EDG-1
S1PR1
WB
Whole Cell Lysate
Catalog No. ABIN924989
Quick Overview for EDG-1 (ABIN924989)
Target
S1PR1
(Sphingosine-1-Phosphate Receptor 1 (S1PR1))
Application
Western Blotting (WB)
Lysate Fraction
Whole Cell Lysate
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Application Notes
- Western blotting: Use 10 µl per lane as a control for EDG-1 polyclonal antibody (ABIN187786)
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Cell lysate provided in 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-mercaptoethanol.
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Storage
- -20 °C
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- S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
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Alternative Name
- EDG-1
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Background
- EDG-1 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-1 is sphingosine-1- phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-1 is expressed in cardiovascular, leukocyte containing and other tissues. Use: For use as a positive control with the EDG-1 polyclonal antibody (PC-085) for Western blot analysis.
Target
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