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anti-Mouse (Murine) NDC80 Antibodies:
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Human Monoclonal NDC80 Primary Antibody for FACS, ICC - ABIN151804
Chen, Riley, Chen, Lee: HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis. in Molecular and cellular biology 1997
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Human Polyclonal NDC80 Primary Antibody for ELISA, WB - ABIN249648
Schödel, Oikonomopoulos, Ragoussis, Pugh, Ratcliffe, Mole: High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. in Blood 2011
Show all 2 Pubmed References
Human Monoclonal NDC80 Primary Antibody for ELISA, WB - ABIN564521
Scott, Nogueira, Heffernan, van Doorn, Dhakal, Hanna, Min, Jaskelioff, Xiao, Wu, Cameron, Perry, Zeid, Feinberg, Kim, Vande Woude, Granter, Bosenberg, Chu, DePinho, Rimm, Chin: Proinvasion metastasis drivers in early-stage melanoma are oncogenes. in Cancer cell 2011
The results indicate that Sf3A2 and Prp31 directly regulate interactions among kinetochores, spindle microtubules and the Ndc80 complex in both Drosophila and human cells.
kinetochores movement depends on SPC105R, can occur in the absence of NDC80, and is antagonized by plus-end directed forces from the CENP-E motor.
These data strongly indicated that KNTC2 is a promising target for the treatment of HCC and that phosphorylated HH3 at serine 10 is one of the target engagement markers for KNTC2.
Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age
Hec1-dependent cyclin B2 stabilization during early metaphase is important for early-stage spindle assembly.
Disruption of Ndc80 function by either siRNA injection or antibody injection resulted in severe chromosome misalignment, spindle disruption, and precocious polar body extrusion.
overexpression of Hec1 results in mitotic checkpoint hyperactivation that leads to aneuploidy sufficient to generate tumors
nuclear division cycle 80, cyclin B2 and topoisomerase 2alpha may serve important roles in adrenocortical tumor development.
High NDC80 expression is associated with colorectal cancer.
Using pulldown assays with HeLa cell lysates and site-directed mutagenesis, this study shows that HEC1 is a bona fide substrate of the lysine acetyltransferase Tat-interacting protein, 60 kDa (TIP60) and that TIP60-mediated acetylation of HEC1 is essential for accurate chromosome segregation in mitosis.
NDC80 binding is modulated in a chromosome autonomous fashion over prometaphase and metaphase, and is predominantly regulated by centromere tension.
These findings support the idea that dynein may control the function of the Ndc80 complex in stabilizing kinetochore-microtubule attachments directly by interfering with Ndc80-microtubule binding or indirectly by controlling the Rod-mediated inhibition of Ndc80.
Aurora A kinase regulates kinetochore-microtubule dynamics of metaphase chromosomes, and Hec1 S69, a previously uncharacterized phosphorylation target site in the Hec1 tail, is a critical Aurora A substrate for this regulation.
Ska complex directly binds Ndc80 complex through interactions between the Ska3 unstructured C-terminal region and the coiled-coil regions of each Ndc80 complex subunit.
Hec1 tail phosphorylation tunes friction along polymerizing microtubules and yet does not compromise the kinetochore's ability to grip depolymerizing microtubules.
We provided novel evidence that NDC80 expression is upregulated in osteosarcoma tissues, where it is positively correlated with advanced tumor stage and distant metastasis
Ndc80 recruits Bod1 to kinetochores which directly feeds forward to regulate Ndc80
The authors show that the Astrin-SKAP complex binds synergistically to microtubules with the Ndc80 complex to form an integrated interface.
Elevated expression of NDC80 may play a role in promoting the development of hepatocellular carcinoma
Study shows that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core outer kinetochore component, also show that this phosphorylation occurs specifically during mitosis and is required for the kinetochore localization of the Ska complex.
This study suggests that Ndc80 may play an important role in the process of hepatitis B virus-related hepatocellular carcinoma, and that it may be a potential biological treatment target in the future.
Whereas CENP-C recruits a single MIS12:NDC80 complex, the authors show here that CENP-T binds one MIS12:NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1:Cyclin B complex at three distinct CENP-T sites.
Ska is recruited to kinetochores by clusters of Ndc80 proteins.
Expression of NDC80 in colon cancer cells and tissues was higher than that in controls. NDC80 promotes the proliferation and metastasis of colon cancer cells.
Ndc80 complex bound to microtubules binds every tubulin monomer along the microtubule protofilament.
we conclude that Hec1 is consistently overexpressed in human PCa and Hec1 is closely linked with human PCa progression through the meditator LncRNA BX647187
mature attachment via the Ndc80 complex is essential for metaphase alignment and anaphase A
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.
kinetochore associated 2
, NDC80 homolog, kinetochore complex component (S. cerevisiae)
, NDC80 homolog, kinetochore complex component
, kinetochore protein NDC80 homolog
, kinetochore protein Ndc80
, Kinetochore protein NDC80 homolog
, highly expressed in cancer, rich in leucine heptad repeats
, kinetochore protein Hec1
, kinetochore-associated protein 2
, HEC (highly expressed in cancer)
, NDC80 kinetochore complex component homolog
, highly expressed in cancer protein
, retinoblastoma-associated protein HEC
, kinetochore spindle checkpoint protein Ndc80