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Melittin Products

(Melittin (Melt))
Melittin-S: 1.4-fold less hemolytic and adopts a less organized secondary structure than melittin. Melittin: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na(+)-K(+)-ATPase and the H(+)-K(+)-ATPase. It increases the permeability of cell membranes to ions, particularly Na(+) and indirectly Ca(2+), because of the Na(+)-Ca(2+)-exchange. It acts synergistically with phospholipase A2. stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Latest Publications for our Melittin products

Buhrman, Rayahin, Cook, Federle, Gemeinhart: "Active, soluble recombinant melittin purified by extracting insoluble lysate of Escherichia coli without denaturation." in: Biotechnology progress, Vol. 29, Issue 5, pp. 1150-7, (2014) (PubMed).

Hood, Jallouk, Campbell, Ratner, Wickline: "Cytolytic nanoparticles attenuate HIV-1 infectivity." in: Antiviral therapy, Vol. 18, Issue 1, pp. 95-103, (2013) (PubMed).

Palm, Medzhitov: "Role of the inflammasome in defense against venoms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1809-14, (2013) (PubMed).

Liu, Bian, Sun, Hu, Klemm, Prinz, Rapoport, Hu: "Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 32, pp. E2146-54, (2012) (PubMed).

Shaw, Epand, Hsu, Mo, Epand, Yip: "Cationic peptide-induced remodelling of model membranes: direct visualization by in situ atomic force microscopy." in: Journal of structural biology, Vol. 162, Issue 1, pp. 121-38, (2008) (PubMed).

van den Bogaart, Guzmán, Mika, Poolman: "On the mechanism of pore formation by melittin." in: The Journal of biological chemistry, Vol. 283, Issue 49, pp. 33854-7, (2008) (PubMed).

van den Bogaart, Mika, Krasnikov, Poolman: "The lipid dependence of melittin action investigated by dual-color fluorescence burst analysis." in: Biophysical journal, Vol. 93, Issue 1, pp. 154-63, (2007) (PubMed).

Synonyms and alternative names related to Melittin

melittin (Melt), GB10355, Melt

Protein level used designations for Melittin

  • melittin
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