GREM2 ELISA Kit

Catalog No. ABIN5510700

Rabbit GREM2 ELISA Kit Colorimetric assay for quantification of Rabbit GREM2.

Quick Overview for GREM2 ELISA Kit (ABIN5510700)

Target: GREM2 (Gremlin 2 (GREM2))

Binding Specificity: AA 22-168

Reactivity: Rabbit

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details GREM2 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of rabbit GREM2

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: E.coli
Immunogen sequence: R22-Q168

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for GREM2

Target: GREM2 (Gremlin 2 (GREM2))

Alternative Name: GREM2

Background:

Protein Function: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells (By similarity). .

Background: GREM2, also known as PRDC, is one of several BMP antagonists that regulate the functions of BMPs during embryonic development and tissue differentiation. BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. The PRDC gene is mapped to chromosome 1q43.

Synonyms: Gremlin-2,Cysteine knot superfamily 1, BMP antagonist 2,DAN domain family member 3,Protein related to DAN and cerberus,GREM2,CKTSF1B2, DAND3, PRDC,

Full Gene Name: Gremlin-2

Cellular Localisation: Secreted.

UniProt: Q9H772