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Human RAF1 Protein expressed in Wheat germ - ABIN1317314
Rodríguez-Muñoz, de la Torre-Madrid, Sánchez-Blázquez, Garzón: NO-released zinc supports the simultaneous binding of Raf-1 and PKC? cysteine-rich domains to HINT1 protein at the mu-opioid receptor. in Antioxidants & redox signaling 2011
Our report presents the second familial case of Noonan syndrome due to a germline p.S427G substitution in RAF] with no occurrence of a malignant tumor. It may suggest that carrying a germline mutation in the RAF1 oncogene (show RAB1A Proteins) is not associated with an increased risk of tumor development. Since RAF1 mutations have been observed as a somatic event in many types of cancer.
Data indicate that Raf-1 proto-oncogene (show RAB1A Proteins), serine-threonine kinase (show TLK2 Proteins) (RAF1) is a negative regulator of hepatocarcinogenesis.
we report a patient with an inherited RAF1-associated Noonan syndrome, presenting with an antenatally diagnosed abnormality of skull shape, bilateral subdural haematomas, of unknown cause, delayed myelination and polymicrogyria.
Raf1 may serve as a novel prognostic factor and potential target for improving the longterm outcome of nonsmall cell lung cancer (NSCLC).
Results provide evidence that RAF1 binding to SPRY4 (show SPRY4 Proteins) is regulated by miR (show MLXIP Proteins)-1908 in glioma tumors.
High RAF1 expression is associated with malignant melanoma.
two premature neonates with progressive biventricular hypertrophy found to have RAF1 variants in the CR2 domain, are reported.
Data indicate connector enhancer of kinase suppressor of Ras 1 (show CNKSR1 Proteins) protein (CNK1 (show CNKSR1 Proteins)) as a molecular platform that controls c-raf protein (RAF) and c-akt (show AKT1 Proteins) protein (AKT (show AKT1 Proteins)) signalling and determines cell fate decisions in a cell type- and cell stage-dependent manner.
CRAF is a bona fide alternative oncogene (show RAB1A Proteins) for BRAF (show BRAF Proteins)/NRAS (show NRAS Proteins)/GNAQ (show GNAQ Proteins)/GNA11 (show GNA11 Proteins) wild type melanomas
Authors evaluated the expression of known targets of miR (show MLXIP Proteins)-125a and found that sirtuin-7 (show SIRT7 Proteins), matrix metalloproteinase-11 (show MMP11 Proteins), and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR (show MLXIP Proteins)-125a.
cdk10 (show CDK10 Proteins) has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
data suggest that G alpha(i3), Shc (show SHC1 Proteins), Grb2 (show GRB2 Proteins), Ras, and Raf-1 link Src (show SRC Proteins) to activation of MAPK (show MAPK1 Proteins) and to the AT(2)-dependent increase in eNOS (show NOS3 Proteins) expression in PAECs
Our findings indicated that miR (show MLXIP Proteins)-195 inhibited WT and L613V RAF-1 induced hyperactive osteoblast differentiation in MC3T3-E1 cells by targeting RAF-1
Data indicate that Raf-1 proto-oncogene (show RAB1A Proteins), serine-threonine kinase (show CDK4 Proteins) (RAF1) is a negative regulator of hepatocarcinogenesis.
Results indicate that proto-oncogene c-RAF (CRAF) function affects postmitotic neural cell differentiation and points to a critical role of CRAF-dependent growth factor signaling pathway in the postmitotic development of adult-born neurons.
our studies demonstrate that PDE8A (show PDE8A Proteins) inhibition by enzymatic inhibitors or PDE8A (show PDE8A Proteins)-Raf-1 kinase complex disruptors decreases Teff cell adhesion and migration under flow, and represents a novel approach to target T cells in inflammation
BRAF (show BRAF Proteins) and ROKalpha (show ROCK2 Proteins) form independent RAF1 complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (show EGF Proteins)).
Mechanistically, BRAF (show BRAF Proteins) and RAF1 operate independently to balance MAPK (show MAPK1 Proteins) signaling: BRAF (show BRAF Proteins) promotes ERK (show EPHB2 Proteins) activation, while RAF1 dims stress kinase activation.
Neuroprotective (arylthio)cyclopentenone prostaglandins directly bind to c-Raf protein and protect cells from down-regulation of the c-Raf protein itself, resulting in protection against oxidative stress.
Additional Cyp (show PPIG Proteins) genes are disregulated in the absence of Zhx2 (show ZHX2 Proteins).
Zhx2 (show ZHX2 Proteins) is a novel regulator of Mup expression; Zhx2 (show ZHX2 Proteins) activates as well as represses expression of target genes
A- and B-Raf (show SNRPE Proteins) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (show VEGFA Proteins) protein stability.
Both c-Raf and B-Raf (show BRAF Proteins) are required for Ras-induced MEK1 (show MAP2K1 Proteins) and p42 (show EPB42 Proteins) MAP kinase (show MAPK1 Proteins) activation.
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
, RAF proto-oncogene serine/threonine-protein kinase
, proto-oncogene c-RAF
, raf proto-oncogene serine/threonine protein kinase
, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
, v-raf-1 murine leukemia viral oncogene homolog 1
, murine leukemia viral oncogene homolog
, serine/threonine protein kinase RAF1
, MIL proto-oncogene serine/threonine-protein kinase
, c-mil protein
, murine leukemia viral (v-raf-1) oncogene homolog 1
, RAF proto-oncogene serine/threonine-protein kinase-like
, Craf1 transforming
, murine sarcoma 3611 oncogene 1
, sarcoma 3611 oncogene
, v-raf-1 leukemia viral oncogene 1
, Proto-oncogene c-RAF