Browse our anti-AFT1 (AFT1) Antibodies

Human Activating Transcription Factor 1 (AFT1) interaction partners

1. Exome-wide association analysis identifies a rare missense variant in TCF7L2 and a common regulatory variant in ATF1 as susceptibility factors of colorectal cancer.

2. carcinogenic role of lncRNA RP11-552M11.4 in CC was mediated through miR-3941/ATF1 axis

3. Knockdown of ATF1 effectively reduced cell proliferation, induced S phase cell cycle arrest, and inhibited cell migration and invasion.

4. LncRNA GHET1 was intimately involved in the occurrence and development of HCC through regulating ATF1.

5. a breakpoint in the EWSR1-ATF1 fusion to be the same as that reported in HCCC. Established CCOC-T cells grew extremely slowly, but the cells showed highly invasive activity

6. Pin1 is a novel regulator of ATF1 at Thr184.

7. Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 gene fusion.

8. Results expand the spectrum of tumor types harboring EWSR1/FUS-ATF1 gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.

9. Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1/CREM fusions.

10. our results demonstrated that miR-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM and have potential therapeutic value.

11. genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved.

12. EWSR1-ATF1 fusion gene was found in hyalinizing clear cell carcinoma

13. Heme activates the ATF1 pathway in human macrophages via AMPK, and that a similar response occurs after treatment of cells with metformin.

14. ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression

15. Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions.

16. ATF-1 mediates HO-1 induction by heme and drives macrophage adaptation to intraplaque hemorrhage.

17. Hyalinizing clear-cell carcinoma is a unique low-grade salivary carcinoma that consistently harbors EWSR1-ATF1 fusion.

18. Differential expression of CREB/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB/ATF system.

19. An increase in phosphorylation of CREB/ATF-1 in human dental pulp cells was noted after exposure to PGF2alpha for 1-20 min,with a maximal induction at 10 min.

20. DNA cytosine methylation in the bovine leukemia virus promoter has a role in direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding

Cow (Bovine) Activating Transcription Factor 1 (AFT1) interaction partners

1. The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR of ATF1/2, and indicates a difference between short and long isoforms.

Mouse (Murine) Activating Transcription Factor 1 (AFT1) interaction partners

1. the HSF1 complex, including BRG1 and lysine acetyltransferases p300 and CREB-binding protein (CBP), is formed in a manner dependent on the phosphorylation of ATF1

2. conclude that HO-1 regulates DC maturation and function by modulating the p38 MAPK-CREB/ATF1 signaling axis

3. Dehydroepiandrosterone sulfate (DHEAS)-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor, since silencing of Gnalpha11 leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB.

4. indicate that dysregulation of p38 MAPK-CREB/ATF1 signaling axis underlies the altered function and phenotype in Nrf2-deficient DCs

5. Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.

6. miR-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.

7. ATF1 is a novel substrate of RSK2 and that RSK2-ATF1 signaling plays an important role in EGF-induced neoplastic cell transformation.

8. study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB) at the time of zygotic genome activation

9. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.

10. role in hippocampus-dependent learning

11. phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression

12. ATF1 plays a central role in adipogenesis because expression of individual master adipogenic regulators is unable to compensate for its loss. Depletion of ATF1 blocks adipogenesis in vitro and in vivo.

13. Leptin signaling in a clonal population of mouse neurotensin (NT)-expressing hypothalamic neurons, N-39, is reported.

14. PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene

15. ATF-1, via p38 MAP kinase activation, functions as a novel regulatory pathway driving UCP3 expression

Rabbit Activating Transcription Factor 1 (AFT1) interaction partners

1. Data indicate increasing expression for CREB, ATF1, and ATF3 during gastrulation.