VPS4B antibody (C-Term)

Catalog No. ABIN657734

There is 1 publication for this product available. The Rabbit Polyclonal anti-VPS4B antibody is suitable to detect VPS4B in samples from Human. It has been validated for WB.

Quick Overview for VPS4B antibody (C-Term) (ABIN657734)

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS4B antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB32061

Product Details anti-VPS4B Antibody

Binding Specificity: AA 304-332, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This VPS4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-332 amino acids from the C-terminal region of human VPS4B.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: VPS4B Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-VPS4B antibody (ABIN657734)

Xu, Zhai, Ge, Liu, Tao: "Vacuolar Protein Sorting 4B (VPS4B) Regulates Apoptosis of Chondrocytes via p38 Mitogen-Activated Protein Kinases (MAPK) in Osteoarthritis." in: Inflammation, Vol. 40, Issue 6, pp. 1924-1932, (2018) (PubMed).

Target Details for VPS4B

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Alternative Name: VPS4B

Background: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18, the gene for the other resides on chromosome 16. [provided by RefSeq].

Molecular Weight: 49302

Gene ID: 9525

NCBI Accession: NP_004860

UniProt: O75351

Pathways: Microtubule Dynamics, CXCR4-mediated Signaling Events