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Human Polyclonal HAO1 Primary Antibody for IHC, IHC (p) - ABIN4320752
Kampf, Mardinoglu, Fagerberg, Hallström, Edlund, Lundberg, Pontén, Nielsen, Uhlen: The human liver-specific proteome defined by transcriptomics and antibody-based profiling. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
Cow (Bovine) Polyclonal HAO1 Primary Antibody for WB - ABIN2775438
Williams, Cregeen, Rumsby: Identification and expression of a cDNA for human glycolate oxidase. in Biochimica et biophysica acta 2000
Show all 2 Pubmed References
The study presents the first spectroscopic evidence of the formation of an intermediate with absorbance features resembling those of a flavosemiquinone in the oxidative half-reaction of glycolate oxidase.
The inhibitor heteroatoms interact with five active-site residues that have been implicated in catalysis in homologous flavodehydrogenases of L-2-hydroxy acids. In addition, the chlorophenyl substituent is surrounded by nonconserved hydrophobic residues.
These inhibitions suggest that glycolate binds to the active site of the reduced enzyme, and that DCIP also has affinity for the oxidized enzyme.
Active site and loop 4 movements within human glycolate oxidase.
Decreasing hepatic glycolate oxidase and HYPDH expression decreases oxalate excretion.
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.
hydroxyacid oxidase 1
, Hydroxyacid oxidase 1
, hydroxyacid oxidase (glycolate oxidase) 1
, (S)-2-hydroxy-acid oxidase
, glycolate oxidase
, hydroxyacid oxidase 1, liver
, glycolate oxidase 1