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Human Monoclonal AKR1B1 Primary Antibody for IHC (p), ELISA - ABIN513262
Ebert, Kisiela, Wsól, Maser: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. in Chemico-biological interactions 2011
Human Polyclonal AKR1B1 Primary Antibody for IHC, WB - ABIN4890159
Steuber, Heine, Podjarny, Klebe: Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. in Journal of molecular biology 2008
Human Polyclonal AKR1B1 Primary Antibody for IF, IHC (p) - ABIN389205
Gleissner, Sanders, Nadler, Ley: Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis. in Arteriosclerosis, thrombosis, and vascular biology 2008
Show all 3 Pubmed References
Human Polyclonal AKR1B1 Primary Antibody for WB - ABIN513260
Hernández-Ochoa, Robison, Contreras, Shen, Zhao, Schneider: Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle. in Experimental biology and medicine (Maywood, N.J.) 2012
Human Polyclonal AKR1B1 Primary Antibody for ICC, IF - ABIN4278953
Orton, Doucette, Maksym, MacLellan: Proteomic analysis of rat proximal tubule cells following stretch-induced apoptosis in an in vitro model of kidney obstruction. in Journal of proteomics 2014
genetic association studies in population in north India: Data suggest that an SNP in promoter region of aldose reductase (C-106T) is associated with peripheral neuropathy in patients with type 2 diabetes mellitus in the population studied.
Under hyperglycemic conditions, aldose reductase (AR)-mediated sorbitol formation and associated rise in cell volume, which subsequently results in platelet hyperactivation, occur.
An meta-analysis showed that aldose reductase C-106T variants appear to influence the risk for diabetic retinopathy in Chinese Han persons (meta-analysis).
AKR1B1 as a key modulator of tumor aggressiveness and suggests that pharmacologic inhibition of AKR1B1 has the potential to become a valuable therapeutic strategy for Basal-like breast cancer (BLBC).
Result indicate that the differential scanning fluorimetry (DSF) method is useful for enzyme inhibitor drug screening for the AKR superfamily, including AKR1B10 (show AKR1B10 Antibodies) and a structurally similar isoform AKR1B1.
The hyperosmotic AR gene expression was dependent on activation of metalloproteinases, autocrine/paracrine TGF-beta (show TGFB1 Antibodies) signaling, activation of p38 MAPK (show MAPK14 Antibodies), ERK1/2, and PI3K (show PIK3CA Antibodies) signal transduction pathways, and the transcriptional activity of NFAT5 (show NFAT5 Antibodies).
Aberrant DNA methylation (show HELLS Antibodies) of AKR1B1 could be potential screening markers of colorectal cancer.
-106T allele of AKR1B1 C-106T polymorphism may be associated with increased risk for essential hypertension in Chinese Han population.
These findings suggest a statistically significant association of AKR1B1 -106C>T polymorphism with retinopathy in North Indian patients
ALR (show GFER Antibodies) C(-106)T polymorphism was not associated with an increased risk of Diabetic Retinopathy; subgroup analysis showed a genetic association between ALR (show GFER Antibodies) C(-106)T polymorphism and the risk of Diabetic Retinopathy of type 1 Diabetes but not Diabetic Retinopathy of type 2 Diabetes(Meta-Analysis)
L-idose is the best alternative to D-glucose in studies on aldose reductase.
prostaglandin F synthase (show AKR1C3 Antibodies) activity of human and bovine aldo-keto reductases
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
Lii5-2 CTCL tumor antigen
, aldehyde reductase 1
, aldo-keto reductase family 1 member B1
, aldose reductase
, low Km aldose reductase
, Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)
, aldo-keto reductase family 1, member B4 (aldose reductase)
, 20-alpha-hydroxysteroid dehydrogenase
, aldehyde reductase
, aldo-keto reductase family 1, member B1 (aldose reductase)