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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN803887
Rush, Abel, Valadez, Pearson, Cooper: Activation of the Hedgehog pathway in pilocytic astrocytomas. in Neuro-oncology 2010
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Human EGF Protein expressed in Human - ABIN2452189
Cohen, Carpenter: Human epidermal growth factor: isolation and chemical and biological properties. in Proceedings of the National Academy of Sciences of the United States of America 1975
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN2452188
Carpenter, Cohen: Epidermal growth factor. in The Journal of biological chemistry 1990
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN593405
An, Gip, Kim, Wu, Park, McVaugh, Schaffer, Bertozzi, Lebrilla: Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells. in Molecular & cellular proteomics : MCP 2012
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN987821
Katagiri, Takahashi: Potential relationship between normalization of endometrial epidermal growth factor profile and restoration of fertility in repeat breeder cows. in Animal reproduction science 2006
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN2215428
Zhou, Zhang, Jin, Chen, Wu, Li, Yue, Luo, Wang: Prokaryotic expression and refolding of EGFR extracellular domain and generation of phage display human scFv against EGFR. in Biomedicine & pharmacotherapy 2013
Zebrafish scube1 (show SCUBE1 Proteins) (signal peptide-CUB (complement protein C1r (show C1R Proteins)/C1s (show C1S Proteins), Uegf, and Bmp1 (show BMP1 Proteins))-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis
EGF is likely a potential paracrine/juxtacrine factor from the oocytes to regulate the function of the follicle cells.
These results suggest that there is an EGF signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.
EGF and TNFalpha (show TNF Proteins) cooperatively promoted the motility of HCC (show FAM126A Proteins) cells mainly through NF-kappaB (show NFKB1 Proteins)/p65 (show GORASP1 Proteins) mediated synergistic induction of FN in vitro. These findings highlight the crosstalk between EGF and TNFalpha (show TNF Proteins) in promoting HCC (show FAM126A Proteins), and provide potential targets for HCC (show FAM126A Proteins) prevention and treatment.
Data suggest that EGF induces colorectal cancer cells to undergo epithelial-mesenchymal transition, enhances their ability to invade/migrate, and promotes phosphorylation of Ezrin (show EZR Proteins) at Tyr353. (EGF = epidermal growth factor)
Simulation results indicate that human epidermal growth factor receptor (show EGFR Proteins) (hEGFR) soluble soluble extracellular domains (sECD):EGF show different dynamic properties between the two pHs (show PCBD1 Proteins), and the complex may have a higher tendency of activation at pH 8.5.
EGF and IP-10 (show CXCL10 Proteins) were significantly elevated and GRO (show CXCL1 Proteins) levels were lower in the tear profile of HIV patients with dry eye disease (DED (show AATF Proteins)) compared to immunocompetent patients with DED (show AATF Proteins).
Data (including data from studies using transgenic/knockout mice) suggest that surfactant protein A1 (SPA1) interferes with EGF binding to EGFR (show EGFR Proteins) in pulmonary alveoli cell lines; SPA1 (show SIPA1 Proteins) directly binds extracellular domain of EGFR (show EGFR Proteins); binding of SPA1 (show SIPA1 Proteins) to EGFR (show EGFR Proteins) appears to be different from binding of SPD (show HOXD13 Proteins) to EGFR (show EGFR Proteins); binding of SPA1 (show SIPA1 Proteins) to EGFR (show EGFR Proteins) does not suppress EGF-induced phosphorylation of EGFR (show EGFR Proteins) or cell proliferation.
EGF-AREG (show AREG Proteins) interplay in airway basal cell stem/progenitor cells is one of the mechanisms that mediates the interconnected pathogenesis of all major smoking-induced lesions in the human airway epithelium.
caspase-3 (show CASP3 Proteins) inhibitors also suppressed the attenuation of cell adhesion and phosphorylation of p38 MAPK (show MAPK14 Proteins) by EGF-F9. Our data indicated that EGF-F9 activated signals for apoptosis and induced de-adhesion in a caspase-3 (show CASP3 Proteins) dependent manner.
evidence that CDK1 (show CDK1 Proteins)/2 participate in the regulation of constitutive pre-mRNA splicing by EGF stimulation in MDA-MB-468 cells.
The EGF rs4444903 GG genotype is associated with higher susceptibility to HCV-related liver cirrhosis and hepatocellular carcinoma in the Chinese Han population
TGF-beta (show TGFB1 Proteins) opposes EGF-mediated sensitization to TRAIL-induced caspase-8 (show CASP8 Proteins) activation and apoptosis in non-transformed breast epithelial cells. EGF and TGF-beta (show TGFB1 Proteins) finely regulate sensitivity of human breast epithelial cells to TRAIL which may be relevant during morphogenesis.
hijacks miR (show MLXIP Proteins)-198/FSTL1 (show FSTL1 Proteins) wound-healing switch and steers a two-pronged pathway toward metastasis
These results indicate that Kindlin-1 (show FERMT1 Proteins) is essential in EGF-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF in the treatment of acute wounds.
concentration of EGF is critical for the switch between hair follicle growth and inhibition, and EGF promotes DP cell proliferation via Notch (show NOTCH1 Proteins) signaling pathway
EGF promotes FoxM1 (show FOXM1 Proteins) expression through the ERK (show EPHB2 Proteins) signal pathway
Data indicate that Sonic hedgehog (Shh (show SHH Proteins)) stimulate branching morphogenesis (BrM (show SMARCA2 Proteins)) and induced synthesis of mRNAs for Ptch1 (show PTCH1 Proteins) protein, epidermal growth factor (EGF) and receptors of the ErbB (show EGFR Proteins) receptors ErbB1 (show EGFR Proteins), ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins).
Either LIF (show LIF Proteins) or EGF is needed during development of pre-implantation embryo.
PXR (show NR1I2 Proteins) activation stimulates EGF-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (show FOXO3 Proteins) from accelerating cell-cycle progression.
Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr (show EGFR Proteins) signaling.
modulation of EGF signaling affects in vitro expansion and differentiation of progenitors from embryonic pancreas of both mice and man.
TLR4 (show TLR4 Proteins) blockade prevented TPN (show TAPBP Proteins)-associated intestinal mucosa atrophy by preserving proliferation and preventing apoptosis. This is driven by a reduction in TNF-alpha (show TNF Proteins) abundance and increased EGF.
Interval between litters and litter size may be linked with EGF polymorphisms in pigs.
10 nM/L EGF was the optimal dose for serum-free culture, which can replace traditional standard serum medium for in vitro expansion of miniature pig bone marrow-derived mesenchymal stem cells.
EGF coordinately activates multiple cell signaling pathways critical to proliferation, migration and survival of trophectoderm cells.
progesterone-induced TACE/ADAM17 (show ADAM17 Proteins) leads to production of soluble EGF domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
The phase-related expression of EGF and EGFR (show EGFR Proteins) in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF and its receptor on the uterine artery and the region supplying these vessels.
EGF appears to sensitize epithelial cells to the detrimental effects of IFN-alpha (show IFNA Proteins) but also helps to restore barrier function in the healing phase.
analysis of EGF in dairy cows reveals increased EGF concentrations for 2-3 days between Days 2 and 5
Data suggest that EGF expression in endometrium varies by species and parity; in Japanese Black cows, EGF expression is consistently high, while in Holstein cows, EGF expression is down-regulated in postpartum period after second calving.
Data suggest that epidermal growth factor receptor (show EGFR Proteins) B [ErbB (show EGFR Proteins)] isoforms and their ligands (epidermal growth factor [EGF], amphiregulin (show AREG Proteins) [AREG (show AREG Proteins)], and neuregulin-1 (show NRG1 Proteins) [NRG1 (show NRG1 Proteins)]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
EGF plays a role during bovine placentation.
Data suggest that epidermal growth factor (EGF) and EGF receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
epidermal growth factor (beta-urogastrone)
, pro-epidermal growth factor
, Pro-epidermal growth factor precursor (EGF)