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Human MUC1 Protein expressed in Wheat germ - ABIN1311631
Lu, Ladd, Feng, Wu, Goodell, Pitteri, Li, Prentice, Hanash, Disis: Evaluation of known oncoantibodies, HER2, p53, and cyclin B1, in prediagnostic breast cancer sera. in Cancer prevention research (Philadelphia, Pa.) 2012
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The expression profile of studied Mucins MUC16 (show MUC16 Proteins) and MUC1 and truncated O-glycans was not associated with the site of origin of ovarian cancer (OVCA) cell lines
MUC1 contributes to immune escape in an aggressive form of triple-negative breast cancer.MUC1 drives PD-L1 (show CD274 Proteins) expression in triple-negative breast cancer cells.
Results show MUC1 expression highly expressed at mRNA and protein levels in esophageal squamous cell carcinoma (ESCC). MUC1 expression correlated with tumor invasion, lymph node metastasis, and TNM (show ODZ1 Proteins) staging.
Decreased expression of MUC1 is an independent marker for endometrial receptivity in recurrent implantation failure.
The glycosylation level of CA153 was found to increase with increasing breast cancer stage in the sandwich assay. The assay system appeared to efficiently discriminate breast cancer stage I (sensitivity: 63%, specificity: 69%), IIA (sensitivity: 77%, specificity: 75%), IIB (sensitivity: 69%, specificity: 86%) and III (sensitivity: 80%, specificity: 65%) from benign breast disease.
High MUC1 expression is associated with cervical cancer.
MUC1 was a potential molecular target may help explain the role of lincRNA-ROR/miR (show MLXIP Proteins)-145 for invasion and metastasis in Triple-negative breast cancer cell lines.
We have analysed the tumour-associated carbohydrate antigens sialyl-Lewis x (SLe(x)) and sialyl-Tn (STn) on MUC1 and MUC5AC in Pancreatic adenocarcinoma (PDAC)tissues. immunoprecipitation of MUC5AC from positive PDAC tissues and subsequent SLe(x) immunodetection confirmed the presence of SLe(x) on MUC5AC. Altogether, MUC5AC-SLe(x) glycoform is present in PDAC and can be regarded as potential biomarker.
High MUC1 expression is associated with breast cancer metastasis.
These results revealed that serum WFA-sialylated MUC1 was associated with histological features of hepatocellular carcinoma and recurrence after curative therapy.
The results indicate that Muc1 gene is significantly associated with litter size in pigs.
The epiblast expressed epithelial markers, MUC1 and E-CADHERIN (show CDH1 Proteins), and the pluripotency markers, DNMT3B (show DNMT3B Proteins) and CRIPTO (show TDGF1 Proteins).
Endometrial expressions of MUC1 and cytokine genes differed among normal, fertile versus diseased, and subfertile dairy cows.
Bovine Muc1 prevents binding of bacteria to human intestinal cells and may have a role in preventing the binding of common enteropathogenic bacteria to human intestinal epithelial surfaces.
concluded that bovine Muc1 protein is probably an inducible innate immune effector and an important component of the first line of defense against bacterial invasion of epithelial surfaces
MUC1 plays an important role in protection against severe pneumococcal disease, potentially mediated by facilitating macrophage phagocytosis.
this study implicates the MUC1 as a critical and dynamic component of the innate host response that limits the severity of influenza and provides the foundation for exploration of MUC1 in resolving inflammatory disease
Tumor growth delays observed by tumor irradiation combined with MVA (show MYO5A Proteins)-MUC1-IL-2 (show IL2 Proteins) vaccine were significantly more prolonged than those observed by vaccine, radiation, or radiation with MVA (show MYO5A Proteins) empty vector.
Muc1 has anti-fibrotic properties in the mouse lung.
our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1 (show NRP1 Proteins)-dependent VEGFR (show KDR Proteins) signaling in PDA cells.
Low expression of MUC1 is associated with lung carcinogenesis.
Using an extensive collection of novel murine cell lines we have identified distinct roles for Kras and Pten on MUC1 and EMT (show ITK Proteins) in vivo and in vitro. The data has implications for future design of combination therapies targeting Kras mutations, Pten deletions and MUC1 vaccines.
Gp91phox (show CYBB Proteins) NADPH oxidase (show NOX1 Proteins) modulates litter size by up-regulating mucin1 expression in the uterus of mice.
In summary, we have demonstrated that MUC1 on immune cells is a novel regulator of the NLRP3 (show NLRP3 Proteins) inflammasome, and propose this is mediated by an interaction with signalling components at the cytoplasmic domains of TLRs that involves inhibition of IRAK4 (show IRAK4 Proteins) activation.
MUC1 regulates IL-1beta (show IL1B Proteins) secretion induced by the NLRP3 (show NLRP3 Proteins)-activating bacteria Haemophilus influenzae but not bacteria that activate other inflammasomes.
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
, H23 antigen
, breast carcinoma-associated antigen DF3
, cancer antigen 15-3
, carcinoma-associated mucin
, krebs von den Lungen-6
, mucin 1, transmembrane
, peanut-reactive urinary mucin
, polymorphic epithelial mucin
, tumor associated epithelial mucin
, tumor-associated epithelial membrane antigen
, tumor-associated mucin
, endometrial mucin-1
, epithelial mucin