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the absence of OT leads to significant changes in the expression of the studied genes (OTR (show OXTR Proteins), ERalpha (show ESR1 Proteins), ERbeta (show ESR2 Proteins), V1aR (show AVPR1A Proteins)), and these changes may contribute to the decreased sexual behavior observed in OT gene knockout females.
These results reveal that Oxt protects pancreatic beta cells against death caused by metabolic stress, and Oxt signaling may be a potential therapeutic target.
CA3 (show CA3 Proteins) pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons.
These results identify G9a (show EHMT2 Proteins)-induced histone methylation at the OXT and AVP (show AVP Proteins) promoters in the Basolateral Amygdala as a mechanism for mediating stress-induced lasting behavioral depression and its reversal by exercise.
OXT was up-regulated in both hypothalamic magnocellular neurosecretory cells and parvocellular cells by chronic inflammation, and also that OXT in the PVN-spinal pathway may be involved in sensory modulation
Oxtr (show OXTR Proteins) signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Oxt conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning.
Nos1 (show NOS1 Proteins) neurons of paraventricular nucleus of the hypothalamus promote negative energy balance through changes in feeding and energy expenditure, whereas OXT neurons regulate energy expenditure alone.
Data suggest that oxytocin plays a crucial role in the sexual behavior display, number of released oocytes and density of dendritic spines in the MePD (show THOP1 Proteins) of female mice without affecting AVP (show AVP Proteins) plasma concentration
lactic acid microbes accelerate wound healing via the neuropeptide hormone oxytocin
CD38 in the nucleus accumbens and oxytocin are critical in paternal behavior.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1 (show IGF1 Proteins)/oxytocin system.
loop status modulates dimerization via long-range effects on neurophysin (show AVP Proteins) conformation involving neighboring Phe22 as a key intermediary
Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 (show EDN1 Proteins) and PGF (show PGF Proteins)(2alpha) within the corpus luteum.
study found that rs6133010 in the OXT gene is associated with alcohol dependence in the northern Chinese Han population
OXT levels were lowest in anorexia nervosa, higher in healthy controls, and highest in obesity. There were positive associations between OXT and body mass index, total, visceral, and subcutaneous fat, and bone mineral density.
epigenetic modification of OXT is linked to several overt measures of sociability
Oxytocin prevents cartilage matrix destruction via regulating MMP1 (show MMP1 Proteins) and MMP13 (show MMP13 Proteins).
This is the first known study to show a significant association between callous unemotional traits in children and adolescents with extreme, persistent pervasive aggression and a polymorphism on the oxytocin receptor (show OXTR Proteins).
Oxytocin activates NF-kappaB (show NFKB1 Proteins)-mediated inflammatory pathways in human gestational tissues in normal parturition.
Report for the first time of a significant genetic association of OXT and AVP (show AVP Proteins) with schizophrenia
nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38
Patients with poor outcome after aneurysmal subarachnoid hemorrhage have lower AVP (show AVP Proteins) and OXT levels in cerebrospinal fluid.
dysregulation of OXT, AVP (show AVP Proteins) and/or testosterone systems exist in mothers of autistic children.
The presence of oxytocin in the mare (show C16orf35 Proteins) uterus was determined by radioimmunoassay of tissue extracts and uterine lavage fluid, and by immunohistochemistry.
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
, oxytocin-neurophysin 1
, oxytocin, prepro- (neurophysin I)
, oxytocin, prepropeptide
, oxytocin/neurophysin (Oxt) gene, complete gene, complete cds
, neurophysin I
, oxytocin-neurophysin I, preproprotein
, oxytocin-neurophysin I