Browse our ARAF Proteins (ARAF)

Full name:: V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog Proteins (ARAF)

On www.antibodies-online.com are 9 V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Proteins from 5 different suppliers available. Additionally we are shipping ARAF Antibodies (170) and ARAF Kits (4) and many more products for this protein. A total of 193 ARAF products are currently listed.

Synonyms:: 1200013E08Rik, A-Raf, araf, Araf1, AW495444, PKS2, RAFA1, wu:fk45h07, zgc:92074

list all proteins	Gene Name	GeneID	UniProt
	ARAF	369	P10398
	ARAF	11836	P04627
	ARAF	64363	P14056
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Zebrafish V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) interaction partners

different isoforms of Araf may participate in similar developmental processes but by regulating different signaling pathways

Human V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) interaction partners

The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2 (show STK3 Proteins), thus rendering cells susceptible to apoptosis
This review discusses the regulation of A-Raf protein (show RAF1 Proteins) expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf (show RAF1 Proteins) inhibitors. [review]
analysis of FGFR2 (show FGFR2 Proteins)-PPHLN1 (show PPHLN1 Proteins) fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Aberrant expression of A-, B-, and C-RAF (show RAF1 Proteins), and COT (show MAP3K8 Proteins) is frequent in PTC (show F9 Proteins); increased expression of COT (show MAP3K8 Proteins) is correlated with recurrence of PTC (show F9 Proteins).
Dimerization of the kinase ARAF promotes MAPK (show MAPK1 Proteins) pathway activation and cell migration.
The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis.
Galpha12-ARAF-ERK (show EPHB2 Proteins) pathway stimulates RFFL (show RFFL Proteins) transcription through the transcription factor c-Myc (show MYC Proteins).
show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 (show SMAD2 Proteins) signals in vertebrate embryos by directly inhibiting Smad2 (show SMAD2 Proteins) signalling
study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK (show MAPK1 Proteins) pathway in cells treated with RAF (show RAF1 Proteins) inhibitors; ARAF seems to stabilize BRAF:CRAF complexes in cells treated with RAF (show RAF1 Proteins) inhibitors and regulate cell signaling in a subtle manner to ensure signaling efficiency
Ras pathway activation via EGF (show EGF Proteins) treatment induced strong binding between B-Raf (show SNRPE Proteins) and C-Raf (show RAF1 Proteins) and a low level of binding between B-Raf (show SNRPE Proteins) and A-Raf.

Mouse (Murine) V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) interaction partners

PKM1 interacts with A-Raf, an upstream regulator of the MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) pathway, and that this interaction contributes to MEK1 (show MAP2K1 Proteins) phosphorylation by A-Raf.
A- and B-Raf (show SNRPE Proteins) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf (show RAF1 Proteins) decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf (show RAF1 Proteins) does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (show VEGFA Proteins) protein stability.
A-Raf promotes osteoblasts differentiation in response to mechanical stress.
DA-Raf (show RAF1 Proteins)-dependent inhibition of the Ras-ERK (show EPHB2 Proteins) signaling pathway in alveolar epithelial 2 cells is required for alveolar formation via triggering MMP2 (show MMP2 Proteins) activation followed by myofibroblast differentiation.
Galpha12-ARAF-ERK (show EPHB2 Proteins) pathway stimulates RFFL (show RFFL Proteins) transcription through the transcription factor c-Myc (show MYC Proteins).
Expression of Araf in the mouse nucleus accumbens is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase (show COMT Proteins)).
the binding of 14-3-3gamma to Raf (show RAF1 Proteins) indicates the critical role of this protein in ischemia-induced apoptosis and the changes in signal transduction in astrocytes in culture.
Raf-1 (show RAF1 Proteins) and A-Raf have a combined role in controlling physiological transient ERK (show EPHB2 Proteins) activation and in maintenance of cell cycle progression at its usual rate.

ARAF Protein Profile

Protein Summary

This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with ARAF

A-Raf proto-oncogene, serine/threonine kinase (araf)
A-Raf proto-oncogene, serine/threonine kinase (ARAF)
A-Raf proto-oncogene, serine/threonine kinase L homeolog (araf.L)
A-Raf proto-oncogene, serine/threonine kinase S homeolog (araf.S)
Araf proto-oncogene, serine/threonine kinase (Araf)
A-Raf proto-oncogene, serine/threonine kinase (Araf)

1200013E08Rik protein
A-Raf protein
araf protein
Araf1 protein
AW495444 protein
PKS2 protein
RAFA1 protein
wu:fk45h07 protein
zgc:92074 protein

Protein level used designations for ARAF

serine/threonine protein kinase ARAF standard form , serine/threonine-protein kinase A-Raf , v-raf murine sarcoma 3611 viral oncogene homolog , v-raf murine sarcoma 3611 viral oncogene-like protein , serine/threonine protein kinase ARAF , serine/threonine-protein kinase A-Raf-like , A-Raf proto-oncogene serine/threonine-protein kinase , Oncogene ARAF1 , Ras-binding protein DA-Raf , proto-oncogene A-Raf-1 , proto-oncogene Pks , v-raf murine sarcoma 3611 viral oncogene homolog 1 , proto-oncogene A-Raf , raf-related oncogene , Raf related protein , Ras-binding protein , v-raf oncogene homolog 1 (murine sarcoma 3611 virus) , A-Raf-1

GENE ID	SPECIES
403063	Danio rerio
707169	Macaca mulatta
100305131	Ovis aries
100340437	Oryctolagus cuniculus
398892	Xenopus laevis
399056	Xenopus laevis
100387961	Callithrix jacchus
100431871	Pongo abelii
369	Homo sapiens
11836	Mus musculus
64363	Rattus norvegicus
491857	Canis lupus familiaris
397601	Sus scrofa
540421	Bos taurus

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