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different isoforms of Araf may participate in similar developmental processes but by regulating different signaling pathways
The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2 (show STK3 Proteins), thus rendering cells susceptible to apoptosis
This review discusses the regulation of A-Raf protein (show RAF1 Proteins) expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf (show RAF1 Proteins) inhibitors. [review]
analysis of FGFR2 (show FGFR2 Proteins)-PPHLN1 (show PPHLN1 Proteins) fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Aberrant expression of A-, B-, and C-RAF (show RAF1 Proteins), and COT (show MAP3K8 Proteins) is frequent in PTC (show F9 Proteins); increased expression of COT (show MAP3K8 Proteins) is correlated with recurrence of PTC (show F9 Proteins).
Dimerization of the kinase ARAF promotes MAPK (show MAPK1 Proteins) pathway activation and cell migration.
The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis.
Galpha12-ARAF-ERK (show EPHB2 Proteins) pathway stimulates RFFL (show RFFL Proteins) transcription through the transcription factor c-Myc (show MYC Proteins).
show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 (show SMAD2 Proteins) signals in vertebrate embryos by directly inhibiting Smad2 (show SMAD2 Proteins) signalling
study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK (show MAPK1 Proteins) pathway in cells treated with RAF (show RAF1 Proteins) inhibitors; ARAF seems to stabilize BRAF:CRAF complexes in cells treated with RAF (show RAF1 Proteins) inhibitors and regulate cell signaling in a subtle manner to ensure signaling efficiency
Ras pathway activation via EGF (show EGF Proteins) treatment induced strong binding between B-Raf (show SNRPE Proteins) and C-Raf (show RAF1 Proteins) and a low level of binding between B-Raf (show SNRPE Proteins) and A-Raf.
A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability.
A-Raf promotes osteoblasts differentiation in response to mechanical stress.
DA-Raf (show RAF1 Proteins)-dependent inhibition of the Ras-ERK (show EPHB2 Proteins) signaling pathway in alveolar epithelial 2 cells is required for alveolar formation via triggering MMP2 (show MMP2 Proteins) activation followed by myofibroblast differentiation.
Expression of Araf in the mouse nucleus accumbens is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase (show COMT Proteins)).
the binding of 14-3-3gamma (show YWHAG Proteins) to Raf (show RAF1 Proteins) indicates the critical role of this protein in ischemia-induced apoptosis and the changes in signal transduction in astrocytes in culture.
Raf-1 (show RAF1 Proteins) and A-Raf have a combined role in controlling physiological transient ERK (show EPHB2 Proteins) activation and in maintenance of cell cycle progression at its usual rate.
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
serine/threonine protein kinase ARAF standard form
, serine/threonine-protein kinase A-Raf
, v-raf murine sarcoma 3611 viral oncogene homolog
, v-raf murine sarcoma 3611 viral oncogene-like protein
, serine/threonine protein kinase ARAF
, serine/threonine-protein kinase A-Raf-like
, A-Raf proto-oncogene serine/threonine-protein kinase
, Oncogene ARAF1
, Ras-binding protein DA-Raf
, proto-oncogene A-Raf-1
, proto-oncogene Pks
, v-raf murine sarcoma 3611 viral oncogene homolog 1
, proto-oncogene A-Raf
, raf-related oncogene
, Raf related protein
, Ras-binding protein
, v-raf oncogene homolog 1 (murine sarcoma 3611 virus)