FGD4 Proteins

Protein Summary

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.

Alternative names and synonyms associated with FGD4

• FYVE, RhoGEF and PH domain containing 4 (FGD4) antibody
• FYVE, RhoGEF and PH domain containing 4 (Fgd4) antibody

• 9030023J02Rik antibody
• 9330209B17Rik antibody
• CMT4H antibody
• Frabp antibody
• ZFYVE6 antibody

Protein level used designations for FGD4

FGD1 family, member 4 , FGD1-related F-actin-binding protein , FYVE, RhoGEF and PH domain-containing protein 4 , actin-filament binding protein frabin , zinc finger FYVE domain-containing protein 6 , Fgd1-related F-actin-binding protein , actin filament-binding protein frabin , frabin