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Exome-wide association analysis identifies a rare missense variant in TCF7L2 and a common regulatory variant in ATF1 as susceptibility factors of colorectal cancer.
carcinogenic role of lncRNA RP11-552M11.4 in CC was mediated through miR-3941/ATF1 axis
Knockdown of ATF1 effectively reduced cell proliferation, induced S phase cell cycle arrest, and inhibited cell migration and invasion.
LncRNA GHET1 was intimately involved in the occurrence and development of HCC through regulating ATF1.
a breakpoint in the EWSR1-ATF1 fusion to be the same as that reported in HCCC. Established CCOC-T cells grew extremely slowly, but the cells showed highly invasive activity
Pin1 is a novel regulator of ATF1 at Thr184.
Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 gene fusion.
Results expand the spectrum of tumor types harboring EWSR1/FUS-ATF1 gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.
Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1/CREM fusions.
our results demonstrated that miR-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM and have potential therapeutic value.
genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved.
EWSR1-ATF1 fusion gene was found in hyalinizing clear cell carcinoma
Heme activates the ATF1 pathway in human macrophages via AMPK, and that a similar response occurs after treatment of cells with metformin.
ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression
Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions.
ATF-1 mediates HO-1 induction by heme and drives macrophage adaptation to intraplaque hemorrhage.
Hyalinizing clear-cell carcinoma is a unique low-grade salivary carcinoma that consistently harbors EWSR1-ATF1 fusion.
Differential expression of CREB/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB/ATF system.
An increase in phosphorylation of CREB/ATF-1 in human dental pulp cells was noted after exposure to PGF2alpha for 1-20 min,with a maximal induction at 10 min.
DNA cytosine methylation in the bovine leukemia virus promoter has a role in direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR of ATF1/2, and indicates a difference between short and long isoforms.
the HSF1 complex, including BRG1 and lysine acetyltransferases p300 and CREB-binding protein (CBP), is formed in a manner dependent on the phosphorylation of ATF1
conclude that HO-1 regulates DC maturation and function by modulating the p38 MAPK-CREB/ATF1 signaling axis
Dehydroepiandrosterone sulfate (DHEAS)-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor, since silencing of Gnalpha11 leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB.
indicate that dysregulation of p38 MAPK-CREB/ATF1 signaling axis underlies the altered function and phenotype in Nrf2-deficient DCs
Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.
miR-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.
ATF1 is a novel substrate of RSK2 and that RSK2-ATF1 signaling plays an important role in EGF-induced neoplastic cell transformation.
study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB) at the time of zygotic genome activation
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
role in hippocampus-dependent learning
phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression
ATF1 plays a central role in adipogenesis because expression of individual master adipogenic regulators is unable to compensate for its loss. Depletion of ATF1 blocks adipogenesis in vitro and in vivo.
Leptin signaling in a clonal population of mouse neurotensin (NT)-expressing hypothalamic neurons, N-39, is reported.
PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene
ATF-1, via p38 MAP kinase activation, functions as a novel regulatory pathway driving UCP3 expression
Data indicate increasing expression for CREB, ATF1, and ATF3 during gastrulation.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
activating transcription factor 1
, cyclic AMP-dependent transcription factor ATF-1
, cAMP-dependent transcription factor ATF-1