VPS4B antibody (AA 1-117)

Catalog No. ABIN7175320

The Rabbit Polyclonal anti-VPS4B antibody (ABIN7175320) specifically detects VPS4B in WB, ELISA, IHC and IF. The antibody is reactive with Human samples.

Quick Overview for VPS4B antibody (AA 1-117) (ABIN7175320)

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS4B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-VPS4B Antibody

Binding Specificity: AA 1-117

Purpose: VPS4B Antibody

Cross-Reactivity: Mouse

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 4B protein (1-117AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for VPS4B

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Alternative Name: VPS4B

Background:

Background: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Aliases: 8030489C12Rik antibody, Cell migration inducing 1 antibody, Cell migration-inducing gene 1 protein antibody, MGC116271 antibody, MIG1 antibody, Protein SKD1 antibody, Skd1 antibody, SKD1B antibody, Suppressor of K(+) transport growth defect 1 antibody, Suppressor of K+ transport defect 1 antibody, Vacuolar protein sorting 4 homolog B (S. cerevisiae) antibody, Vacuolar protein sorting 4 homolog B antibody, Vacuolar protein sorting 4b antibody, Vacuolar protein sorting-associated protein 4B antibody, Vacuolar protein sorting-associating protein 4B antibody, VPS4 2 antibody, VPS42 antibody, Vps4b antibody, VPS4B_HUMAN antibody

UniProt: O75351

Pathways: Microtubule Dynamics, CXCR4-mediated Signaling Events