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Human Polyclonal alpha 2 Macroglobulin Primary Antibody for IHC - ABIN965492
Matthijs, Devriendt, Cassiman, Van den Berghe, Marynen: Structure of the human alpha-2 macroglobulin gene and its promotor. in Biochemical and biophysical research communications 1992
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Human Polyclonal alpha 2 Macroglobulin Primary Antibody for IHC, IHC (p) - ABIN4279699
Häggmark, Neiman, Drobin, Zwahlen, Uhlén, Nilsson, Schwenk: Classification of protein profiles from antibody microarrays using heat and detergent treatment. in New biotechnology 2012
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Human Polyclonal alpha 2 Macroglobulin Primary Antibody for IF (p), IHC (p) - ABIN1387864
Hu, Lin, Zhu, Li, Chen: Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains. [Corrected]. in Molecular medicine reports 2015
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Human Polyclonal alpha 2 Macroglobulin Primary Antibody for IHC - ABIN965491
Sottrup-Jensen, Stepanik, Kristensen, Wierzbicki, Jones, Lønblad, Magnusson, Petersen: Primary structure of human alpha 2-macroglobulin. V. The complete structure. in The Journal of biological chemistry 1984
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The blood coagulation pathway may be a key regulatory network pathway contributing to the allergic inflammatory response in AR patients. A2M, which is regulated by STAT3 (show STAT3 Antibodies), may be an important protein in the pathogenesis of allergic rhinitis in AR patients.
Proteomics study showed a strong association of FN1 (show FN1 Antibodies), A2M, C4BPA (show C4BPA Antibodies) and CFB (show CFB Antibodies) in molecular subtypes of breast cancer, in which, C4BPA (show C4BPA Antibodies) and A2M demonstrated a potent signature in blood plasma and tissue samples of Luminal-B (LB (show HLA-DPB1 Antibodies)) and Triple-negative (TN)subtypes in BC patients, respectively.
BBB (show ALMS1 Antibodies) disruption is present in ACS (show PLA2G15 Antibodies), and elevated levels of IL-6 (show IL6 Antibodies) and C3 in CSF (show CSF2 Antibodies) in diffuse NPSLE
Case Reports: inflammatory myofibroblastic tumors of the lung containing a chimeric A2M-ALK gene categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants.
The plasma level of alpha2M was found positively correlated, while HCII (show SERPIND1 Antibodies) level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII (show SERPIND1 Antibodies) may be potential biomarkers for evaluation of the vulnerability of carotid ...
Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control.
Data show that low that low globulin (GLB (show DCXR Antibodies)) levels were significantly associated with favorable survival, and low ALB (show ALB Antibodies) levels were associated with a significantly worse survival .
This work demonstrates that alpha2M*/CS-GRP78 (show HSPA5 Antibodies) acts as an upstream regulator of the PDK1 (show PDK1 Antibodies)/PLK1 (show PLK1 Antibodies) signaling axis to modulate c-MYC (show MYC Antibodies) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (show MYC Antibodies)-associated malignant progression.
Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease.
These data demonstrate that alpha2M* and LRP1 (show LRP1 Antibodies) modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2 (show CA2 Antibodies)+)dynamics in hMSMCs during pregnancy.
To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs (show SLC26A4 Antibodies)) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice
A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (show HAMP Antibodies) remains labile and available to down-regulate Fpn1 (show SLC40A1 Antibodies).
Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase.
MMP9 (show MMP9 Antibodies) production promoted by the alpha(2)M*/LRP1 (show LRP1 Antibodies) interaction required the activation of both MAPK (show MAPK1 Antibodies)-ERK1/2 and NF-kappaB (show NFKB1 Antibodies) signaling pathways.
Alpha2 macroglobulin requires cyclic amp (show TMPRSS5 Antibodies) and signal transduction for cell growth
Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.
the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents
Data describe the role of the PI3-kinase (show PIK3CA Antibodies)/PDK (show PDK2 Antibodies)/Akt (show AKT1 Antibodies)/p70s6k (show RPS6KB1 Antibodies) signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB (show CREB1 Antibodies) in these events.
review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy.
the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind
Data suggest that alpha(2)-macroglobulin from serum could significantly compensate for the impaired cumulus expansion of oocytes matured in serum.
Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows.
We report here for the first time the direct isolation of Spp24 (show SPP2 Antibodies) covalently bound to alpha2-macroglobulins as a core complex (Spp24 (show SPP2 Antibodies)-alpha2M) from bovine calf serum.
Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis.
These results suggest the possible involvement of cathepsin E (show CTSE Antibodies) in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.
Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 (show ADAMTS4 Antibodies) and ADAMTS-5 (show ADAMTS5 Antibodies)
Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles.
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
, alpha 2m
, alpha-2-macroglobulin b
, pregnancy zone protein