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MAP3K4 antibody (AA 1-100)

MAP3K4 Reactivity: Human IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7268654
  • Target See all MAP3K4 Antibodies
    MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
    Binding Specificity
    • 15
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-100
    Reactivity
    • 50
    • 8
    • 5
    Human
    Host
    • 47
    • 3
    Rabbit
    Clonality
    • 46
    • 4
    Polyclonal
    Conjugate
    • 20
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAP3K4 antibody is un-conjugated
    Application
    • 31
    • 27
    • 22
    • 13
    • 13
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Purpose
    MAP3K4 Rabbit pAb
    Sequence
    MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ
    Cross-Reactivity
    Human, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP3K4 (NP_005913.2).
    Isotype
    IgG
    Top Product
    Discover our top product MAP3K4 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:100 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
    Alternative Name
    MAP3K4 (MAP3K4 Products)
    Synonyms
    MAPKKK4 antibody, MEKK4 antibody, MTK1 antibody, PRO0412 antibody, D17Rp17 antibody, D17Rp17e antibody, MEKK 4 antibody, Mek4b antibody, Mekk4 antibody, RP17 antibody, Rp17a antibody, Tas antibody, mKIAA0213 antibody, mitogen activated protein kinase kinase kinase 4 antibody, mitogen-activated protein kinase kinase kinase 4 antibody, Map3k4 antibody, MAP3K4 antibody
    Background
    The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.,MAP3K4,MAPKKK4,MEKK 4,MEKK4,MTK1,PRO0412,Signal Transduction,Kinase,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,Neuroscience,MAP3K4
    Molecular Weight
    177kDa/181kDa
    Gene ID
    4216
    UniProt
    Q9Y6R4
    Pathways
    MAPK Signaling
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