Browse our Dynein, Light Chain, LC8-Type 1 Proteins (DYNLL1)

Human Dynein, Light Chain, LC8-Type 1 (DYNLL1) interaction partners

1. DYNLL1 binds directly to MRE11 to limit its end-resection activity; it is inferred that DYNLL1 is an important anti-resection factor that influences genomic stability and responses to DNA-damaging chemotherapy

2. It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains.

3. High PIN expression is associated with Dilated Hearts.

4. An expanded list of LC8 binding partners revealed the evolutionary plasticity of binding partners despite the highly conserved binding interface. In addition, it also highlighted a novel, conserved function of LC8 in the upstream regulation of the Hippo signaling pathway.

5. DLC1 binding to nNOS-calmodulin complex does not affect the electron transport from the reductase to the oxygenase domain.

6. NMR-derived secondary chemical shifts and relaxation properties show that the Chica LC8 binding domain is essentially disordered with a dynamically restricted segment in one linker between motifs.

7. Studies indicate that dynein light chain LC8 has been termed an intrinsically disordered proteins (IDPs) dimerization 'hub' protein.

8. DLC1 binding motif in L is involved in cytoskeleton localization and reorganization, primary transcription regulation by DLC1, and regulation of cellular DLC1 gene expression.

9. The dynein light intermediate chain has a Ras-like fold with insertions that distinguish it from Ras and other previously described G proteins.

10. Authors demonstrate that the interaction between ebola virus VP35 and dynein LC8 is direct and of high affinity and that binding stabilizes the VP35 N-terminal oligomerization domain and enhances viral RNA synthesis.

11. Overall, this study demonstrates the novel interaction between HIV-1 integrase and cellular DYNLL1 proteins and suggests the requirement of this virus-cell interaction for proper uncoating and efficient reverse transcription of HIV-1.

12. Structural analysis of LC8 with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 upon phosphorylation on Ser(944) within the Nek9 sequence

13. Dynein forms distinct complexes requiring specific recruiters and activators to promote orderly progression through mitosis.

14. Overexpressed human LC8 inhibits mouse osteoclast differentiation by regulating NF-kappaB & MAPK pathways and suppressing RANKL signaling.

15. DYNLL1 interacted with a spindle-microtubule-associated adaptor formed by CHICA and HMMR via TQT motifs in CHICA.

16. appropriate levels of ternary complex components are critical for dynein-dependent spindle positioning in HeLa cells and C. elegans embryos

17. Cytosolic mfGbeta is recruited to dynein by Nudel and transported to the centrosome for rapid sequestration and degradation.

18. Study found the secretion of calu-1/2-EGFP required microtubule integrity, and that calu-1/2-EGFP-containing vesicles were transported by the motor proteins Kif5b and cytoplasmic dynein.

19. The ASCIZ-DYNLL1 feedback loop represents a novel mechanism for auto-regulation of gene expression, where the gene product directly inhibits the transcriptional activator while bound at its own promoter.

20. The study uses thermodynamics and dynamics measurements of LC8 complexes to group LC8 binding partners in two categories: those whose binding is enthalpically driven and those that are entropically favored.

Mouse (Murine) Dynein, Light Chain, LC8-Type 1 (DYNLL1) interaction partners

1. oncogenic MYC expression, which is synthetic lethal with Dynll1 deletion in B-2 cells, did not further reduce B-1a cell numbers in Dynll1-defcient mice. we found that the ASCIZ-DYNLL1 axis was also required for the early-juvenile development of aggressive MYC-driven and p53-deficient B cell lymphomas.

2. ASCIZ and its target DYNLL1 are essential for the development and expansion of MYC-driven B cell lymphoma.

3. These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.

4. a key role for ASCIZ in regulating the survival of developing B cells by activating DYNLL1 expression, which may then modulate Bim-dependent apoptosis

5. The ASCIZ-DYNLL1 feedback loop represents a novel mechanism for auto-regulation of gene expression, where the gene product directly inhibits the transcriptional activator while bound at its own promoter.

6. the regulation of DLC1 by p21-activated kinase 1 is a novel mechanism by which a signaling kinase might influence macropinocytosis

7. PIN/LC8 is associated with cytosolic but not membrane-bound nNOS in the nitrergic varicosities of mice gut.

8. Our studies suggest an unexpected role for LC8 and provide new mechanistic insights into how SNPH and LC8 together immobilize mitochondria through a dynamic interaction between the docking receptor and axonal cytoskeleton.

Cow (Bovine) Dynein, Light Chain, LC8-Type 1 (DYNLL1) interaction partners

1. LC8 promotes assembly and stabilization of microtubules.

2. By yeast two-hybrid assay, the authors found that the capsid protein (CA) of bovine immunodeficiency virus interacted with the dynein light-chain component LC8.

Pig (Porcine) Dynein, Light Chain, LC8-Type 1 (DYNLL1) interaction partners

1. DYNLL1, mediated porcine circovirus type 2 intracellular trafficking.

2. Large dynein heads take 16-nm steps by using an overlapping hand-over-hand mechanism.

Caenorhabditis elegans (C. elegans) Dynein, Light Chain, LC8-Type 1 (DYNLL1) interaction partners

1. Data suggest that dynein light chain 1 (DLC-1) acts as a cofactor for multiple ribonucleoprotein complexes, including the ones regulating gene expression during oogenesis.

2. DLC-1 binding to GLD-1 prevents ectopic germ cell proliferation and facilitates gametogenesis in vivo.

3. DLC-1 directly binds to FBF-2 outside of the RNA-binding domain and promotes FBF-2 localization and function. This result identifies a new role for DLC-1 in post-transcriptional regulation of gene expression.

4. DLC-1 is functioning cell nonautonomously through the same pathway as kri-1 in response to ionizing radiation-induced apoptosis.

5. Dynein light chain 1 (DLC-1) and its partner, dynein heavy chain 1, inhibit the proliferative cell fate, in part through regulation of METT-10, a conserved putative methyltransferase.