Browse our Phospholamban Proteins (PLN)

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.

• phospholamban (PLN)
• phospholamban (pln)
• phospholamban (Pln)

• CMD1P protein
• CMH18 protein
• LOC100226261 protein
• Plb protein
• Plm protein

phospholamban , cardiac phospholamban , PLB