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Full name:: phosphodiesterase 4C, CAMP-Specific Proteins (PDE4C)

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Synonyms:: DPDE1, dunce, E130301F19Rik, im:7160317, PDE4C, si:dkey-149i17.5

list all proteins	Gene Name	GeneID	UniProt
	PDE4C	110385	Q3UEI1
	PDE4C	5143	Q08493
	PDE4C	290646
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Chimpanzee phosphodiesterase 4C, CAMP-Specific (PDE4C) interaction partners

Mouse (Murine) phosphodiesterase 4C, CAMP-Specific (PDE4C) interaction partners

findings identify PC2 and PDE4C as unique components of an AKAP complex in primary cilia and reveal a common mechanism for dysregulation of cAMP signaling in cystic kidney diseases arising from different gene mutations

Human phosphodiesterase 4C, CAMP-Specific (PDE4C) interaction partners

Data show that PDE4C is downregulated through promoter hypermethylation in glioma.
PDE4A (show PDE4A Proteins) and PDE4C work in redundant fashion to mediate the loss of inhibitory PGE2 signaling in lung fibroblasts.

phosphodiesterase 4C, CAMP-Specific (PDE4C) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with phosphodiesterase 4C, CAMP-Specific (PDE4C)

phosphodiesterase 4C (PDE4C)
phosphodiesterase 4C, cAMP-specific a (pde4ca)
phosphodiesterase 4C (pde4c)
phosphodiesterase 4C, cAMP specific (Pde4c)
phosphodiesterase 4C (Pde4c)

DPDE1 protein
dunce protein
E130301F19Rik protein
im:7160317 protein
PDE4C protein
si:dkey-149i17.5 protein

Protein level used designations for PDE4C

cAMP-specific 3',5'-cyclic phosphodiesterase 4C , phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) , Pde43 , phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog) , PDE21 , phosphodiesterase E1 dunce homolog , cAMP-specific 35-cyclic phosphodiesterase 4C

GENE ID	SPECIES
524624	Bos taurus
565259	Danio rerio
609938	Canis lupus familiaris
720171	Macaca mulatta
748644	Pan troglodytes
100380081	Xenopus (Silurana) tropicalis
110385	Mus musculus
5143	Homo sapiens
290646	Rattus norvegicus

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