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we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX (show ARHGEF7 Proteins) complex in health and disease
show that ARHGEF6 is constitutively linked to GIT1, a GAP of Arf family small G proteins, and that ARHGEF6 phosphorylation enables binding of the 14-3-3 adaptor protein to the ARHGEF6/GIT1 complex
The novel recycling regulator alpha-PIX and the degradation factor c-Cbl (show CBL Proteins) closely cooperate in the regulation of EGFR (show EGFR Proteins) trafficking.
c-Cbl (show CBL Proteins) negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl (show CBL Proteins) in C6 and A172 glioma cells is responsible for their malignant behavior
results suggest that low doses of chlorambucil and very low doses of chronic oxidative stress together kill Cbl (show CBL Proteins)-resistant ovarian carcinoma cells and ARHGEF6 signaling may have an instrumental role in induction of apoptosis in Cbl (show CBL Proteins)(cos) cells.
These findings suggest that alpha Pix plays an important role in mutant huntingtin (show HTT Proteins) aggregation.
The interaction of alphaPix with CagA (show S100A8 Proteins) activates PAK1 (show PAK1 Proteins), ERK (show EPHB2 Proteins) and NF-kappaB (show NFKB1 Proteins), which induces IL-8 (show IL8 Proteins) expression in H. pylori-infected gastric epithelial cells.
The plexin-B1 (show PLXNB1 Proteins)/Rac (show AKT1 Proteins) interaction inhibits PAK activation and enhances Sema4D (show SEMA4D Proteins) ligand binding
Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation.
Data suggest that Rac (show AKT1 Proteins)-dependent activation of the NFkappaB (show NFKB1 Proteins) pathway may be a critical element promoting thrombin (show F2 Proteins)-induced tissue factor (show F3 Proteins) expression and activity, and thus a prothrombotic state in pulmonary hypertension.
this study has identified a new role for Parvin (show PARVA Proteins) and alphaPix downstream of the integrin-ILK (show ILK Proteins) signaling axis for mammary epithelial cell differentiation.
Enforced expression of miR-135a in highly tumorigenic cancer stem cells strongly inhibited tumorigenesis by repressing the miR-135a direct target gene Arhgef6.
Results indicate Arhgef6 (alphaPIX) as a regulator of thymocyte migration and subsequent arrest that is linked to positive selection.
alphaPIX and GIT2 (show GIT2 Proteins) are required for neuronal differentiation.
suggest that imbalance in activity of different Rho GTPases may underlie altered neuronal connectivity and impaired synaptic function and cognition in alphaPix/Arhgef6 knockout mice
The mouse Arhgef6 gene: cDNA sequence, expression analysis, and X chromosome assignment.
ARHGEF6 is localized in dendritic spines where it contributes to regulate dendritic spine morphogenesis.
These results reveal specific roles for alphaPIX in the immune system and suggest that redundancy with betaPIX (show ARHGEF7 Proteins) precludes a more severe immune phenotype.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
PAK-interacting exchange factor alpha
, PAK-interacting exchange factor, alpha
, Rac/Cdc42 guanine exchange factor (GEF) 6
, rac/Cdc42 guanine nucleotide exchange factor 6
, rho guanine nucleotide exchange factor 6
, alpha PIX Rho GTPase guanine nucleotide exchange factor
, rac/cdc42 guanine nucleotide exchange factor 6