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The data suggest that GCP6 is a target of Plk4 (show PLK4 Antibodies) in centriole biogenesis.
Study identified sequence variants in the known disease-causing genes SLC6A3 (show SLC6A3 Antibodies) and FLVCR1 (show FLVCR1 Antibodies), and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1 (show C7orf27 Antibodies), SNIP1 (show SNIP1 Antibodies), CRADD (show CRADD Antibodies), and HARS (show HARS Antibodies).
GCP6 participates in the attachment of microtubule-organizing centers to intermediate filaments in epithelial cells and is among the factors that determine the peculiar architecture of microtubules in polarized epithelia.
The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome.
gamma-tubulin complex component 6
, tubulin, gamma complex associated protein 6
, gamma tubulin ring protein
, Gamma-tubulin complex component 6-like
, gamma-tubulin complex component 6-like