PVRL4 ELISA Kit

Catalog No. ABIN5510701

This Colorimetric ELISA kit is designed for the quantitative measurement of Human PVRL4.

Quick Overview for PVRL4 ELISA Kit (ABIN5510701)

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Binding Specificity: AA 32-349

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details PVRL4 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Nectin-4

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: G32-S349

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. .

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for PVRL4

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Alternative Name: NECTIN4

Background:

Protein Function: Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

Background: Nectin-4, also known as PVRL4, is an adhesion receptor of the immunoglobulin superfamily and functions in cell-cell adhesion. This gene is mapped to chromosome 1q23.3. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Synonyms: Nectin-4,Ig superfamily receptor LNIR,Nectin cell adhesion molecule 4 ,Poliovirus receptor-related protein 4,Processed poliovirus receptor-related protein 4,NECTIN4 ,LNIR, PRR4, PVRL4,

Full Gene Name: Nectin-4

Cellular Localisation: Cell membrane, Single-pass type I membrane protein . Cell junction, adherens junction . Colocalizes with MLLT4 at cadherin-based adherens junctions (PubMed:11544254).

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization