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Human Monoclonal NDC80 Primary Antibody for FACS, ICC - ABIN151804
Chen, Riley, Chen, Lee: HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis. in Molecular and cellular biology 1997
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Human Polyclonal NDC80 Primary Antibody for ELISA, WB - ABIN249648
Schödel, Oikonomopoulos, Ragoussis, Pugh, Ratcliffe, Mole: High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. in Blood 2011
Show all 2 Pubmed References
Human Monoclonal NDC80 Primary Antibody for ELISA, WB - ABIN564521
Scott, Nogueira, Heffernan, van Doorn, Dhakal, Hanna, Min, Jaskelioff, Xiao, Wu, Cameron, Perry, Zeid, Feinberg, Kim, Vande Woude, Granter, Bosenberg, Chu, DePinho, Rimm, Chin: Proinvasion metastasis drivers in early-stage melanoma are oncogenes. in Cancer cell 2011
kinetochores movement depends on SPC105R, can occur in the absence of NDC80, and is antagonized by plus-end directed forces from the CENP-E (show CENPE Antibodies) motor.
These data strongly indicated that KNTC2 is a promising target for the treatment of HCC (show FAM126A Antibodies) and that phosphorylated HH3 (show PROKR2 Antibodies) at serine 10 is one of the target engagement markers for KNTC2.
Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age
Hec1-dependent cyclin B2 (show CCNB2 Antibodies) stabilization during early metaphase is important for early-stage spindle assembly.
Disruption of Ndc80 function by either siRNA injection or antibody injection resulted in severe chromosome misalignment, spindle disruption, and precocious polar body extrusion.
overexpression of Hec1 results in mitotic checkpoint (show BUB3 Antibodies) hyperactivation that leads to aneuploidy sufficient to generate tumors
We provided novel evidence that NDC80 expression is upregulated in osteosarcoma tissues, where it is positively correlated with advanced tumor stage and distant metastasis
Ndc80 recruits Bod1 (show BOD1 Antibodies) to kinetochores which directly feeds forward to regulate Ndc80
The authors show that the Astrin (show SPAG5 Antibodies)-SKAP (show KNSTRN Antibodies) complex binds synergistically to microtubules with the Ndc80 complex to form an integrated interface.
Elevated expression of NDC80 may play a role in promoting the development of hepatocellular carcinoma
Study shows that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core outer kinetochore component, also show that this phosphorylation occurs specifically during mitosis and is required for the kinetochore localization of the Ska complex.
This study suggests that Ndc80 may play an important role in the process of hepatitis B virus-related hepatocellular carcinoma, and that it may be a potential biological treatment target in the future.
Whereas CENP-C (show CENPC1 Antibodies) recruits a single MIS12 (show MIS12 Antibodies):NDC80 complex, the authors show here that CENP-T (show CENPT Antibodies) binds one MIS12 (show MIS12 Antibodies):NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1 (show CDK1 Antibodies):Cyclin B complex at three distinct CENP-T (show CENPT Antibodies) sites.
Ska is recruited to kinetochores by clusters of Ndc80 proteins.
Expression of NDC80 in colon cancer cells and tissues was higher than that in controls. NDC80 promotes the proliferation and metastasis of colon cancer cells.
Ndc80 complex bound to microtubules binds every tubulin (show TUBB Antibodies) monomer along the microtubule protofilament.
mature attachment via the Ndc80 complex is essential for metaphase alignment and anaphase A
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.
kinetochore associated 2
, NDC80 homolog, kinetochore complex component (S. cerevisiae)
, NDC80 homolog, kinetochore complex component
, kinetochore protein NDC80 homolog
, kinetochore protein Ndc80
, Kinetochore protein NDC80 homolog
, highly expressed in cancer, rich in leucine heptad repeats
, kinetochore protein Hec1
, kinetochore-associated protein 2
, HEC (highly expressed in cancer)
, NDC80 kinetochore complex component homolog
, highly expressed in cancer protein
, retinoblastoma-associated protein HEC
, kinetochore spindle checkpoint protein Ndc80