DEL1))

Binding Specificity: AA 24-480

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details EDIL3 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human EDIL3

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: D24-E480

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for EDIL3

Target: EDIL3 (DEL1) (EGF like repeats and discoidin domains 3 (DEL1))

Alternative Name: EDIL3

Background:

Protein Function: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.

Background: EDIL3, also known as DEL1, is a glycoprotein that is secreted by endothelial cells and can associate with the endothelial cell surface and the extracellular matrix. It is regulated by hypoxia or vascular injury and has been implicated in vascular remodeling during angiogenesis. The EDIL3 gene is mapped to 5q14. Human endothelial cells bind to Del1 together with the alpha-V (ITGAV)/beta-3 (ITGB3) integrin receptor. It is confirmed that adhesion of endothelial cells to Del1 is integrin mediated and that Del1 binds ITGAV/ITGB3. Functional analysis showed that both Del1 and vitronectin (VTN) stimulate endothelial cell migration. Immunoprecipitation and immunoblot analyses revealed that adhesion of endothelial cells to Del1 induces tyrosine phosphorylation of PTK2.

Synonyms: EGF-like repeat and discoidin I-like domain-containing protein 3,Developmentally-regulated endothelial cell locus 1 protein,Integrin-binding protein DEL1,EDIL3,DEL1,

Full Gene Name: EGF-like repeat and discoidin I-like domain-containing protein 3

Cellular Localisation: Secreted.

UniProt: O43854