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Melittin Products

(Melittin (Melt))
Melittin-S: 1.4-fold less hemolytic and adopts a less organized secondary structure than melittin. Melittin: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na(+)-K(+)-ATPase and the H(+)-K(+)-ATPase. It increases the permeability of cell membranes to ions, particularly Na(+) and indirectly Ca(2+), because of the Na(+)-Ca(2+)-exchange. It acts synergistically with phospholipase A2.

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Latest Publications for our Melittin products

Buhrman, Rayahin, Cook, Federle, Gemeinhart: "Active, soluble recombinant melittin purified by extracting insoluble lysate of Escherichia coli without denaturation." in: Biotechnology progress, Vol. 29, Issue 5, pp. 1150-7, (2014) (PubMed).

Hood, Jallouk, Campbell, Ratner, Wickline: "Cytolytic nanoparticles attenuate HIV-1 infectivity." in: Antiviral therapy, Vol. 18, Issue 1, pp. 95-103, (2013) (PubMed).

Palm, Medzhitov: "Role of the inflammasome in defense against venoms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1809-14, (2013) (PubMed).

Liu, Bian, Sun, Hu, Klemm, Prinz, Rapoport, Hu: "Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 32, pp. E2146-54, (2012) (PubMed).

Shaw, Epand, Hsu, Mo, Epand, Yip: "Cationic peptide-induced remodelling of model membranes: direct visualization by in situ atomic force microscopy." in: Journal of structural biology, Vol. 162, Issue 1, pp. 121-38, (2008) (PubMed).

van den Bogaart, Guzmán, Mika, Poolman: "On the mechanism of pore formation by melittin." in: The Journal of biological chemistry, Vol. 283, Issue 49, pp. 33854-7, (2008) (PubMed).

van den Bogaart, Mika, Krasnikov, Poolman: "The lipid dependence of melittin action investigated by dual-color fluorescence burst analysis." in: Biophysical journal, Vol. 93, Issue 1, pp. 154-63, (2007) (PubMed).

Synonyms and alternative names related to Melittin

melittin (Melt), GB10355, Melt

Protein level used designations for Melittin

  • melittin
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