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Human MUC1 Protein expressed in Wheat germ - ABIN1311631
Lu, Ladd, Feng, Wu, Goodell, Pitteri, Li, Prentice, Hanash, Disis: Evaluation of known oncoantibodies, HER2, p53, and cyclin B1, in prediagnostic breast cancer sera. in Cancer prevention research (Philadelphia, Pa.) 2012
Show all 2 Pubmed References
High MUC1 expression is associated with cervical cancer.
MUC1 was a potential molecular target may help explain the role of lincRNA-ROR/miR (show MLXIP Proteins)-145 for invasion and metastasis in Triple-negative breast cancer cell lines.
We have analysed the tumour-associated carbohydrate antigens sialyl-Lewis x (SLe(x)) and sialyl-Tn (STn) on MUC1 and MUC5AC in Pancreatic adenocarcinoma (PDAC)tissues. immunoprecipitation of MUC5AC from positive PDAC tissues and subsequent SLe(x) immunodetection confirmed the presence of SLe(x) on MUC5AC. Altogether, MUC5AC-SLe(x) glycoform is present in PDAC and can be regarded as potential biomarker.
High MUC1 expression is associated with breast cancer metastasis.
These results revealed that serum WFA-sialylated MUC1 was associated with histological features of hepatocellular carcinoma and recurrence after curative therapy.
this study shows that basaloid squamous cell carcinoma and basal cell carcinoma of the head and neck can be readily distinguished by a limited panel consisting primarily of EMA, and supported by SOX2 and p16
In the in vitro tests, JFD-WS effectively inhibited HUVEC proliferation, migration, tube formation and VEGFR2 (show KDR Proteins) phosphorylation. Additionally, JFD-WS inhibited the formation of blood vessels in chick chorioallantoic membrane. While inhibiting the xenograft tumor growth in experimental mice, JFD-WS decreased the plasma MUC1 levels
Quercetin suppressed breast cancer stem cell proliferation, self-renewal, and invasiveness. It also lowered the expression levels of proteins related to tumorigenesis and cancer progression, such as aldehyde dehydrogenase 1A1 (show ALDH1A1 Proteins), C-X-C chemokine receptor type 4 (show CXCR4 Proteins), mucin 1, and epithelial cell adhesion molecules.
the proposed ECL immunosensor opened a new era for sensitive CA15-3 evaluation and offered a promising platform for clinical breast cancer diagnostics.
MUC1-mediated nucleotide metabolism plays a key role in facilitating radiation resistance in pancreatic cancer and targeted effectively through glycolytic inhibition
The results indicate that Muc1 gene is significantly associated with litter size in pigs.
The epiblast expressed epithelial markers, MUC1 and E-CADHERIN (show CDH1 Proteins), and the pluripotency markers, DNMT3B (show DNMT3B Proteins) and CRIPTO (show TDGF1 Proteins).
Endometrial expressions of MUC1 and cytokine genes differed among normal, fertile versus diseased, and subfertile dairy cows.
Bovine Muc1 prevents binding of bacteria to human intestinal cells and may have a role in preventing the binding of common enteropathogenic bacteria to human intestinal epithelial surfaces.
concluded that bovine Muc1 protein is probably an inducible innate immune effector and an important component of the first line of defense against bacterial invasion of epithelial surfaces
this study implicates the MUC1 as a critical and dynamic component of the innate host response that limits the severity of influenza and provides the foundation for exploration of MUC1 in resolving inflammatory disease
Tumor growth delays observed by tumor irradiation combined with MVA (show MYO5A Proteins)-MUC1-IL-2 (show IL2 Proteins) vaccine were significantly more prolonged than those observed by vaccine, radiation, or radiation with MVA (show MYO5A Proteins) empty vector.
Muc1 has anti-fibrotic properties in the mouse lung.
our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1 (show NRP1 Proteins)-dependent VEGFR (show KDR Proteins) signaling in PDA cells.
Low expression of MUC1 is associated with lung carcinogenesis.
Using an extensive collection of novel murine cell lines we have identified distinct roles for Kras and Pten on MUC1 and EMT (show ITK Proteins) in vivo and in vitro. The data has implications for future design of combination therapies targeting Kras mutations, Pten deletions and MUC1 vaccines.
Gp91phox (show CYBB Proteins) NADPH oxidase (show NOX1 Proteins) modulates litter size by up-regulating mucin1 expression in the uterus of mice.
In summary, we have demonstrated that MUC1 on immune cells is a novel regulator of the NLRP3 (show NLRP3 Proteins) inflammasome, and propose this is mediated by an interaction with signalling components at the cytoplasmic domains of TLRs that involves inhibition of IRAK4 (show IRAK4 Proteins) activation.
MUC1 regulates IL-1beta (show IL1B Proteins) secretion induced by the NLRP3 (show NLRP3 Proteins)-activating bacteria Haemophilus influenzae but not bacteria that activate other inflammasomes.
Muc1 protection during acute kidney injury proceeds by enhancing both the HIF-1 (show HIF1A Proteins) and beta-catenin (show CTNNB1 Proteins) protective pathways.
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
, H23 antigen
, breast carcinoma-associated antigen DF3
, cancer antigen 15-3
, carcinoma-associated mucin
, krebs von den Lungen-6
, mucin 1, transmembrane
, peanut-reactive urinary mucin
, polymorphic epithelial mucin
, tumor associated epithelial mucin
, tumor-associated epithelial membrane antigen
, tumor-associated mucin
, endometrial mucin-1
, epithelial mucin