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The data suggest that GCP6 is a target of Plk4 in centriole biogenesis.
Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS.
GCP6 participates in the attachment of microtubule-organizing centers to intermediate filaments in epithelial cells and is among the factors that determine the peculiar architecture of microtubules in polarized epithelia.
The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome.
gamma-tubulin complex component 6
, tubulin, gamma complex associated protein 6
, gamma tubulin ring protein
, Gamma-tubulin complex component 6-like
, gamma-tubulin complex component 6-like