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High MEK1 expression is associated with liver cancer.
The BRAF/MAP2K1-mut LCH cells had a more immature state than BRAF/MAP2K1-wt LCH cells. Authors also found the BRAFV600E and MAP2K1 mutations were significantly associated with pERK expression.
There are no other biomarkers correlated with treatment responses following MEK1/2 inhibition.
High MEK1 expression is associated with neuroblastoma (show ARHGEF16 Proteins).
mutations in MAP2K1, which are frequently associated with neurological complications and intellectual disability, can be associated with a milder clinical and neurocognitive profile more typical of individuals with Noonan syndrome. Variability of expression may arise from a complex interplay between RAS/MAPK (show MAPK1 Proteins) pathway genotype, epigenetics, medical and obstetric factors, and environmental influences.
High MEK1 expression is associated with infant acute lymphoblastic leukemia.
Data show that combined therapy using HER2 (show ERBB2 Proteins) inhibitor and BRAF (show BRAF Proteins)/MEK inhibitor presented more significant redifferentiation effect on papillary thyroid cancer cells harboring BRAFV600E than BRAF (show BRAF Proteins)/MEK inhibitor alone.
MEK1 is constitutively and mainly phosphorylated at the Thr (show TRH Proteins)-292, Ser (show SIGLEC1 Proteins)-298, Thr (show TRH Proteins)-386, and Thr (show TRH Proteins)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (show TRH Proteins)-292, Ser (show SIGLEC1 Proteins)-298, Thr (show TRH Proteins)-386, and Thr (show TRH Proteins)-388 residues vary widely during activation and deactivation of the MAPK (show MAPK1 Proteins) pathway.
TNFRSF14 (show TNFRSF14 Proteins) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.
There was no statistically significant association between BRAF (show BRAF Proteins) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.
data suggest that, although short-term suppression of Mek1/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Cdk5 (show CDK5 Proteins) may play an important role in endoplasmic reticulum stress induced podocyte apoptosis through MEKK1/JNK (show MAPK8 Proteins) pathway in diabetic nephropathy.
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
High MEK1 expression is associated with Melanoma Metastasis.
cartilage-specific inactivation of miR322 in mice linked the loss of miR (show MLXIP Proteins)-322 to decreased MEK1 levels and to increased RAF (show RAF1 Proteins)/MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) pathway activation.
fluid shear stress induces autocrine TGF-beta (show TGFB1 Proteins)/ALK5 (show TGFBR1 Proteins)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.
Lgr4 (show LGR4 Proteins) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways.
FGF2 (show FGF2 Proteins) is an extracellular inducer of COUP-TFII (show NR2F2 Proteins) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (show NR2F2 Proteins) expression prior to the onset of osteogenic differentiation
REDD1 (show DDIT4 Proteins) is required for normal insulin (show INS Proteins)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (show DDIT4 Proteins), and mTOR (show FRAP1 Proteins)
blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (show LEPR Proteins) mice
in FGFR1 (show FGFR1 Proteins) signalling JNK1 (show MAPK8 Proteins) phosphorylation depends on ERK2 (show MAPK1 Proteins)
The data demonstrate that ERK (show MAPK1 Proteins) phosphorylation of UBF prevents DNA bending by its first two HMG (show SSRP1 Proteins) boxes, leading to a cooperative unfolding of the enhancesome
We propose that Erk2 MAP kinase (show MAPK1 Proteins) phosphorylation of Vg1RBP (show IGF2BP3 Proteins) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.
Extracellular signal-regulated kinase (ERK (show MAPK1 Proteins)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.
KSR (show KSR1 Proteins) interacts with a regulatory Raf (show RAF1 Proteins) molecule in cis (show CISH Proteins) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (show RAF1 Proteins) molecule in trans
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Genetic and biochemical evidences not only show that MEK1-MPK6 (show MAPK6 Proteins) cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1-MPK6 (show MAPK6 Proteins) cascade functions via working downstream of H2O2 and upstream of NO.
Data indicate that MEKK2 (show MAP3K2 Proteins) is required for the mekk1 (show MAP3K1 Proteins), mkk1 mkk2 (show MAP2K2 Proteins), and mpk4 (show MAPK4 Proteins) autoimmune phenotypes.
Data suggest that the MEKK1 (show MAP3K1 Proteins)-MKK1/MKK2 (show MAP2K2 Proteins)-MPK4 (show MAPK4 Proteins) kinase cascade negatively regulates MEKK2 (show MAP3K2 Proteins) and activation of MEKK2 (show MAP3K2 Proteins) triggers SUMM2-mediated immune responses.
miR (show MYLIP Proteins)-1826 plays an important role as tumor suppressor via CTNNB1 (show CTNNB1 Proteins)/MEK1/VEGFC (show VEGFC Proteins) downregulation in bladder cancer.
ETS1 (show ETS1 Proteins) is probably mediating high CIP2A (show KIAA1524 Proteins) expression in human cancers with increased EGFR (show EGFR Proteins)-MEK1/2-ERK (show MAPK1 Proteins) pathway activity
An analysis of the interation of MEKK1 (show MAP3K1 Proteins) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.
This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.
These results suggest that the formation of SUMO-1 (show SUMO1 Proteins) foci is regulated by the MEK-ERK (show MAPK1 Proteins) pathway and may induce apoptosis.
AtMEK1 is a crucial mediator in plant stress signal transduction.
double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (show MAP2K2 Proteins) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (show MAP3K1 Proteins) and mpk4 (show MAPK4 Proteins) mutants
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
ERK activator kinase 1
, MAP kinase kinase 1
, MAP kinase/Erk kinase 1
, MAPK/ERK kinase 1
, MAPKK 1
, dual specificity mitogen-activated protein kinase kinase 1
, mitogen-activated protein kinase kinase 1
, MEK 1
, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
, dual specificity mitogen activated protein kinase kinase 1
, mitogen activated protein kinase kinase 1
, protein kinase, mitogen activated, kinase 1, p45
, MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2)