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anti-Mouse (Murine) OXT Antibodies:
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Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
Oxytocin (OT) mRNA and protein levels were lower in the corpus luteum of pregnancy than in the corpus luteum of the estrous cycle.
These data suggest that cortisol affects oxytocin synthesis and secretion in bovine ovarian cells, by acting on the expression of key genes, that may impair ovary
Binding of oestrogen receptor-related receptor alpha to the oxytocin promoter binding site is demonstrated, suggesting the involvement of this receptor in oestrogen-dependent up-regulation.
data demonstrate an effect of dimerization in the unliganded state on the hormone-binding site involving residues that interact with hormone residue 2, & identify Ser25 & Ile26 as likely intermediaries between the sites of dimerization & hormone binding
loop status modulates dimerization via long-range effects on neurophysin conformation involving neighboring Phe22 as a key intermediary
Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 and PGF(2alpha) within the corpus luteum.
The results suggest that there is an age-dependent association between visual attention for social cues and oxytocin (OT) levels in infants and children, and that the development of visual attention to the eyes as social cues is associated with both OXTR polymorphisms and OT levels.
Although some SNPs were associated at an alpha level of .05 with breastfeeding, they did not survive multiple testing correction. Authors conclude that SNPs within or nearby OXT and OXTR are unlikely to have large effects on breastfeeding behavior.
Oxytocin gene polymorphisms and parenting G x E interaction on social anxiety levels in adolescents.
serum oxytocin levels were higher among women than men and were negatively associated with strength of belief in life after death
A significant moderating effect of OXT genotype (rs2740210) on the relationship between social support and psychiatric distress was detected
findings suggested more significant plasma oxytocin dysregulation in the patients in the bipolar II disorder group than in the major depressive disorder patients and controls, both before and after treatment
Oxytocin level did not vary significantly between healthy controls, healthy controls with a history of sexual abuse, and psychogenic non-epileptic seizure patients with a history of sexual abuse.
These results suggest that OXT and OXTR are controlled mainly by E2 in the placenta via ESR1 and thus may play physiological functions in the human placenta during the late stage of pregnancy.
Study found a higher expression of paraventricular nucleus OXT in the mood disorder patients than in the control subjects, and observed a clear co-localization of androgen receptor in OXT-expressing neurons, both in the cytoplasm and in the nucleus. In addition, a significant decrease in OXT-mRNA levels was observed after pre-incubation of the SK-N-SH cells with testosterone.
Serum and prostatic oxytocin levels are increased in the PCa subjects. Serum oxytocin level may be a biomarker for PCa in the future. Oxytocin increases PCa growth and APPL1 expression.
Obese children had significantly higher irisin and lower oxytocin levels than the healthy controls.
study found that rs6133010 in the OXT gene is associated with alcohol dependence in the northern Chinese Han population
OXT levels were lowest in anorexia nervosa, higher in healthy controls, and highest in obesity. There were positive associations between OXT and body mass index, total, visceral, and subcutaneous fat, and bone mineral density.
epigenetic modification of OXT is linked to several overt measures of sociability
Hormonal changes in estradiol, progesterone, or oxytocin do not predict differences in the pain perception of women in the peripartum or postpartum period.
Oxytocin prevents cartilage matrix destruction via regulating MMP1 and MMP13.
Low oxytocin expression is associated with diabetic metabolic syndrome.
Oxytocin levels were lower in autistic patients compared to controls.
Children with Prader-Willi syndrome have elevated plasma oxytocin levels.
This is the first known study to show a significant association between callous unemotional traits in children and adolescents with extreme, persistent pervasive aggression and a polymorphism on the oxytocin receptor.
The presence of oxytocin in the mare uterus was determined by radioimmunoassay of tissue extracts and uterine lavage fluid, and by immunohistochemistry.
The effects of oestrogen and progesterone in the regulation of oxytocin gene expression in equine endometrium were examined.
The roles of oxytocin and dinoprost in persistent mating-induced endometritis in mares are reported.
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
, oxytocin-neurophysin 1
, oxytocin, prepro- (neurophysin I)
, oxytocin, prepropeptide
, oxytocin/neurophysin (Oxt) gene, complete gene, complete cds
, neurophysin I
, oxytocin-neurophysin I, preproprotein
, oxytocin-neurophysin I