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anti-Mouse (Murine) OXT Antibodies:
anti-Rat (Rattus) OXT Antibodies:
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The abnormal social behaviors of Dio3 (show DIO3 Antibodies)-/- mice were associated with sexually dimorphic alterations in the physiology of oxytocin (OXT) and arginine vasopressin (AVP (show AVP Antibodies)), 2 neuropeptides with important roles in determining social interactions.
Activation of the oxytocin receptor (show OXTR Antibodies) in brain regions facilitates social defeat posture.
the absence of OT leads to significant changes in the expression of the studied genes (OTR (show OXTR Antibodies), ERalpha (show ESR1 Antibodies), ERbeta (show ESR2 Antibodies), V1aR (show AVPR1A Antibodies)), and these changes may contribute to the decreased sexual behavior observed in OT gene knockout females.
These results reveal that Oxt protects pancreatic beta cells against death caused by metabolic stress, and Oxt signaling may be a potential therapeutic target.
CA3 (show CA3 Antibodies) pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons.
These results identify G9a (show EHMT2 Antibodies)-induced histone methylation at the OXT and AVP (show AVP Antibodies) promoters in the Basolateral Amygdala as a mechanism for mediating stress-induced lasting behavioral depression and its reversal by exercise.
OXT was up-regulated in both hypothalamic magnocellular neurosecretory cells and parvocellular cells by chronic inflammation, and also that OXT in the PVN-spinal pathway may be involved in sensory modulation
Oxtr (show OXTR Antibodies) signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Oxt conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning.
Nos1 (show NOS1 Antibodies) neurons of paraventricular nucleus of the hypothalamus promote negative energy balance through changes in feeding and energy expenditure, whereas OXT neurons regulate energy expenditure alone.
Data suggest that oxytocin plays a crucial role in the sexual behavior display, number of released oocytes and density of dendritic spines in the MePD (show THOP1 Antibodies) of female mice without affecting AVP (show AVP Antibodies) plasma concentration
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1 (show IGF1 Antibodies)/oxytocin system.
loop status modulates dimerization via long-range effects on neurophysin (show AVP Antibodies) conformation involving neighboring Phe22 as a key intermediary
Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 (show EDN1 Antibodies) and PGF (show PGF Antibodies)(2alpha) within the corpus luteum.
A significant moderating effect of OXT genotype (rs2740210) on the relationship between social support and psychiatric distress was detected
These results suggest that OXT and OXTR (show OXTR Antibodies) are controlled mainly by E2 in the placenta via ESR1 (show ESR1 Antibodies) and thus may play physiological functions in the human placenta during the late stage of pregnancy.
Study found a higher expression of paraventricular nucleus OXT in the mood disorder patients than in the control subjects, and observed a clear co-localization of androgen receptor (show AR Antibodies) in OXT-expressing neurons, both in the cytoplasm and in the nucleus. In addition, a significant decrease in OXT-mRNA levels was observed after pre-incubation of the SK-N-SH cells with testosterone.
Serum and prostatic oxytocin levels are increased in the PCa (show FLVCR1 Antibodies) subjects. Serum oxytocin level may be a biomarker for PCa (show FLVCR1 Antibodies) in the future. Oxytocin increases PCa (show FLVCR1 Antibodies) growth and APPL1 (show APPL1 Antibodies) expression.
Obese children had significantly higher irisin (show FNDC5 Antibodies) and lower oxytocin levels than the healthy controls.
study found that rs6133010 in the OXT gene is associated with alcohol dependence in the northern Chinese Han population
OXT levels were lowest in anorexia nervosa, higher in healthy controls, and highest in obesity. There were positive associations between OXT and body mass index, total, visceral, and subcutaneous fat, and bone mineral density.
epigenetic modification of OXT is linked to several overt measures of sociability
Oxytocin prevents cartilage matrix destruction via regulating MMP1 (show MMP1 Antibodies) and MMP13 (show MMP13 Antibodies).
This is the first known study to show a significant association between callous unemotional traits in children and adolescents with extreme, persistent pervasive aggression and a polymorphism on the oxytocin receptor (show OXTR Antibodies).
The presence of oxytocin in the mare (show C16orf35 Antibodies) uterus was determined by radioimmunoassay of tissue extracts and uterine lavage fluid, and by immunohistochemistry.
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
, oxytocin-neurophysin 1
, oxytocin, prepro- (neurophysin I)
, oxytocin, prepropeptide
, oxytocin/neurophysin (Oxt) gene, complete gene, complete cds
, neurophysin I
, oxytocin-neurophysin I, preproprotein
, oxytocin-neurophysin I