Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Rat (Rattus) Antibodies:
anti-Mouse (Murine) Antibodies:
Go to our pre-filtered search.
Human Polyclonal GABPA Primary Antibody for WB - ABIN6140887
Zhao, Tao, Qi, Xu, Yin, Peng: Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress. in Redox biology 2018
Show all 3 Pubmed References
Human Polyclonal GABPA Primary Antibody for WB - ABIN6680497
Chen, Jiang, Li, Bai, Zhao, Zhang, Zhang: Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats. in Oncotarget 2018
Show all 3 Pubmed References
Human Monoclonal GABPA Primary Antibody for ICC, ELISA - ABIN969163
Batchelor, Piper, de la Brousse, McKnight, Wolberger: The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. in Science (New York, N.Y.) 1998
Show all 3 Pubmed References
Human Polyclonal GABPA Primary Antibody for IF (p), IHC (p) - ABIN1714176
Chang, Wu, Xu, Liao, Wu, Cheng: Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation. in Molecules (Basel, Switzerland) 2015
Human Polyclonal GABPA Primary Antibody for ICC, IF - ABIN4313121
Sharma, Massie, Butter, Mann, Bon, Ramos-Montoya, Menon, Stark, Lamb, Scott, Warren, Neal, Mills: The ETS family member GABP? modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer. in Nucleic acids research 2014
Human Polyclonal GABPA Primary Antibody for WB - ABIN6140889
Adeoye, Asenuga, Oyagbemi, Omobowale, Adedapo: The Protective Effect of the Ethanol Leaf Extract of Andrographis Paniculata on Cisplatin-Induced Acute Kidney Injury in Rats Through nrf2/KIM-1 Signalling Pathway. in Drug research 2018
a positive correlation between GABPA and DICER1 expression was seen in multiple types of malignancies. Taken together, despite its stimulatory effect on the mutant TERT promoter and telomerase activation, GABPA may itself act as a tumor suppressor rather than an oncogenic factor to inhibit invasion/metastasis in thyroid carcinomas.
enhanced ETS factor activity and the transcription of ETS family target genes related to spliceosome function and cell death induction via alternate MCL1 splicing, is reported.
Data indicate the essential role of the GABP transcription factor in activating translocase of inner mitochondrial membrane 23 TIMM23 and TIMM23B expression.
Collectively, our data indicate that GABPA inhibits hepatocellular carcinoma cell migration and could serve as a novel biomarker for prognosis
CRISPR-mediated reversal of mutant TERT promoters, or deletion of its long-range interacting chromatin, abrogates GABPA binding and long-range interactions, leading to depletion of active histone marks, loss of POL2 recruitment, and suppression of TERT transcription
potential mechanism of TERT reactivation mediated by a novel long-range chromatin interaction between the TERT promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT promoters but not in wild-type promoters.
a key role for GABPA/B1 as the critical ETS transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma.
Analyses of data sets link GABPa to cognitive disorders, diabetes, KRAB zinc finger (KRAB-ZNF), and human-specific genes.
ELF1 binding occurs at both TERT promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS motifs in the TERT promoter region.
The results suggest that NRF-2alpha is a regulator of SIRT3 expression and may shed light on how SIRT3 is upregulated during nutrient stress.
GABPalpha Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1
Expression of the ETS transcription factor GABPalpha is positively correlated to the BCR-ABL1/ABL1 ratio in CML patients and affects imatinib sensitivity in vitro.
study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b as a novel GABP target gene
GABPA thus directly links TERT promoter mutations to aberrant expression in multiple cancers.
GABPA exhibits an increase in binding signal with higher numbers of ETS motifs per promoter. Analysis of the distance between inverted pairs of ETS motifs within promoters and binding by p53, ETS1 and GABPA, shows a coordination of binding for the 3.
results demonstrate the functional importance of the C/EBPalpha C-terminus beyond the bZIP DNA-binding and dimerization region, which may mediate cooperative activation by C/EBPalpha and GABP of myeloid-specific genes
GABP alpha is required for YAP expression in vitro and in vivo, and that YAP is an important effector downstream of GABP for cell survival and cell-cycle progression.
When NRF-2alpha and NRF-2beta form a complex, the nuclear import of NRF-2alphabeta becomes strictly dependent on the nuclear localization signal within NRF-2beta.
Results suggest that the NRF-2 A/C polymorphism is associated with endurance performance at the elite level in a Spanish population.
although ELK1 and GABPA ultimately control the same biological process, they do so by regulating different cohorts of target genes associated with cytoskeletal functions and cell migration contro
Depletion of GABPalpha impairs T-cell homeostatic survival, proliferation, and antigen-induced responses in vivo.
conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression
Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.
NRF-2 and NRF-1 operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.
Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx and Etv6 transcription factors and prosurvival Bcl-2 family members including Bcl-2, Bcl-X(L), and Mcl-1 as direct GABP target genes.
Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.
chemical shift and secondary structure of the PNT/SAM domains
phosphorylation of threonine 280 in GABPalpha triggers reorganizations of the quaternary structure of GABP
Erralpha and GA-binding protein a partner with PGC-1alpha in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes
Gabpa function is essential and is not compensated for by other ETS transcription factors and is consistent with a specific requirement for Gabp expression for the maintenance of target genes involved in embryo essential mitochondrial cellular functions
GABP is essential for the regulation of IL-7Ralpha expression in T cells.
Binding of GABP to the GAA/CF6 bi-directional promoter provides the potential for autoregulation of GABP alpha expression and confirms the importance of GABP in the coordinate expression of respiratory chain components
GABPalpha upregulates the expression of Oct-3/4 via downregulation of Oct-3/4 repressors.
GABPalpha is necessary and sufficient for re-entry into the cell cycle and it regulates a pathway that is distinct from that of D-type cyclins and CDKs.
GABP transcription factor aids in the structural formation and function of neuromuscular junctions by regulating the expression of postsynaptic genes
Deficiency of GABPalpha, the DNA-binding subunit of GABP, resulted in profoundly defective B cell development and a compromised humoral immune response, in addition to thymic developmental defects.
These data indicate that GABP is dispensable for synapse-specific transcription and maintenance of normal acetylcholine receptor expression at synapses.
Because NRG-1 signaling is not expected to alter the function of the C-terminal region, which remains in these cells, these results suggest that GABPbeta, or other interacting components, rather than GABPalpha directly, is targeted by NRG-1 signaling.
Ther is a direct structural link between GABP and a central component of the transcriptional machinery.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
GA binding protein transcription factor, alpha subunit 60kDa
, transcription factor GABP alpha subunit
, GA binding protein transcription factor, alpha subunit (60kD)
, GA-binding protein alpha chain-like
, GA repeat binding protein, alpha
, GA-binding protein alpha chain
, nuclear respiratory factor 2 alpha
, GA binding protein transcription factor alpha subunit 60kDa
, GABP subunit alpha
, human nuclear respiratory factor-2 subunit alpha
, nuclear respiratory factor 2 alpha subunit
, nuclear respiratory factor 2 subunit alpha
, transcription factor E4TF1-60
, GA repeat binding protein alpha
, GA-binding protein alpha-subunit
, E4tf1-60 transcription factor