MUC1 Protein (AA 24-380) (Fc Tag)
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- Target See all MUC1 Proteins
- MUC1 (Mucin 1 (MUC1))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 24-380
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This MUC1 protein is labelled with Fc Tag.
- Characteristics
- Human Mucin-1 / MUC-1 (24-380) Protein, Fc Tag (MALS verified)
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product MUC1 Protein
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- Application Notes
- MALS verified
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- MUC1 (Mucin 1 (MUC1))
- Alternative Name
- Mucin-1 (MUC1 Products)
- Synonyms
- CA 15-3 Protein, CD227 Protein, EMA Protein, H23AG Protein, KL-6 Protein, MAM6 Protein, MCKD1 Protein, MUC-1 Protein, MUC-1/SEC Protein, MUC-1/X Protein, MUC1/ZD Protein, PEM Protein, PEMT Protein, PUM Protein, Muc-1 Protein, mucin 1, cell surface associated Protein, mucin 1, transmembrane Protein, MUC1 Protein, Muc1 Protein
- Background
- Mucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
- Molecular Weight
- 60.2 kDa
- Pathways
- Negative Regulation of intrinsic apoptotic Signaling
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