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anti-Rat (Rattus) VPS4B Antibodies:
anti-Human VPS4B Antibodies:
anti-Mouse (Murine) VPS4B Antibodies:
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Human Polyclonal VPS4B Primary Antibody for IP, WB - ABIN438947
Du, Kazim, Dawes, Brown, Yang: The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III. in Traffic (Copenhagen, Denmark) 2013
Show all 2 Pubmed References
Human Polyclonal VPS4B Primary Antibody for ELISA, WB - ABIN564106
Ariumi, Kuroki, Maki, Ikeda, Dansako, Wakita, Kato: The ESCRT system is required for hepatitis C virus production. in PLoS ONE 2011
Show all 2 Pubmed References
Human Polyclonal VPS4B Primary Antibody for WB - ABIN657734
Morita, Colf, Karren, Sandrin, Rodesch, Sundquist: Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 3 Pubmed References
VPS4B might facilitate chondrocyte apoptosis in Osteoarthritis via p38 MAPK signaling pathway.
Knockdown of vps4b in zebrafish recapitulated the reduction of tooth size.
Our findings support a role for VPS4B in MM cell proliferation, adhesion, and drug resistance, and pave the way for a novel therapeutic approach targeting this molecule.
Lack of ALG-2, ALIX or Vps4B each prevents shedding, and repair of the injured cell membrane
Crystal structures of three molecular complexes reveal that IST1 binds to the MIT domains of VPS4 and LIP5.
ESCRT-III protein CHMP5 inhibits LIP5-mediated VPS4 activation by inducing a moderate conformational change within LIP5.
High Vacuolar protein sorting 4B results in more apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease.
Taken together, it was concluded that VPS4B and its DN mutant VPS4B-K180Q have anti-HBV effect in vivo, which helps develop molecular therapeutic strategies for HBV infection.
Protein kinase CK2 alpha is involved in the phosphorylation of the ESCRT-III subunits CHMP3 and CHMP2B, as well as of VPS4B/SKD1, an ATPase that mediates ESCRT-III disassembly.
VPS4B may promote the progression of Carcinoma, Non-Small-Cell Lung (NSCLC) and be a biotarget for NSCLCs therapy.
An inverse correlation between VPS4B expression and EGFR abundance is observed in breast tumors, and high-grade or recurrent breast carcinomas exhibit lower VPS4B expression.
It was found that neither siRNA knockdown of VPS4A and VPS4B expression nor the use of cell lines that inducibly express VPS4A or VPS4B dominant negative mutants, inhibited influenza virus budding.
ESCRT-III/VPS4 proteins function at centrosomes to help regulate their maintenance or proliferation and then at midbodies during abscission, thereby helping ensure the ordered progression through the different stages of cell division.
The expression and transport of ALG-2 in association with TSG101 and Vps4B are reported.
We propose that the MIT domain of Vps4b serves as a putative adaptor domain for the ESCRT-III complex involved in endosomal trafficking.
The crystal structure of monomeric apo human VPS4B was reported.
Four proteins (TSG101,Hrs,Aip1/Alix, and Vps4B) of the ESCRT (endosomal sorting complex required for transport) machinery were localized in T cells and macrophages by quantitative electron microscpy.
Upon coexpression of mutated CHMP3, CHMP4B, or CHMP4C forms, as well as of ATPase-defective Vps4A or Vps4B mutants, HBV assembly and egress were potently blocked.
Here, we report that dominant negative forms of Vps4A, Vps4B, and AIP1 inhibit HTLV-1 budding.
studies reveal how the VPS4 ATPases recognize their CHMP substrates to facilitate the membrane fission events required for the release of viruses, endosomal vesicles and daughter cells
a dominant negative form of the CHMP2B-interacting protein VPS4A, which alters multivesicular bodies, leads to accumulation and aggregation of Abeta as well as tau phosphorylation, mimicking the cellular changes in Alzheimer's disease
ATP hydrolysis would eliminate this interaction and subsequent nucleotide release causes the domains to rotate, which together lead to the disassembly of the SKD1 oligomer
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18\; the gene for the other resides on chromosome 16.
vacuolar protein sorting-associated protein 4B
, vacuolar protein sorting 4b
, vacuolar protein sorting 4B
, vacuolar protein sorting 4a
, vacuolar protein sorting 4 homolog B (S. cerevisiae)
, Vacuolar protein sorting-associating protein 4B
, vacuolar protein sorting factor 4B-like
, cell migration-inducing 1
, cell migration-inducing gene 1 protein
, suppressor of K(+) transport growth defect 1
, suppressor of K+ transport defect 1