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different isoforms of Araf may participate in similar developmental processes but by regulating different signaling pathways
The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2 (show STK3 Antibodies), thus rendering cells susceptible to apoptosis
This review discusses the regulation of A-Raf protein (show RAF1 Antibodies) expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf (show RAF1 Antibodies) inhibitors. [review]
analysis of FGFR2 (show FGFR2 Antibodies)-PPHLN1 (show PPHLN1 Antibodies) fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Aberrant expression of A-, B-, and C-RAF (show RAF1 Antibodies), and COT (show MAP3K8 Antibodies) is frequent in PTC (show F9 Antibodies); increased expression of COT (show MAP3K8 Antibodies) is correlated with recurrence of PTC (show F9 Antibodies).
Dimerization of the kinase ARAF promotes MAPK (show MAPK1 Antibodies) pathway activation and cell migration.
The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis.
Galpha12 (show GNA12 Antibodies)-ARAF-ERK (show EPHB2 Antibodies) pathway stimulates RFFL (show RFFL Antibodies) transcription through the transcription factor c-Myc (show MYC Antibodies).
show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 (show SMAD2 Antibodies) signals in vertebrate embryos by directly inhibiting Smad2 (show SMAD2 Antibodies) signalling
study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK (show MAPK1 Antibodies) pathway in cells treated with RAF (show RAF1 Antibodies) inhibitors; ARAF seems to stabilize BRAF:CRAF complexes in cells treated with RAF (show RAF1 Antibodies) inhibitors and regulate cell signaling in a subtle manner to ensure signaling efficiency
Ras pathway activation via EGF (show EGF Antibodies) treatment induced strong binding between B-Raf (show SNRPE Antibodies) and C-Raf (show RAF1 Antibodies) and a low level of binding between B-Raf (show SNRPE Antibodies) and A-Raf.
PKM1 interacts with A-Raf, an upstream regulator of the MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) pathway, and that this interaction contributes to MEK1 (show MAP2K1 Antibodies) phosphorylation by A-Raf.
A- and B-Raf (show SNRPE Antibodies) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf (show RAF1 Antibodies) decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf (show RAF1 Antibodies) does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (show VEGFA Antibodies) protein stability.
A-Raf promotes osteoblasts differentiation in response to mechanical stress.
DA-Raf (show RAF1 Antibodies)-dependent inhibition of the Ras-ERK (show EPHB2 Antibodies) signaling pathway in alveolar epithelial 2 cells is required for alveolar formation via triggering MMP2 (show MMP2 Antibodies) activation followed by myofibroblast differentiation.
Expression of Araf in the mouse nucleus accumbens is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (show UTS2R Antibodies) of Comt (catechol-O-methyltransferase (show COMT Antibodies)).
the binding of 14-3-3gamma (show YWHAG Antibodies) to Raf (show RAF1 Antibodies) indicates the critical role of this protein in ischemia-induced apoptosis and the changes in signal transduction in astrocytes in culture.
Raf-1 (show RAF1 Antibodies) and A-Raf have a combined role in controlling physiological transient ERK (show EPHB2 Antibodies) activation and in maintenance of cell cycle progression at its usual rate.
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
serine/threonine protein kinase ARAF standard form
, serine/threonine-protein kinase A-Raf
, v-raf murine sarcoma 3611 viral oncogene homolog
, v-raf murine sarcoma 3611 viral oncogene-like protein
, serine/threonine protein kinase ARAF
, serine/threonine-protein kinase A-Raf-like
, A-Raf proto-oncogene serine/threonine-protein kinase
, Oncogene ARAF1
, Ras-binding protein DA-Raf
, proto-oncogene A-Raf-1
, proto-oncogene Pks
, v-raf murine sarcoma 3611 viral oncogene homolog 1
, proto-oncogene A-Raf
, raf-related oncogene
, Raf related protein
, Ras-binding protein
, v-raf oncogene homolog 1 (murine sarcoma 3611 virus)